Zobrazeno 1 - 10
of 11
pro vyhledávání: '"G W, Krystal"'
Publikováno v:
Cell Death & Disease
The sensitivity to ABT-737, a prototype BH3 mimetic drug, varies in a broad range in small cell lung cancer (SCLC) cells. We have previously shown that the expression of Noxa, a BH3-only pro-apoptotic BCL-2 family protein, is the critical determinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2310ec72402aade7b0bf62765daddd7f
https://pubmed.ncbi.nlm.nih.gov/24525728
https://pubmed.ncbi.nlm.nih.gov/24525728
Publikováno v:
Molecular and Cellular Biology. 10:4180-4191
Nuclear runoff transcription studies revealed nearly equivalent sense and antisense transcription across exon 1 of the N-myc locus. Antisense primary transcription initiates at multiple sites in intron 1 and gives rise to stable polyadenylated and no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f2f5c1a6b513d3930999994654a264e
https://doi.org/10.1128/mcb.10.8.4180
https://doi.org/10.1128/mcb.10.8.4180
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(8)
At least 70% of small cell lung cancers express the Kit receptor tyrosine kinase and its ligand, stem cell factor (SCF). Numerous lines of evidence have demonstrated that this coexpression constitutes a functional autocrine loop, suggesting that inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91b4298dd88eb6bec21340da86a55181
https://pubmed.ncbi.nlm.nih.gov/10955770
https://pubmed.ncbi.nlm.nih.gov/10955770
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 11(6)
Small cell lung cancer (SCLC) is characterized by multiple genetic alterations that include inactivation of the retinoblastoma protein (Rb), the establishment of several autocrine loops including that induced by coexpression of stem cell factor (SCF)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::48bd76b5a3bdbf3b5d24fbf47c0ff3a5
https://pubmed.ncbi.nlm.nih.gov/10910097
https://pubmed.ncbi.nlm.nih.gov/10910097
Publikováno v:
Blood. 92(11)
The receptor tyrosine kinase c-kit is necessary for normal hematopoiesis, the development of germ cells and melanocytes, and the pathogenesis of certain hematologic and nonhematologic malignancies. To better understand the regulation of the c-kit gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b5fa043b4f2005d8900026da395a01c0
https://pubmed.ncbi.nlm.nih.gov/9834219
https://pubmed.ncbi.nlm.nih.gov/9834219
Publikováno v:
Cancer research. 58(20)
At least 70% of small cell lung cancers (SCLCs) express the Kit receptor tyrosine kinase and its ligand, stem cell factor (SCF). In an effort to define the signal transduction pathways activated by Kit in SCLC, we focused on Src family kinases and, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::925c3d4ec81c0300bc5893108fbd0caf
https://pubmed.ncbi.nlm.nih.gov/9788619
https://pubmed.ncbi.nlm.nih.gov/9788619
Publikováno v:
Cancer research. 57(11)
Coexpression of the Kit receptor tyrosine kinase and its ligand, stem cell factor (SCF), occurs in a high proportion of small cell lung cancers (SCLCs) and drives an autocrine loop that enhances proliferation. To determine whether this autocrine loop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f22940cc2d83f0ed59c6c8fde11e9919
https://pubmed.ncbi.nlm.nih.gov/9187122
https://pubmed.ncbi.nlm.nih.gov/9187122
Publikováno v:
Cancer research. 56(2)
At least 70% of small cell lung cancer (SCLC) tumors and tumor-derived cell lines coexpress the genes for stem cell factor (SCF) and its receptor, the c-kit proto-oncogene. To assess the impact of coexpression of the growth factor and receptor on SCL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::72ab4eb9ad94bf8c464692de31f2f83e
https://pubmed.ncbi.nlm.nih.gov/8542594
https://pubmed.ncbi.nlm.nih.gov/8542594
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 6(6)
Expression of the c-kit tyrosine kinase growth factor receptor has been reported in some breast tumors; however, no data exist concerning expression of its ligand, stem cell factor. The aim of this study was to determine how frequently the c-kit and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9cc2738807da9d3b78797542d40d1ecd
https://pubmed.ncbi.nlm.nih.gov/7545433
https://pubmed.ncbi.nlm.nih.gov/7545433
Autor:
B C, Armstrong, G W, Krystal
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 3(6)
The N-myc oncogene has been implicated in the pathogenesis of a number of human tumors, including childhood neuroblastoma and adult small cell lung cancer. We have isolated and characterized complementary DNA clones derived from a transcription unit,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ac2c75e4a2a2738bd887b1583b0df06
https://pubmed.ncbi.nlm.nih.gov/1419902
https://pubmed.ncbi.nlm.nih.gov/1419902