Zobrazeno 1 - 10
of 134
pro vyhledávání: '"G William Wong"'
Publikováno v:
eLife, Vol 12 (2024)
Genome-wide association studies (GWAS) have identified a large number of candidate genes believed to affect longitudinal bone growth and bone mass. One of these candidate genes, TMEM263, encodes a poorly characterized plasma membrane protein. Single
Externí odkaz:
https://doaj.org/article/79f38225ad9b44c9aba3a5a68c278bad
Autor:
Dylan C Sarver, Cheng Xu, Susana Rodriguez, Susan Aja, Andrew E Jaffe, Feng J Gao, Michael Delannoy, Muthu Periasamy, Yasuhiro Kazuki, Mitsuo Oshimura, Roger H Reeves, G William Wong
Publikováno v:
eLife, Vol 12 (2023)
The consequences of aneuploidy have traditionally been studied in cell and animal models in which the extrachromosomal DNA is from the same species. Here, we explore a fundamental question concerning the impact of aneuploidy on systemic metabolism us
Externí odkaz:
https://doaj.org/article/3aeea4fdb24949308434aa922bedcafd
Autor:
Haojun Yang, Martina Ralle, Michael J Wolfgang, Neha Dhawan, Jason L Burkhead, Susana Rodriguez, Jack H Kaplan, G William Wong, Norman Haughey, Svetlana Lutsenko
Publikováno v:
PLoS Biology, Vol 16, Iss 9, p e2006519 (2018)
Copper (Cu) has emerged as an important modifier of body lipid metabolism. However, how Cu contributes to the physiology of fat cells remains largely unknown. We found that adipocytes require Cu to establish a balance between main metabolic fuels. Di
Externí odkaz:
https://doaj.org/article/f6306c1815e54a438c192f951701973e
Autor:
Risa M Wolf, Kimberley E Steele, Leigh A Peterson, Thomas H Magnuson, Michael A Schweitzer, G William Wong
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133955 (2015)
C1q/TNF-related protein-3 (CTRP3) is a novel adipokine that lowers blood glucose levels, reduces liver triglyceride synthesis, and is protective against hepatic steatosis in diet-induced obese mouse models. We hypothesized that higher circulating ser
Externí odkaz:
https://doaj.org/article/02dd87a3a26d4e90b30646be6d2e2e03
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88535 (2014)
CTRP2 is a secreted plasma protein of the C1q family that enhances glycogen deposition and fat oxidation in cultured myotubes. Its in vivo metabolic function, however, has not been established. We show here that acute and chronic metabolic perturbati
Externí odkaz:
https://doaj.org/article/9ce47b23216e4e80835f29ce764b70f8
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80781 (2013)
During development, prenatal and postnatal factors program homeostatic set points to regulate food intake and body weight in the adult. Combinations of genetic and environmental factors contribute to the development of neural circuitry that regulates
Externí odkaz:
https://doaj.org/article/352c6d2358244379b36ea3d146e43662
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62862 (2013)
C1q/TNF-related protein 13 (CTRP13), a hormone secreted by adipose tissue (adipokines), helps regulate glucose metabolism in peripheral tissues. We previously reported that CTRP13 expression is increased in obese and hyperphagic leptin-deficient mice
Externí odkaz:
https://doaj.org/article/83d881fedf33463b971103ab892d8ffd
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12765 (2010)
The mammalian otoconial membrane is a dense extracellular matrix containing bio-mineralized otoconia. This structure provides the mechanical stimulus necessary for hair cells of the vestibular maculae to respond to linear accelerations and gravity. I
Externí odkaz:
https://doaj.org/article/6302ab1f0daa41b3b95154b4044771f4
Autor:
Bige Ozkan, Amelia S Wallace, Carine Hamo, Risa Wolf, Justin B Echouffo Tcheugui, Alexander Arking, Gary Gerstenblith, Xin Chu, G. Craig Wood, Peter Benotti, G William Wong, Josef Coresh, Chiadi E Ndumele
Publikováno v:
Circulation. 147
Background: Adipokines mediate many metabolic effects of adipose tissue. While regional body composition is associated with metabolic risk, it is unclear if metabolic risk associations differ for adipokine expression in visceral and subcutaneous tiss
Publikováno v:
Hormone Research in Paediatrics. 95:43-50
Introduction: Pediatric obesity and diabetes has increased over the last several decades. While the role of common adipokines on metabolic parameters has been well studied in adults, the relationship of novel adipokines and hepatokines in pediatric t