Zobrazeno 1 - 10 of 61 pro vyhledávání: '"G W, Lucier"'
2
Induced gene transcription: implications for biomarkers
Autor: A M Tritscher, J Vanden Heuvel, D B Tully, C H Sewall, G W Lucier, D A Bell, G C Clark
Publikováno v: Clinical Chemistry. 41:1829-1834
Numerous xenobiotics regulate cellular functions by altering transcription of target genes. Use of sensitive and specific biomarkers based on gene transcript levels may help clarify the shape of the dose-response curve in the low-dose region associat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8eccf122fd663156ce7e24571b3c818
https://doi.org/10.1093/clinchem/41.12.1829
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4
Ovarian tumors in rats induced by chronic 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
Autor: B J, Davis, E A, Mccurdy, B D, Miller, G W, Lucier, A M, Tritscher
Publikováno v: Cancer research. 60(19)
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a multispecies reproductive toxicant, and it has been recently classified by IARC as a known human carcinogen. Here, we report that TCDD promotes the development of ovarian tumors in an initiation-promoti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::df8a9340e0b6217c880fcbe2775b7e70
https://pubmed.ncbi.nlm.nih.gov/11034082
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5
Quantitative analysis of constitutive and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cytochrome P450 1B1 expression in human lymphocytes
Autor: D L, Spencer, S A, Masten, K M, Lanier, X, Yang, J A, Grassman, C R, Miller, T R, Sutter, G W, Lucier, N J, Walker
Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 8(2)
Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin) results in a broad spectrum of biological responses, including altered metabolism, disruption of normal hormone signaling pathways, reproductive and developmental effects, and cancer. C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::549e1ea9bc6d9310032047ec2e8b6a1c
https://pubmed.ncbi.nlm.nih.gov/10067811
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8
Increased oxidative DNA damage in livers of 2,3,7,8-tetrachlorodibenzo-p-dioxin treated intact but not ovariectomized rats
Autor: A M, Tritscher, A M, Seacat, J D, Yager, J D, Groopman, B D, Miller, D, Bell, T R, Sutter, G W, Lucier
Publikováno v: Cancer letters. 98(2)
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a more potent hepatocarcinogen in female than in male or ovariectomized rats. A possible mechanism for this increased sensitivity is through enhanced metabolic activation of estrogens by TCDD-induced enzy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ed598f130fd03e53033c465c79d2827
https://pubmed.ncbi.nlm.nih.gov/8556712
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10
Induced gene transcription: implications for biomarkers
Autor: C H, Sewall, D A, Bell, G C, Clark, A M, Tritscher, D B, Tully, J, Vanden Heuvel, G W, Lucier
Publikováno v: Clinical chemistry. 41(12 Pt 2)
Numerous xenobiotics regulate cellular functions by altering transcription of target genes. Use of sensitive and specific biomarkers based on gene transcript levels may help clarify the shape of the dose-response curve in the low-dose region associat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d0758e00694a61bdd62e0a8e0d11f1cf
https://pubmed.ncbi.nlm.nih.gov/7497640
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