Zobrazeno 1 - 10
of 712
pro vyhledávání: '"G Woodruff"'
Autor:
Natasha Spottiswoode, Alexandra Tsitsiklis, Victoria T. Chu, Hoang Van Phan, Catherine DeVoe, Christina Love, Rajani Ghale, Joshua Bloomstein, Beth Shoshana Zha, Cole P. Maguire, Abigail Glascock, Aartik Sarma, Peter M. Mourani, Katrina L. Kalantar, Angela Detweiler, Norma Neff, Sidney C. Haller, COMET Consortium, Joseph L. DeRisi, David J. Erle, Carolyn M. Hendrickson, Kirsten N. Kangelaris, Matthew F. Krummel, Michael A. Matthay, Prescott G. Woodruff, Carolyn S. Calfee, Charles R. Langelier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Secondary bacterial pneumonia (2°BP) is associated with significant morbidity following respiratory viral infection, yet remains incompletely understood. In a prospective cohort of 112 critically ill adults intubated for COVID-19, we compar
Externí odkaz:
https://doaj.org/article/c54e44e92cce4848a4f22b7f58a64b95
Autor:
Lucile P. A. Neyton, Ravi K. Patel, Aartik Sarma, UCSF COMET Consortium, Andrew Willmore, Sidney C. Haller, Kirsten N. Kangelaris, Walter L. Eckalbar, David J. Erle, Matthew F. Krummel, Carolyn M. Hendrickson, Prescott G. Woodruff, Charles R. Langelier, Carolyn S. Calfee, Gabriela K. Fragiadakis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Dexamethasone is the standard of care for critically ill patients with COVID-19, but the mechanisms by which it decreases mortality and its immunological effects in this setting are not understood. Here we perform bulk and single-cell RNA se
Externí odkaz:
https://doaj.org/article/a07e6d9546564fe3af6acbe7a47ce91d
Autor:
Jamie L. Everman, Satria P. Sajuthi, Maude A. Liegeois, Nathan D. Jackson, Erik H. Collet, Michael C. Peters, Maurizio Chioccioli, Camille M. Moore, Bhavika B. Patel, Nathan Dyjack, Roger Powell, Cydney Rios, Michael T. Montgomery, Celeste Eng, Jennifer R. Elhawary, Angel C. Y. Mak, Donglei Hu, Scott Huntsman, Sandra Salazar, Luigi Feriani, Ana Fairbanks-Mahnke, Gianna L. Zinnen, Cole R. Michel, Joe Gomez, Xing Zhang, Vivian Medina, Hong Wei Chu, Pietro Cicuta, Erin D. Gordon, Pamela Zeitlin, Victor E. Ortega, Nichole Reisdorph, Eleanor M. Dunican, Monica Tang, Brett M. Elicker, Travis S. Henry, Eugene R. Bleecker, Mario Castro, Serpil C. Erzurum, Elliot Israel, Bruce D. Levy, David T. Mauger, Deborah A. Meyers, Kaharu Sumino, David S. Gierada, Annette T. Hastie, Wendy C. Moore, Loren C. Denlinger, Nizar N. Jarjour, Mark L. Schiebler, Sally E. Wenzel, Prescott G. Woodruff, Jose Rodriguez-Santana, Chad G. Pearson, Esteban G. Burchard, John V. Fahy, Max A. Seibold
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract By incompletely understood mechanisms, type 2 (T2) inflammation present in the airways of severe asthmatics drives the formation of pathologic mucus which leads to airway mucus plugging. Here we investigate the molecular role and clinical si
Externí odkaz:
https://doaj.org/article/e5fbd453726447a6a3e42371a05beeb5
Autor:
Katarina M. DiLillo, Katy C. Norman, Christine M. Freeman, Stephanie A. Christenson, Neil E. Alexis, Wayne H. Anderson, Igor Z. Barjaktarevic, R. Graham Barr, Alejandro P. Comellas, Eugene R. Bleecker, Richard C. Boucher, David J. Couper, Gerard J. Criner, Claire M. Doerschuk, J. Michael Wells, MeiLan K. Han, Eric A. Hoffman, Nadia N. Hansel, Annette T. Hastie, Robert J. Kaner, Jerry A. Krishnan, Wassim W. Labaki, Fernando J. Martinez, Deborah A. Meyers, Wanda K. O’Neal, Victor E. Ortega, Robert Paine, Stephen P. Peters, Prescott G. Woodruff, Christopher B. Cooper, Russell P. Bowler, Jeffrey L. Curtis, Kelly B. Arnold, SPIROMICS investigators
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Accelerated progression of chronic obstructive pulmonary disease (COPD) is associated with increased risks of hospitalization and death. Prognostic insights into mechanisms and markers of progression could facilitate development of disease-m
Externí odkaz:
https://doaj.org/article/44f990fcab4543089c5321fad16440df
Autor:
Kristina Johansson, John D. Gagnon, Simon K. Zhou, Marlys S. Fassett, Andrew W. Schroeder, Robin Kageyama, Rodriel A. Bautista, Hewlett Pham, Prescott G. Woodruff, K. Mark Ansel
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113298- (2023)
Summary: The miR-15/16 family targets a large network of genes in T cells to restrict their cell cycle, memory formation, and survival. Upon T cell activation, miR-15/16 are downregulated, allowing rapid expansion of differentiated effector T cells t
Externí odkaz:
https://doaj.org/article/769f6088e5054e208c6c0b1f112161c5
Autor:
Jason A. Hackney, Haridha Shivram, Jason Vander Heiden, Chris Overall, Luz Orozco, Xia Gao, Eugene Kim, Nathan West, Aditi Qamra, Diana Chang, Arindam Chakrabarti, David F. Choy, Alexis J. Combes, Tristan Courau, Gabriela K. Fragiadakis, Arjun Arkal Rao, Arja Ray, Jessica Tsui, Kenneth Hu, Nicholas F. Kuhn, Matthew F. Krummel, David J. Erle, Kirsten Kangelaris, Aartik Sarma, Zoe Lyon, Carolyn S. Calfee, Prescott G. Woodruff, Rajani Ghale, Eran Mick, Ashley Byrne, Beth Shoshana Zha, Charles Langelier, Carolyn M. Hendrickson, Monique G.P. van der Wijst, George C. Hartoularos, Tianna Grant, Raymund Bueno, David S. Lee, John R. Greenland, Yang Sun, Richard Perez, Anton Ogorodnikov, Alyssa Ward, Chun Jimmie Ye, Thiru Ramalingam, Jacqueline M. McBride, Fang Cai, Anastasia Teterina, Min Bao, Larry Tsai, Ivan O. Rosas, Aviv Regev, Sharookh B. Kapadia, Rebecca N. Bauer, Carrie M. Rosenberger, Yumiko Abe-Jones, Michael Adkisson, K. Mark Ansel, Saurabh Asthana, Alexander Beagle, Sharvari Bhide, Cathy Cai, Saharai Caldera, Maria Calvo, Sidney A. Carrillo, Suzanna Chak, Stephanie Christenson, Zachary Collins, Spyros Darmanis, Angela Detweiler, Catherine DeVoe, Walter Eckalbar, Jeremy Giberson, Ana Gonzalez, Gracie Gordon, Paula Hayakawa Serpa, Alejandra Jauregui, Chayse Jones, Serena Ke, Divya Kushnoor, Tasha Lea, Deanna Lee, Aleksandra Leligdowicz, Yale Liu, Salman Mahboob, Lenka Maliskova, Michael Matthay, Elizabeth McCarthy, Priscila Muñoz-Sandoval, Norma Neff, Viet Nguyen, Nishita Nigam, Randy Parada, Maira Phelps, Logan Pierce, Priya Prasad, Sadeed Rashid, Gabriella Reeder, Nicklaus Rodriguez, Bushra Samad, Andrew Schroeder, Cole Shaw, Alan Shen, Austin Sigman, Pratik Sinha, Matthew Spitzer, Sara Sunshine, Kevin Tang, Luz Torres Altamirano, Alexandra Tsitsiklis, Erden Tumurbaatar, Vaibhav Upadhyay, Alexander Whatley, Andrew Willmore, Michael Wilson, Juliane Winkler, Kristine Wong, Kimberly Yee, Michelle Yu, Mingyue Zhou, Wandi S. Zhu
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107813- (2023)
Summary: Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from patients with acute lung injury from SARS-CoV-2 or other causes across
Externí odkaz:
https://doaj.org/article/9fcf76e7c2d9439cbd17b0a0b7fa8d89
Autor:
Vickram Tejwani, Han Woo, Chen Liu, Anna K. Tillery, Amanda J. Gassett, Richard E. Kanner, Eric A. Hoffman, Fernando J. Martinez, Prescott G. Woodruff, R. Graham Barr, Ashraf Fawzy, Kirsten Koehler, Jeffrey L. Curtis, Christine M. Freeman, Christopher B. Cooper, Alejandro P. Comellas, Cheryl Pirozzi, Robert Paine, Donald Tashkin, Jerry A. Krishnan, Coralynn Sack, Nirupama Putcha, Laura M. Paulin, Marina Zusman, Joel D. Kaufman, Neil E. Alexis, Nadia N. Hansel
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Background Airway macrophages (AM), crucial for the immune response in chronic obstructive pulmonary disease (COPD), are exposed to environmental particulate matter (PM), which they retain in their cytoplasm as black carbon (BC). However, wh
Externí odkaz:
https://doaj.org/article/560d7cf59df54945adb8be143473ac12
Autor:
Katherine D. Wick, Aleksandra Leligdowicz, Andrew Willmore, Sidney A. Carrillo, Rajani Ghale, Alejandra Jauregui, Suzanna S. Chak, Viet Nguyen, Deanna Lee, Chayse Jones, Robin Dewar, H. Clifford Lane, Kirsten N. Kangelaris, Carolyn M. Hendrickson, Kathleen D. Liu, Pratik Sinha, David J. Erle, Charles R. Langelier, Matthew F. Krummell, Prescott G. Woodruff, Carolyn S. Calfee, Michael A. Matthay, the COMET Consortium
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-11 (2022)
Abstract Background Studies quantifying SARS-CoV-2 have focused on upper respiratory tract or plasma viral RNA with inconsistent association with clinical outcomes. The association between plasma viral antigen levels and clinical outcomes has not bee
Externí odkaz:
https://doaj.org/article/e599ea26c99e4e01a0e78f4b33fff553
Autor:
Ana I. Hernández Cordero, Chen Xi Yang, Xuan Li, Stephen Milne, Virginia Chen, Zsuzsanna Hollander, Raymond Ng, Gerard J. Criner, Prescott G. Woodruff, Stephen C. Lazarus, John E. Connett, MeiLan K. Han, Fernando J. Martinez, Robert M. Reed, S. F. Paul Man, Janice M. Leung, Don D. Sin
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Chronic obstructive pulmonary disease (COPD) is an age-related condition that has been associated with early telomere attrition; the clinical implications of telomere shortening in COPD are not well known. In this study we aimed t
Externí odkaz:
https://doaj.org/article/2ec17b50b24c4f93b29c56dc46e765e1
Autor:
Al Ozonoff, Joanna Schaenman, Naresh Doni Jayavelu, Carly E. Milliren, Carolyn S. Calfee, Charles B. Cairns, Monica Kraft, Lindsey R. Baden, Albert C. Shaw, Florian Krammer, Harm van Bakel, Denise A. Esserman, Shanshan Liu, Ana Fernandez Sesma, Viviana Simon, David A. Hafler, Ruth R. Montgomery, Steven H. Kleinstein, Ofer Levy, Christian Bime, Elias K. Haddad, David J. Erle, Bali Pulendran, Kari C. Nadeau, Mark M. Davis, Catherine L. Hough, William B. Messer, Nelson I. Agudelo Higuita, Jordan P. Metcalf, Mark A. Atkinson, Scott C. Brakenridge, David Corry, Farrah Kheradmand, Lauren I.R. Ehrlich, Esther Melamed, Grace A. McComsey, Rafick Sekaly, Joann Diray-Arce, Bjoern Peters, Alison D. Augustine, Elaine F. Reed, Matthew C. Altman, Patrice M. Becker, Nadine Rouphael, Chris Bime, Mark M Davis, Kerry McEnaney, Brenda Barton, Claudia Lentucci, Mehmet Saluvan, Ana C. Chang, Annmarie Hoch, Marisa Albert, Tanzia Shaheen, Alvin T. Kho, Sanya Thomas, Jing Chen, Maimouna D. Murphy, Mitchell Cooney, Scott Presnell, Gabriela K. Fragiadakis, Ravi Patel, Leying Guan, Jeremy Gygi, Shrikant Pawar, Anderson Brito, Zain Khalil, Cole Maguire, Slim Fourati, James A. Overton, Randi Vita, Kerstin Westendorf, Ramin Salehi-Rad, Aleksandra Leligdowicz, Michael A. Matthay, Jonathan P. Singer, Kirsten N. Kangelaris, Carolyn M. Hendrickson, Matthew F. Krummel, Charles R. Langelier, Prescott G. Woodruff, Debra L. Powell, James N. Kim, Brent Simmons, I. Michael Goonewardene, Cecilia M. Smith, Mark Martens, Jarrod Mosier, Hiroki Kimura, Amy C. Sherman, Stephen R. Walsh, Nicolas C. Issa, Charles Dela Cruz, Shelli Farhadian, Akiko Iwasaki, Albert I. Ko, Sharon Chinthrajah, Neera Ahuja, Angela J. Rogers, Maja Artandi, Sarah A.R. Siegel, Zhengchun Lu, Douglas A. Drevets, Brent R. Brown, Matthew L. Anderson, Faheem W. Guirgis, Rama V. Thyagarajan, Justin F. Rousseau, Dennis Wylie, Johanna Busch, Saurin Gandhi, Todd A. Triplett, George Yendewa, Olivia Giddings, Evan J. Anderson, Aneesh K. Mehta, Jonathan E. Sevransky, Bernard Khor, Adeeb Rahman, Daniel Stadlbauer, Jayeeta Dutta, Hui Xie, Seunghee Kim-Schulze, Ana Silvia Gonzalez-Reiche, Adriana van de Guchte, Keith Farrugia, Zenab Khan, Holden T. Maecker, David Elashoff, Jenny Brook, Estefania Ramires-Sanchez, Megan Llamas, Adreanne Rivera, Claudia Perdomo, Dawn C. Ward, Clara E. Magyar, Jennifer A. Fulcher, Yumiko Abe-Jones, Saurabh Asthana, Alexander Beagle, Sharvari Bhide, Sidney A. Carrillo, Suzanna Chak, Rajani Ghale, Ana Gonzalez, Alejandra Jauregui, Norman Jones, Tasha Lea, Deanna Lee, Raphael Lota, Jeff Milush, Viet Nguyen, Logan Pierce, Priya A. Prasad, Arjun Rao, Bushra Samad, Cole Shaw, Austin Sigman, Pratik Sinha, Alyssa Ward, Andrew Willmore, Jenny Zhan, Sadeed Rashid, Nicklaus Rodriguez, Kevin Tang, Luz Torres Altamirano, Legna Betancourt, Cindy Curiel, Nicole Sutter, Maria Tercero Paz, Gayelan Tietje-Ulrich, Carolyn Leroux, Jennifer Connors, Mariana Bernui, Michel A. Kutzler, Carolyn Edwards, Edward Lee, Edward Lin, Brett Croen, Nicholas C. Semenza, Brandon Rogowski, Nataliya Melnyk, Kyra Woloszczuk, Gina Cusimano, Mathew R. Bell, Sara Furukawa, Renee McLin, Pamela Marrero, Julie Sheidy, George P. Tegos, Crystal Nagle, Nathan Mege, Kristen Ulring, Vicki Seyfert-Margolis, Michelle Conway, Dave Francisco, Allyson Molzahn, Heidi Erickson, Connie Cathleen Wilson, Ron Schunk, Bianca Sierra, Trina Hughes, Kinga Smolen, Michael Desjardins, Simon van Haren, Xhoi Mitre, Jessica Cauley, Xiaofang Li, Alexandra Tong, Bethany Evans, Christina Montesano, Jose Humberto Licona, Jonathan Krauss, Jun Bai Park Chang, Natalie Izaguirre, Omkar Chaudhary, Andreas Coppi, John Fournier, Subhasis Mohanty, M. Catherine Muenker, Allison Nelson, Khadir Raddassi, Michael Rainone, William E. Ruff, Syim Salahuddin, Wade L. Schulz, Pavithra Vijayakumar, Haowei Wang, Elsio Wunder Jr., H. Patrick Young, Yujiao Zhao, Miti Saksena, Deena Altman, Erna Kojic, Komal Srivastava, Lily Q. Eaker, Maria C. Bermúdez-González, Katherine F. Beach, Levy A. Sominsky, Arman R. Azad, Juan Manuel Carreño, Gagandeep Singh, Ariel Raskin, Johnstone Tcheou, Dominika Bielak, Hisaaki Kawabata, Lubbertus CF Mulder, Giulio Kleiner, Alexandra S. Lee, Evan Do Do, Andrea Fernandes, Monali Manohar, Thomas Hagan, Catherine A. Blish, Hena Naz Din, Jonasel Roque, Samuel Yang, Amanda Brunton, Peter E. Sullivan, Matthew Strnad, Zoe L. Lyski, Felicity J. Coulter, J. Leland Booth, Lauren A. Sinko, Lyle L. Moldawer, Brittany Borresen, Brittney Roth-Manning, Li-Zhen Song, Ebony Nelson, Megan Lewis-Smith, Jacob Smith, Pablo Guaman Tipan, Nadia Siles, Sam Bazzi, Janelle Geltman, Kerin Hurley, Gio Gabriele, Scott Sieg, Tatyana Vaysman, Laurel Bristow, Laila Hussaini, Kieffer Hellmeister, Hady Samaha, Andrew Cheng, Christine Spainhour, Erin M. Scherer, Brandi Johnson, Amer Bechnak, Caroline R. Ciric, Lauren Hewitt, Erin Carter, Nina Mcnair, Bernadine Panganiban, Christopher Huerta, Jacob Usher, Susan Pereira Ribeiro
Publikováno v:
EBioMedicine, Vol 83, Iss , Pp 104208- (2022)
Summary: Background: Better understanding of the association between characteristics of patients hospitalized with coronavirus disease 2019 (COVID-19) and outcome is needed to further improve upon patient management. Methods: Immunophenotyping Assess
Externí odkaz:
https://doaj.org/article/6bb1f29e485b44e3b837f1d761005a73