Zobrazeno 1 - 10
of 354
pro vyhledávání: '"G William Rebeck"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
Externí odkaz:
https://doaj.org/article/07071b2f1b944a94845e46756033e5af
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-17 (2024)
Abstract Microglia are highly dynamic cells that play a critical role in tissue homeostasis through the surveillance of brain parenchyma and response to cues associated with damage. Aging and APOE4 genotype are the strongest risk factors for Alzheime
Externí odkaz:
https://doaj.org/article/7936248805824daca77f40ec975cc4d4
Autor:
Griffin A. Greco, Mitchell Rock, Matthew Amontree, Maria Fe Lanfranco, Holly Korthas, Sung Hyeok Hong, R. Scott Turner, G. William Rebeck, Katherine Conant
Publikováno v:
Neurobiology of Disease, Vol 179, Iss , Pp 106057- (2023)
The APOE4 allele increases the risk for Alzheimer's disease (AD) in a dose-dependent manner and is also associated with cognitive decline in non-demented elderly controls. In mice with targeted gene replacement (TR) of murine APOE with human APOE3 or
Externí odkaz:
https://doaj.org/article/fd4b70330d404358b61b5d8721a3fd22
Autor:
Elena Galvano, Harshul Pandit, Jordy Sepulveda, Christi Anne S. Ng, Melanie K. Becher, Jeanne S. Mandelblatt, Kathleen Van Dyk, G. William Rebeck
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionTamoxifen is a common treatment for estrogen receptor-positive breast cancer. While tamoxifen treatment is generally accepted as safe, there are concerns about adverse effects on cognition.MethodsWe used a mouse model of chronic tamoxifen
Externí odkaz:
https://doaj.org/article/0caf651bc3014370b5cc81bca03cb233
Autor:
Christi Anne S. Ng, Lucas P. Biran, Elena Galvano, Jeanne Mandelblatt, Stefano Vicini, G. William Rebeck
Publikováno v:
Neurobiology of Disease, Vol 175, Iss , Pp 105915- (2022)
Many cancer survivors experience cancer-related cognitive impairment (CRCI), which is characterized by problems of attention, working memory, and executive function following chemotherapy and/or hormonal treatment. APOE4, the strongest genetic risk f
Externí odkaz:
https://doaj.org/article/0a4103d8ac614419bf60644ba43db267
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)
Abstract Background APOE 4 is the strongest genetic risk factor for Alzheimer’s disease (AD), and obesity is a strong environmental risk factor for AD. These factors result in multiple central nervous system (CNS) disturbances and significantly inc
Externí odkaz:
https://doaj.org/article/8ea9e138801e4b9a957c50f4e333d0f8
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252958 (2021)
Spatial inhibition of return (IOR) refers to the phenomenon by which individuals are slower to respond to stimuli appearing at a previously cued location compared to un-cued locations. Here with a group of older adults (n = 56, 58-80 (67.9±5.2) year
Externí odkaz:
https://doaj.org/article/742a30dabad84377ad5ab5e2b59ce884
Autor:
Mitsuru Shinohara, Takahisa Kanekiyo, Masaya Tachibana, Aishe Kurti, Motoko Shinohara, Yuan Fu, Jing Zhao, Xianlin Han, Patrick M Sullivan, G William Rebeck, John D Fryer, Michael G Heckman, Guojun Bu
Publikováno v:
eLife, Vol 9 (2020)
Although the ε2 allele of apolipoprotein E (APOE2) benefits longevity, its mechanism is not understood. The protective effects of the APOE2 on Alzheimer’s disease (AD) risk, particularly through their effects on amyloid or tau accumulation, may co
Externí odkaz:
https://doaj.org/article/546486e15f5a428a8f12cebb5e03daec
Autor:
Sarah A. Flowers, G. William Rebeck
Publikováno v:
Neurobiology of Disease, Vol 136, Iss , Pp 104724- (2020)
The APOE4 protein affects the primary neuropathological markers of Alzheimer's disease (AD): amyloid plaques, neurofibrillary tangles, and gliosis. These interactions have been investigated to understand the strong effect of APOE genotype on risk of
Externí odkaz:
https://doaj.org/article/cbd468a3a1634b8b93bbcfd21a28e170
Publikováno v:
Cancer Research. 82:P1-08
Background: The human apolipoprotein E (APOE) gene has three major allelic variants: APOE2, -E3 and -E4. Carriers of the E4 allele are at increased risk for Alzheimer’s and other age-related neurodegenerative disorders. Recently, APOE4 has been ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11456623b74d2b27137210f69ae86ba2
https://doi.org/10.1158/1538-7445.sabcs21-p1-08-05
https://doi.org/10.1158/1538-7445.sabcs21-p1-08-05