Zobrazeno 1 - 10
of 687
pro vyhledávání: '"G protein coupled receptors (GPCRs)"'
Autor:
Liangjing Lv, Yong Liu, Jiachuan Xiong, Shaobo Wang, Yan Li, Bo Zhang, Yinghui Huang, Jinghong Zhao
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Acute kidney injury (AKI) is a clinical condition characterized by a rapid decline in kidney function, which is associated with local inflammation and programmed cell death in the kidney. The G protein-coupled receptors (GPCRs) represent the
Externí odkaz:
https://doaj.org/article/97ada73864354f809fdd524c0254de87
Autor:
Anna Drzazga, Przemysław Bernat, Adriana Nowak, Marcin Szustak, Eliza Korkus, Edyta Gendaszewska-Darmach, Maria Koziołkiewicz
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117467- (2024)
Commensal microbiota is crucial for nutrient digestion and production of biologically active molecules, many of which mimic endogenous ligands of human GPCRs. Bacteroides spp. are among the most abundant bacteria residing in the human gut and their a
Externí odkaz:
https://doaj.org/article/cd8261fdd29d419e8f1ad518f1557b93
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10618 (2024)
Insecticide resistance in insects, driven by the overexpression of P450 enzymes, presents a significant challenge due to the enhanced metabolic detoxification of insecticides. Although the transcriptional regulation of P450 genes is not yet fully und
Externí odkaz:
https://doaj.org/article/e7ffac15df904ea6bedcb30edfbcfc37
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 172, Iss , Pp 116245- (2024)
‘Globesity’ is a foremost challenge to the healthcare system. The limited efficacy and adverse effects of available oral pharmacotherapies pose a significant obstacle in the fight against obesity. The biology of the leading incretin hormone gluca
Externí odkaz:
https://doaj.org/article/6874e76769684b69833793033db890ff
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8083 (2024)
Cancer cells depend on specific oncogenic pathways or present a genetic alteration that leads to a particular disturbance. Still, personalized and targeted biological therapy remains challenging, with current efforts generally yielding disappointing
Externí odkaz:
https://doaj.org/article/41a198f733d84bc1bc6958313d0455d3
Autor:
Jane B. Ramaswe, Emma T. Steenkamp, Lieschen De Vos, Felix F. Fru, Omotayo O. Adegeye, Brenda D. Wingfield
Publikováno v:
Pathogens, Vol 13, Iss 5, p 425 (2024)
In ascomycetous fungi, sexual mate recognition requires interaction of the Ste2 receptor protein produced by one partner with the α-factor peptide pheromone produced by the other partner. In some fungi, Ste2 is further needed for chemotropism toward
Externí odkaz:
https://doaj.org/article/e0a48098118c4243bd16cad4a674278d
Publikováno v:
Mathematical Biosciences and Engineering, Vol 20, Iss 2, Pp 2588-2608 (2023)
G protein-coupled receptors (GPCRs) have been the targets for more than 40% of the currently approved drugs. Although neural networks can effectively improve the accuracy of prediction with the biological activity, the result is undesirable in the li
Externí odkaz:
https://doaj.org/article/95e58248a911471690b068d51859f0fe
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
The largest family of transmembrane receptors are G-protein-coupled receptors (GPCRs). These receptors respond to perceived environmental signals and infect their host plants. Family A of the GPCR includes opsin. However, there is little known about
Externí odkaz:
https://doaj.org/article/1dcef8c67af1400abbba4f6a9d220dff
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Numerous studies have highlighted the crucial role of G protein-coupled receptors (GPCRs) in tumor microenvironment (TME) remodeling and their correlation with tumor progression. However, the association between GPCRs and the TME in gliob
Externí odkaz:
https://doaj.org/article/89feac6eadee4b64b05942f1f041b857
Autor:
Jeetendra Kumar Nag, Sorina Grisaru-Granovsky, Shunit Armon, Tatyana Rudina, Priyanga Appasamy, Rachel Bar-Shavit
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 246 (2024)
Studying primordial events in cancer is pivotal for identifying predictive molecular indicators and for targeted intervention. While the involvement of G-protein-coupled receptors (GPCRs) in cancer is growing, GPCR-based therapies are yet rare. Here,
Externí odkaz:
https://doaj.org/article/24158ce71a4e4b71883c28206189c095