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pro vyhledávání: '"G W K van Dedem"'
Publikováno v:
Journal of Thrombosis and Haemostasis, 1(5), 907-914. Wiley
Summary. Background: Heparins in clinical use differ considerably as to mode of preparation, molecular weight distribution and pharmacodynamic properties. Objectives: Find a common basis for their anticoagulant action. Methods: In 50 fractions of vir
Autor:
G W K van Dedem, I M A Verhamme
Publikováno v:
XIth International Congress on Thrombosis and Haemostasis.
The knowledge of the pH and ionic strength dependence of kcat and Km for the hydrolysis of S2238 (HD-phe-pip-arg-pNA.2HC1) by alpha-thrombin is essential in determining optimal reaction conditions of residual enzyme in systems where also protease inh
Autor:
G W K van Dedem, I M A Verhamme
Publikováno v:
XIth International Congress on Thrombosis and Haemostasis.
Heparin cofactor II (HCII) inhibits alpha-thrombin (Ila) with formation of a 1:1 complex.The inhibition is accelerated by heparin and dermatan sulfate (DS).The present study describes the pH and ionic strength dependence of the second order inactivat