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Activity of high-dose epirubicin combined with gemcitabine in advanced non-small-cell lung cancer: a multicenter phase I and II study

Autor: D.Th. Sleijfer, J B E Smeets, Hendricus Groen, G de Leede, Z Erjavec, J Nabers, J. W. G. van Putten, P Eppinga

Publikováno v: British Jounal of Cancer, 82(4), 806-811. Nature Publishing Group
British Journal of Cancer

The aim of the study was to evaluate efficacy and tolerance of epirubicin and gemcitabine as first-line chemotherapy in patients with advanced non-small-cell lung cancer. A phase I study was performed with the combination of escalating doses of epiru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad73d538dfb2e33efd1e910d360efb84
https://doi.org/10.1054/bjoc.1999.1003

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Site specific rectal drug administration in man with an osmotic system: influence on 'first-pass' elimination of lidocaine

Autor: L G, de Leede, A G, de Boer, C D, Feijen, D D, Breimer

Publikováno v: Pharmaceutical research. 1(3)

Lidocaine was administered to healthy volunteers at different sites in the rectum. Unchanged drug and monoethylglycinexylidide (MEGX) concentrations were measured in plasma with a newly developed gas chromatographic method. Lidocaine was given rectal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a91fea25f6d58b969b096a5dd953eedf
https://pubmed.ncbi.nlm.nih.gov/24277250

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Avoidance of 'first-pass' elimination of rectally administered propranolol in relation to the site of absorption in rats

Autor: L G, de Leede, A G, de Boer, J P, Havermans, D D, Breimer

Publikováno v: Pharmaceutical research. 1(4)

The extent of "first-pass" elimination of racemic propranolol and dextropropranolol in doses of 0.25 or 0.50 mg was investigated in relation to the site of drug administration in the rectum of rats. The compounds were given orally, i.v., and rectally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5b8d1db714dfdb0ec94d86fe52d5b56b
https://pubmed.ncbi.nlm.nih.gov/24277285

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First-line gemcitabine with cisplatin or epirubicin in advanced non-small-cell lung cancer: a phase III trial

Autor: Hendrika Boezen, Hendricus Groen, J. W. G. van Putten, Z. Erjavec, P. Eppinga, Floris M Wachters, E.G.E. de Vries, G de Leede, Henk Kramer, J H Strijbos

Publikováno v: British Jounal of Cancer, 89(7), 1192-1199. Nature Publishing Group
British Journal of Cancer

The purpose of our study was to compare progression-free survival and quality of life (QOL) after cisplatin-gemcitabine (CG) or epirubicin-gemcitabine (EG) in chemotherapy-naive patients with unresectable non-small-cell lung cancer. Patients (n = 240

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9dfcf9bb8ca6db622c85a7b5470b6c
https://research.rug.nl/en/publications/081c8799-c354-4d65-b0be-d1dda1552665

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Correlation between antipyrine metabolite formation and theophylline metabolism in humans after simultaneous single-dose administration and at steady state

Autor: M W, Teunissen, L G, De Leede, J K, Boeijinga, D D, Breimer

Publikováno v: The Journal of pharmacology and experimental therapeutics. 233(3)

To nine healthy male volunteers two model substrates for oxidative drug-metabolizing enzyme activity, viz, antipyrine (A) and theophylline (T) were administered simultaneously by the p.o. route. To six of them, the same two drugs were also administer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26ce58a55565c8c32de5997710ee263d
https://pubmed.ncbi.nlm.nih.gov/4009489

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Avoidance of 'first-pass' elimination of rectally administered lidocaine in relation to the site of absorption in rats

Autor: L G, de Leede, A G, de Boer, C P, Roozen, D D, Breimer

Publikováno v: The Journal of pharmacology and experimental therapeutics. 225(1)

The extent of "first-pass" elimination of lidocaine in relation to the site of absorption in the rectum of rats was investigated. Male Wistar rats received lidocaine orally, i.v. or rectally at 4, 2, 1 and at about 0.2 cm from the anus. In all cases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b01e9359d6513ddc162cdf8f77d696af
https://pubmed.ncbi.nlm.nih.gov/6834271

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