Zobrazeno 1 - 10
of 1 906
pro vyhledávání: '"G protein-coupled bile acid receptor"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 5, Pp 1939-1950 (2024)
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been significantly alleviated. However, long-term health effects and prevention strategy remain unresolved. Thus, it is esse
Externí odkaz:
https://doaj.org/article/eb88fe8b810d4778b68c31a4ea0c1331
Akademický článek
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Autor:
Michele Biagioli, Stefano Fiorucci
Publikováno v:
Liver Research, Vol 5, Iss 3, Pp 119-141 (2021)
Bile acids are a family of atypical steroids generated at the interface of liver-intestinal microbiota acting on a ubiquitously expressed family of membrane and nuclear receptors known as bile acid activated receptors. The two best characterized rece
Externí odkaz:
https://doaj.org/article/f76e75226dbe44efbf673b63060db1d7
Autor:
Stefano Fiorucci, Pasquale Rapacciuolo, Bianca Fiorillo, Rosalinda Roselli, Silvia Marchianò, Cristina Di Giorgio, Martina Bordoni, Rachele Bellini, Chiara Cassiano, Paolo Conflitti, Bruno Catalanotti, Vittorio Limongelli, Valentina Sepe, Michele Biagioli, Angela Zampella
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are two highly prevalent human diseases caused by excessive fat deposition in the liver. Although multiple approaches have been suggested, NAFLD/NASH remains an unmet cl
Externí odkaz:
https://doaj.org/article/a6792e07fe39402882b5e47cfb1a7855
Akademický článek
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Autor:
Alzbeta Stefela, Miroslav Kaspar, Martin Drastik, Thales Kronenberger, Stanislav Micuda, Martin Dracinsky, Blanka Klepetarova, Eva Kudova, Petr Pavek
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Bile acids (BAs) are key signaling steroidal molecules that regulate glucose, lipid, and energy homeostasis via interactions with the farnesoid X receptor (FXR) and G-protein bile acid receptor 1 (GPBAR1). Extensive medicinal chemistry modifications
Externí odkaz:
https://doaj.org/article/41d6b0e2df9d4724951d8ee7df1dc6a6
Autor:
Guoxiang Xie, Runqiu Jiang, Xiaoning Wang, Ping Liu, Aihua Zhao, Yiran Wu, Fengjie Huang, Zhipeng Liu, Cynthia Rajani, Xiaojiao Zheng, Jiannan Qiu, Xiaoling Zhang, Suwen Zhao, Hua Bian, Xin Gao, Beicheng Sun, Wei Jia
Publikováno v:
EBioMedicine, Vol 66, Iss , Pp 103290- (2021)
Background: Significantly elevated serum and hepatic bile acid (BA) concentrations have been known to occur in patients with liver fibrosis. However, the roles of different BA species in liver fibrogenesis are not fully understood. Methods: We quanti
Externí odkaz:
https://doaj.org/article/e21836924d3c40c8ab2ea6fa1f491147
Publikováno v:
Di-san junyi daxue xuebao, Vol 41, Iss 10, Pp 939-946 (2019)
Objective To investigate the inhibitory effect of G protein-coupled bile acid receptor 1 (TGR5) on endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy and explore the mechanism. Methods Primary cultured neonatal rat cardiomyocytes were exposed to E
Externí odkaz:
https://doaj.org/article/4b8508c4627c4c94a7df68c071c12eec
Autor:
Hyeonhui Kim, Sungsoon Fang
Publikováno v:
Laboratory Animal Research, Vol 34, Iss 4, Pp 140-146 (2018)
Abstract Though bile acids have been well known as digestive juice, recent studies have demonstrated that bile acids bind to their endogenous receptors, including Farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (GPBAR1; TGR5) an
Externí odkaz:
https://doaj.org/article/a1dfde13afe445dabf4282183ab9f575