Výsledky vyhledávání - "G-Quadruplexe"

Akademický článek

Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction

Autor: Shalu Sharma, Ananda Kishore Mukherjee, Shuvra Shekhar Roy, Sulochana Bagri, Silje Lier, Meenakshi Verma, Antara Sengupta, Manish Kumar, Gaute Nesse, Deo Prakash Pandey, Shantanu Chowdhury

Publikováno v: Cell Reports, Vol 35, Iss 7, Pp 109154- (2021)

Summary: Human telomerase reverse transcriptase (hTERT) remains suppressed in most normal somatic cells. Resulting erosion of telomeres leads eventually to replicative senescence. Reactivation of hTERT maintains telomeres and triggers progression of

Externí odkaz: https://doaj.org/article/31ab0e244fa34537a9b0a97737a04c10

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Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells

Autor: Simona Marzano, Giulia Miglietta, Rita Morigi, Jessica Marinello, Andrea Arleo, Monica Procacci, Alessandra Locatelli, Alberto Leoni, Bruno Pagano, Antonio Randazzo, Jussara Amato, Giovanni Capranico

Publikováno v: Journal of medicinal chemistry. 65(18)

G-quadruplex (G4) ligands are investigated to discover new anticancer drugs with increased cell-killing potency. These ligands can induce genome instability and activate innate immune genes at non-cytotoxic doses, opening the discovery of cytostatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57517eddcf3cab2b2e5aea3f8919d47
https://pubmed.ncbi.nlm.nih.gov/36074772

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G-quadruplex binders as cytostatic modulators of innate immune genes in cancer cells

Autor: Marco Russo, Giovanni Capranico, Giulia Miglietta, Renée C. Duardo

Publikováno v: Nucleic Acids Research

G-quadruplexes (G4s) are non-canonical nucleic acid structures involved in fundamental biological processes. As G4s are promising anticancer targets, in past decades the search for effective anticancer G4 binders aimed at the discovery of more cytoto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b20edeb20e0351eeb8d735154aa2ed
http://europepmc.org/articles/PMC8266585

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Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells

Autor: Jussara Amato, Giulia Miglietta, Nunzia Iaccarino, Antonio Randazzo, Giovanni Capranico, Bruno Pagano, Alessandra Locatelli, Ettore Novellino, Alberto Leoni, Rita Morigi

Publikováno v: Journal of Medicinal Chemistry

Targeting G-quadruplex structures is currently viewed as a promising anticancer strategy. Searching for potent and selective G-quadruplex binders, here we describe a small series of new monohydrazone derivatives designed as analogues of a lead which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c6b1ff6066c49300b5f3c2abce43c7
http://europepmc.org/articles/PMC7997572

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Ligands stimulating antitumour immunity as the next G-quadruplex challenge

Autor: Giulia Miglietta, Jessica Marinello, Marco Russo, Giovanni Capranico

G-quadruplex (G4) binders have been investigated to discover new anticancer drugs worldwide in past decades. As these ligands are generally not highly cytotoxic, the discovery rational was mainly based on increasing the cell-killing potency. Neverthe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab47719cd2e5f77ddd4dcaafaa2e8c4
https://hdl.handle.net/11585/897431

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Targeting of Telomeric Repeat-Containing RNA G-Quadruplexes: From Screening to Biophysical and Biological Characterization of a New Hit Compound

Autor: Bruno Pagano, Erica Salvati, Simona Marzano, Stefano De Tito, Eleonora Vertecchi, Jussara Amato, Anna Di Porzio, Nunzia Iaccarino, Antonio Randazzo

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 10315, p 10315 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 19

DNA G-quadruplex (G4) structures, either within gene promoter sequences or at telomeres, have been extensively investigated as potential small-molecule therapeutic targets. However, although G4s forming at the telomeric DNA have been extensively inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f20cfa33c2d6415fc14d7a244f853ab
https://www.mdpi.com/1422-0067/22/19/10315

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DNA Binding Mode Analysis of a Core-Extended Naphthalene Diimide as a Conformation-Sensitive Fluorescent Probe of G-Quadruplex Structures

Autor: Rosa Gaglione, Ettore Napolitano, Chiara Platella, Valentina Pirota, Daniela Montesarchio, Filippo Doria, Angela Arciello, Domenica Musumeci

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 10624, p 10624 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 19

G-quadruplex existence was proved in cells by using both antibodies and small molecule fluorescent probes. However, the G-quadruplex probes designed thus far are structure- but not conformation-specific. Recently, a core-extended naphthalene diimide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1601cdac926c38b7b5fb9ff168bcaa
https://www.mdpi.com/1422-0067/22/19/10624

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Unraveling the binding characteristics of small ligands to telomeric DNA by pressure modulation

Autor: Oliva, Rosario, Mukherjee, Sanjib, Winter, Roland

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Recently, non-canonical DNA structures, such as G-quadruplexes (GQs), were found to be highly pressure sensitive, suggesting that pressure modulation studies can provide additional mechanistic details of such biomolecular systems. Using FRET and CD s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8418fe187c0a0164c5f36e54c62dc43d
http://hdl.handle.net/2003/40590

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Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction

Autor: Shantanu Chowdhury, Antara Sengupta, Silje Lier, Meenakshi Verma, Manish Kumar, Shalu Sharma, Deo Prakash Pandey, Shuvra Shekhar Roy, Ananda Kishore Mukherjee, Gaute Nesse, Sulochana Bagri

Publikováno v: Cell Reports, Vol 35, Iss 7, Pp 109154-(2021)
Cell reports

Summary Human telomerase reverse transcriptase (hTERT) remains suppressed in most normal somatic cells. Resulting erosion of telomeres leads eventually to replicative senescence. Reactivation of hTERT maintains telomeres and triggers progression of >

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d23cda219d3c70d2affd098fe25324d
http://www.sciencedirect.com/science/article/pii/S2211124721004964

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The Binding Pocket at the Interface of Multimeric Telomere G-quadruplexes: Myth or Reality?

Autor: Barbara Zambelli, Ilse Manet, Mauro Freccero, Giorgio Colombo, Filippo Doria, Francesco Manoli

Publikováno v: Chemistry (Weinh., Print) 27 (2021): 11707–11720. doi:10.1002/chem.202101486
info:cnr-pdr/source/autori:Manoli, Francesco; Doria, Filippo; Colombo, Giorgio; Zambelli, Barbara; Freccero, Mauro; Manet, Ilse/titolo:The Binding Pocket at the Interface of Multimeric Telomere G-quadruplexes: Myth or Reality?/doi:10.1002%2Fchem.202101486/rivista:Chemistry (Weinh., Print)/anno:2021/pagina_da:11707/pagina_a:11720/intervallo_pagine:11707–11720/volume:27
Chemistry (Weinheim an Der Bergstrasse, Germany)

Human telomeric DNA with hundreds of repeats of the 5’‐TTAGGG‐3’ motif plays a crucial role in several biological processes. It folds into G‐quadruplex (G4) structures and features a pocket at the interface of two contiguous G4 blocks. Up t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aada1de084a0a534794f597c8803fd5
https://hdl.handle.net/11585/856814

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