Zobrazeno 1 - 10
of 18 278
pro vyhledávání: '"G quadruplex"'
Autor:
Sean M. Flynn, Somdutta Dhir, Krzysztof Herka, Colm Doyle, Larry Melidis, Angela Simeone, Winnie W. I. Hui, Rafael de Cesaris Araujo Tavares, Stefan Schoenfelder, David Tannahill, Shankar Balasubramanian
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Methods to measure chromatin contacts at genomic regions bound by histone modifications or proteins are important tools to investigate chromatin organization. However, such methods do not capture the possible involvement of other epigenomic
Externí odkaz:
https://doaj.org/article/64f8f18f52c349d5bcf820beb8d79a27
G-Quadruplex DNA as a Macromolecular Target for Semi-Synthetic Isoflavones Bearing B-Ring Tosylation
Autor:
Giovanni Ribaudo, Margrate Anyanwu, Matteo Giannangeli, Erika Oselladore, Alberto Ongaro, Maurizio Memo, Alessandra Gianoncelli
Publikováno v:
Macromol, Vol 4, Iss 3, Pp 556-565 (2024)
Guanine-rich sequences of nucleic acids, including DNA and RNA, are known to fold into non-canonical structures named G-quadruplexes (G4s). Such arrangements of these macromolecular polymers are mainly located in telomeres and in promoter regions of
Externí odkaz:
https://doaj.org/article/9978c15c232b49ee99f7b2753313e241
Autor:
Angelika Lahnsteiner, Victoria Ellmer, Anna Oberlercher, Zita Liutkeviciute, Esther Schönauer, Bernhard Paulweber, Elmar Aigner, Angela Risch
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract The alarming increase in global rates of metabolic diseases (MetDs) and their association with cancer risk renders them a considerable burden on our society. The interplay of environmental and genetic factors in causing MetDs may be reflecte
Externí odkaz:
https://doaj.org/article/3a56db45a22140abb3d85f95931238fc
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-23 (2024)
Abstract Background Cis-regulatory elements (CREs) are crucial for regulating gene expression, and G-quadruplexes (G4s), as prototypal non-canonical DNA structures, may play a role in this regulation. However, the relationship between G4s and CREs, e
Externí odkaz:
https://doaj.org/article/4696065c6eba4fd4af429a9c6c31cad6
Publikováno v:
Advanced Sensor and Energy Materials, Vol 3, Iss 3, Pp 100112- (2024)
G-quadruplex is a high-level structure composed of folded DNA or RNA rich in tandem repeats of guanine (G). In recent years, G-quadruplex is widely used in various fields due to its unique structural properties. This article briefly introduces the st
Externí odkaz:
https://doaj.org/article/55d9ba9af5814d5f8189ef2331ba0cde
Autor:
Savani Anbalagan
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 1-6 (2024)
Understanding how cells sense gases or gaseous solutes is a fundamental question in biology and is pivotal for the evolution of molecular and organismal life. In numerous organisms, gases can diffuse into cells, be transported, generated, and sensed.
Externí odkaz:
https://doaj.org/article/8f6e101981934c3d8f1254e4e6343764
Publikováno v:
Engineering, Vol 38, Iss , Pp 39-51 (2024)
DNA guanine (G)-quadruplexes (G4s) are unique secondary structures formed by two or more stacked G-tetrads in G-rich DNA sequences. These structures have been found to play a crucial role in highly transcribed genes, especially in cancer-related onco
Externí odkaz:
https://doaj.org/article/758e276aab4243aba79bfbbf79874b32
Autor:
Lili Hegedus, Agnes Toth, Gabor M. Harami, Janos Palinkas, Nargis Karatayeva, Eniko Sajben-Nagy, Szabolcs Bene, Sara Afzali Jaktajdinani, Mihaly Kovacs, Szilvia Juhasz, Peter Burkovics
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Genome replication is frequently impeded by highly stable DNA secondary structures, including G-quadruplex (G4) DNA, that can hinder the progression of the replication fork. Human WRNIP1 (Werner helicase Interacting Protein 1) associates wit
Externí odkaz:
https://doaj.org/article/ef8693911000466fb2cdcfe50eeb72f6
Autor:
Jingxia Han, Rong Qin, Shaoting Zheng, Xiaohui Hou, Xiaorui Wang, Huihui An, Zhongwei Li, Yinan Li, Heng Zhang, Denghui Zhai, Huijuan Liu, Jing Meng, Tao Sun
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Myeloid-derived suppressor cells (MDSCs) promote tumor growth, metastasis, and lead to immunotherapy resistance. Studies revealed that miRNAs are also expressed in MDSCs and promote the immunosuppressive function of MDSCs. Current
Externí odkaz:
https://doaj.org/article/2cbccae9ff444b59b515604832d9fd6f
Publikováno v:
eLife, Vol 13 (2024)
The interplay between G4s and R-loops are emerging in regulating DNA repair, replication, and transcription. A comprehensive picture of native co-localized G4s and R-loops in living cells is currently lacking. Here, we describe the development of Hep
Externí odkaz:
https://doaj.org/article/a2971be1a14e4f40a988d217659e5d56