Výsledky vyhledávání - "G Wiederrecht"

T cell responses in calcineurin A alpha-deficient mice

Autor: Abul K. Abbas, G. Wiederrecht, Bo Zhang, Dan Ladd, Jianzhu Chen, E Li, Christine E. Seidman, G J Zimmer, E A O'Neill, Frederick W. Alt, J Cryan, Jonathan G. Seidman

Publikováno v: The Journal of Experimental Medicine

We have created embryonic stem (ES) cells and mice lacking the predominant isoform (alpha) of the calcineurin A subunit (CNA alpha) to study the role of this serine/threonine phosphatase in the immune system. T and B cell maturation appeared to be no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2818b8b8a80fe673bfe1b76aecf9b312
https://doi.org/10.1084/jem.183.2.413

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The calcium release channel of sarcoplasmic reticulum is modulated by FK-506-binding protein. Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum

Autor: A.P. Timerman, E Ogunbumni, A R Marks, Sidney Fleischer, G Wiederrecht, E Freund

Publikováno v: Journal of Biological Chemistry. 268:22992-22999

The ryanodine receptor/calcium release channel (CRC) of rabbit skeletal muscle terminal cisternae (TC) of sarcoplasmic reticulum (SR) has been found to be tightly associated with FK-506 binding protein (FKBP-12), the cytosolic receptor (immunophilin)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eff73765693007857be6c2d8750bdb3f
https://doi.org/10.1016/s0021-9258(19)49416-7

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Akademický článek

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Yeast immunophilins: purification and assay of yeast FKBP12

Autor: G, Wiederrecht, J J, Siekierka

Publikováno v: Methods in enzymology. 290

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c49b307bcfcfea0fedc7b339eb2612f1
https://pubmed.ncbi.nlm.nih.gov/9534152

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Akademický článek

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Mixed agonist/antagonist activity of an FK-506-related immunosuppressant: biological and biochemical characterization

Autor: F J, Dumont, H, Ok, S, Lin, C A, Kastner, J, Cryan, M M, Martin, G, Wiederrecht, M J, Staruch

Publikováno v: The Journal of pharmacology and experimental therapeutics. 276(3)

FK-506 blocks T cell activation by preventing lymphokine gene transcription through formation of a complex with FKBP12 that inhibits calcineurin phosphatase activity. Immunosuppressive FK-506 analogs (agonists) have been generated whose potency corre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3e83efc7f7669392b0d922571c1aee74
https://pubmed.ncbi.nlm.nih.gov/8786538

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Characterization of an exchange reaction between soluble FKBP-12 and the FKBP.ryanodine receptor complex. Modulation by FKBP mutants deficient in peptidyl-prolyl isomerase activity

Autor: A P, Timerman, G, Wiederrecht, A, Marcy, S, Fleischer

Publikováno v: The Journal of biological chemistry. 270(6)

FKBP-12 (FKBP), the soluble receptor for the immunosuppresant drug FK-506, is tightly bound to the calcium release channel (CRC)/ryanodine receptor (RyR) of skeletal muscle terminal cisternae (TC) of sarcoplasmic reticulum with a stoichiometry of 4 m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::48875654d9b35d771f0b2ddf8246dd5a
https://pubmed.ncbi.nlm.nih.gov/7531689

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Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes

Autor: W G, Morice, G, Wiederrecht, G J, Brunn, J J, Siekierka, R T, Abraham

Publikováno v: The Journal of biological chemistry. 268(30)

The immunosuppressant rapamycin (RAP) is a potent inhibitor of the entry of interleukin (IL)-2-stimulated T cells into S-phase. Earlier results indicated that RAP treatment arrested the growth of the murine IL-2-dependent T cell line CTLL-2 in late G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1cf2a4e80b339ab26a2f59a517993457
https://pubmed.ncbi.nlm.nih.gov/8226784

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FK-506-binding protein: three-dimensional structure of the complex with the antagonist L-685,818

Autor: J W, Becker, J, Rotonda, B M, McKeever, H K, Chan, A I, Marcy, G, Wiederrecht, J D, Hermes, J P, Springer

Publikováno v: The Journal of biological chemistry. 268(15)

L-685,818 differs only slightly in structure from the immunosuppressive drug FK-506, and both compounds bind with comparable affinity to the 12-kDa FK-506-binding protein (FKBP12), the major intracellular receptor for the drug. Despite these similari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::daba5ba4c879fa51f3e4c496d5598c8a
https://pubmed.ncbi.nlm.nih.gov/7684380

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Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes

Autor: W G, Morice, G J, Brunn, G, Wiederrecht, J J, Siekierka, R T, Abraham

Publikováno v: The Journal of biological chemistry. 268(5)

The macrolide rapamycin (RAP) is a potent inhibitor of interleukin-2 (IL-2)-induced T-cell proliferation. Current models suggest that RAP, when complexed to its intracellular receptor, FK506-binding protein, interferes with an IL-2 receptor-coupled s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0e7fe382b9d39f9b36dd2c304ab089b
https://pubmed.ncbi.nlm.nih.gov/8429048

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