Zobrazeno 1 - 10
of 317
pro vyhledávání: '"G Whalen"'
Autor:
Parisa Hosseinzadeh, Paris R. Watson, Timothy W. Craven, Xinting Li, Stephen Rettie, Fátima Pardo-Avila, Asim K. Bera, Vikram Khipple Mulligan, Peilong Lu, Alexander S. Ford, Brian D. Weitzner, Lance J. Stewart, Adam P. Moyer, Maddalena Di Piazza, Joshua G. Whalen, Per Jr. Greisen, David W. Christianson, David Baker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Cyclic peptides are of particular interest due to their pharmacological properties, but their design for binding to a target protein is challenging. Here, the authors present a computational “anchor extension” methodology for de novo design of cy
Externí odkaz:
https://doaj.org/article/603d7c9cce674f14a81d38644247320d
Autor:
Ema T Crooks, Tommy Tong, Bimal Chakrabarti, Kristin Narayan, Ivelin S Georgiev, Sergey Menis, Xiaoxing Huang, Daniel Kulp, Keiko Osawa, Janelle Muranaka, Guillaume Stewart-Jones, Joanne Destefano, Sijy O'Dell, Celia LaBranche, James E Robinson, David C Montefiori, Krisha McKee, Sean X Du, Nicole Doria-Rose, Peter D Kwong, John R Mascola, Ping Zhu, William R Schief, Richard T Wyatt, Robert G Whalen, James M Binley
Publikováno v:
PLoS Pathogens, Vol 11, Iss 5, p e1004932 (2015)
Eliciting broad tier 2 neutralizing antibodies (nAbs) is a major goal of HIV-1 vaccine research. Here we investigated the ability of native, membrane-expressed JR-FL Env trimers to elicit nAbs. Unusually potent nAb titers developed in 2 of 8 rabbits
Externí odkaz:
https://doaj.org/article/65b7f896418649c1899f642d72673ccb
Autor:
Johannes S Gach, Heribert Quendler, Tommy Tong, Kristin M Narayan, Sean X Du, Robert G Whalen, James M Binley, Donald N Forthal, Pascal Poignard, Michael B Zwick
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72054 (2013)
Primary isolates of HIV-1 resist neutralization by most antibodies to the CD4 binding site (CD4bs) on gp120 due to occlusion of this site on the trimeric spike. We describe 1F7, a human CD4bs monoclonal antibody that was found to be exceptionally pot
Externí odkaz:
https://doaj.org/article/cce40e1dc2ad4d5893581ac52a615e3f
Autor:
Kristin M Narayan, Nitish Agrawal, Sean X Du, Janelle E Muranaka, Katherine Bauer, Daniel P Leaman, Pham Phung, Kay Limoli, Helen Chen, Rebecca I Boenig, Terri Wrin, Michael B Zwick, Robert G Whalen
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52732 (2013)
Development of a vaccine for HIV-1 requires a detailed understanding of the neutralizing antibody responses that can be experimentally elicited to difficult-to-neutralize primary isolates. Rabbits were immunized with the gp120 subunit of HIV-1 JR-CSF
Externí odkaz:
https://doaj.org/article/373c90d7de20468bbbf0e4d14fa246f4
Autor:
Robert G. Whalen
Publikováno v:
Emerging Infectious Diseases, Vol 2, Iss 3, Pp 168-175 (1996)
A novel and powerful method for vaccine research, colloquially known as DNA vaccines, involves the deliberate introduction into tissues of a DNA plasmid carrying an antigen-coding gene that transfects cells in vivo and results in an immune response.
Externí odkaz:
https://doaj.org/article/8ee982eeaa1549b4beeef66d7f160879
Autor:
Maddalena Di Piazza, Brian D. Weitzner, Joshua G Whalen, Asim K. Bera, David W. Christianson, Xinting Li, David Baker, Peilong Lu, Stephen A. Rettie, Adam Moyer, Paris R. Watson, Vikram Khipple Mulligan, Per Jr Greisen, Alex Ford, Parisa Hosseinzadeh, Timothy W. Craven, Lance Stewart, Fátima Pardo-Avila
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Despite recent success in computational design of structured cyclic peptides, de novo design of cyclic peptides that bind to any protein functional site remains difficult. To address this challenge, we develop a computational “anchor extension” m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f14e485ca365a0b47e5f927cb9cd98
https://pubmed.ncbi.nlm.nih.gov/34099674
https://pubmed.ncbi.nlm.nih.gov/34099674
Autor:
Sean X Du, Li Xu, Wenge Zhang, Susan Tang, Rebecca I Boenig, Helen Chen, Ellaine B Mariano, Michael B Zwick, Paul W H I Parren, Dennis R Burton, Terri Wrin, Christos J Petropoulos, John A Ballantyne, Michael Chambers, Robert G Whalen
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20927 (2011)
A prophylactic vaccine is needed to slow the spread of HIV-1 infection. Optimization of the wild-type envelope glycoproteins to create immunogens that can elicit effective neutralizing antibodies is a high priority. Starting with ten genes encoding s
Externí odkaz:
https://doaj.org/article/8aeb5bb4d0ea428fa8ca3ec1ac121e60
Autor:
Nitish Agrawal, Daniel P Leaman, Eric Rowcliffe, Heather Kinkead, Raman Nohria, Junya Akagi, Katherine Bauer, Sean X Du, Robert G Whalen, Dennis R Burton, Michael B Zwick
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21339 (2011)
The HIV-1 envelope glycoprotein (Env) spike is challenging to study at the molecular level, due in part to its genetic variability, structural heterogeneity and lability. However, the extent of lability in Env function, particularly for primary isola
Externí odkaz:
https://doaj.org/article/0bc298437a524bf4a846d93e17880be2
Autor:
James M. Binley, Tommy Tong, William R. Schief, Samantha L. Grimley, Robert G. Whalen, Yang D. Dai, Ema T. Crooks, Daniel W. Kulp, Keiko Osawa, Sergey Menis
Publikováno v:
Virology. 505:193-209
Previously, VLPs bearing JR-FL strain HIV-1 Envelope trimers elicited potent neutralizing antibodies (nAbs) in 2/8 rabbits (PLoS Pathog 11(5): e1004932) by taking advantage of a naturally absent glycan at position 197 that borders the CD4 binding sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18698d86850c909ab3b57f99cca64946
https://doi.org/10.1016/j.virol.2017.02.024
https://doi.org/10.1016/j.virol.2017.02.024
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