Zobrazeno 1 - 10
of 17
pro vyhledávání: '"G W, Koszalka"'
Autor:
G S Lowell, John Milton, David I. Stuart, Joseph H. Chan, George Andrew Freeman, S S Gonzales, Steven A. Short, Jingshan Ren, Andrew L. Hopkins, K L Creech, Richard J. Hazen, R G Ferris, G W Koszalka, L T Schaller, G B Roberts, Cowan, C W Andrews Iii, Kurt Weaver, L R Boone, David K. Stammers, D J Reynolds
HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) are part of the combination therapy currently used to treat HIV infection. The features of a new NNRTI drug for HIV treatment must include selective potent activity against both wild-type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba0381a0617d10120e121697f22e025
https://doi.org/10.1021/jm040072r
https://doi.org/10.1021/jm040072r
Autor:
Dennis C. Liotta, C. L. Burns, L. E. Strange, G. W. Koszalka, Raymond F. Schinazi, L. K. Hoong
Publikováno v:
ChemInform. 24
Autor:
S. D. Chamberlain, A. R. Moorman, L. A. Jones, P. de Miranda, D. J. Reynolds, G. W. Koszalka, T. A. Krenitsky
Publikováno v:
Antiviral Chemistry and Chemotherapy. 3:371-378
6-Methoxypurine arabinoside [9-(β-D-arabinofuranosyl)-6-methoxy-9H-purine; 1] is a potent and selective agent against varicella-zoster virus in vitro. Studies in the rat indicated that extensive first pass metabolism of this nucleoside occurred afte
Autor:
G B, Roberts, J A, Fyfe, S A, McKee, S G, Rahim, S M, Daluge, M R, Almond, J L, Rideout, G W, Koszalka, T A, Krenitsky
Publikováno v:
Biochemical pharmacology. 46(12)
The varicella-zoster virus (VZV) thymidine kinase (TK) EC 2.7.2.21) catalyzes the phosphorylation of many anti-VZV nucleosides. Purified, bacterially expressed VZV TK was characterized with regard to N-terminal amino acid sequence, pI value, pH optim
Publikováno v:
Molecular pharmacology. 41(5)
The membrane permeation characteristics of 5'-deoxythymidine (5'-ddThd) and 5'-azido-5'-deoxythymidine (5'-N3-5'-ddThd) were investigated in human erythrocytes, with an inhibitor-stop assay, at 20 degrees. Uptake of both nucleoside analogs occurred w
Autor:
T. A. Krenitsky, G. W. Koszalka
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 19:xiii-xiv
Publikováno v:
The Journal of biological chemistry. 265(23)
The three-dimensional structure of thymidine phosphorylase from Escherichia coli has been determined at 2.8 A resolution using multiple-isomorphous-replacement techniques. The amino acid sequence deduced from the deoA DNA sequence is also reported. T
Autor:
G W Koszalka, T A Krenitsky
Publikováno v:
Journal of Biological Chemistry. 254:8185-8193
Publikováno v:
The Journal of biological chemistry. 262(6)
Crystals of uridine phosphorylase from Escherichia coli K12 have been grown from solutions of polyethylene glycol 4000. The crystals are trigonal, space group R3; the hexagonal axes are a = 154.4 A and c = 49.4 A. The crystals are quite stable to x-r
Publikováno v:
Advances in experimental medicine and biology.