Zobrazeno 1 - 10
of 43
pro vyhledávání: '"G W, John"'
Publikováno v:
Archives of Environmental & Occupational Health. 69:69-80
Hearing loss from occupational noise exposure is a significant occupational health problem, requiring effective health and safety strategies. Essential to this is an understanding of the noise exposure of workers and the use of hearing protection equ
Autor:
G. W. John, P. De Vries, J. P. C. Heiligers, Kapil Kapoor, P.R. Saxena, Beril Tom, Edwin W Willems
Publikováno v:
Cephalalgia, 22, 37-47. SAGE Publications Ltd
We investigated the effects of donitriptan, which possesses a uniquely high affinity and efficacy at 5-HT1B/1D receptors, on carotid and systemic haemodynamics in anaesthetized pigs. Donitriptan (0.16-100 μg kg-1, i.v.) dose-dependently decreased to
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 358:608-615
The putative coupling between stably expressed recombinant h 5-HT1B or h 5-HT1D receptors and K+ channels which regulate excitability was investigated in C6 glioma cells. Outward K+ currents (IK) were examined in nontransfected C6 glioma cells and in
Autor:
Christiane Palmier, JP Valentin, C. Fourrier, G. W. John, M. Perez, I. Sigogneau, S Halazy, Petrus J. Pauwels, N Ayerbe
Publikováno v:
European Journal of Medicinal Chemistry. 32:129-134
Summary The design and synthesis of a new series of anilide derivatives of serotonin is described. Binding affinity and intrinsic activity were evaluated at cloned human 5-HTIDα, 5-HTIDβ and 5-HTIA receptors. Modification of the terminal substituen
Publikováno v:
Fundamental & Clinical Pharmacology. 10:467-473
We examined the effects of the benzoylguanidine derivative HOE 694, an inhibitor of Na(+)-H+ exchange, against veratrine-induced diastolic contractures and action potentials recorded in rat isolated left atria. Concentration-dependent protective effe
Autor:
Christiane Palmier, Jean-Pierre Valentin, Serge Halazy, Isabelle Pallard, Petrus J. Pauwels, Jean Martinez, G. W. John, C. Fourrier, Régine Bonnafous, Michel Perez
Publikováno v:
Journal of Medicinal Chemistry. 39:4920-4927
A series of serotonin dimers of formula 4 in which two serotonin moeities are linked together through their 5-hydroxyl residue has been prepared and evaluated as 5-HT(1B/1D) receptor agonists. Binding experiments at cloned human 5-HT(1B), 5-HT(1D), a
Publikováno v:
Journal of Cardiovascular Pharmacology. 26:803-809
Action potential duration (APD) lengthening is believed to underlie the cardiac arrhythmogenicity of ketanserin, a serotonin (5-HT)2A/2C receptor antagonist. We wished to determine (a) whether this activity involves blockade of 5-HT2A/2C receptors an
Publikováno v:
Cardiovascular Research. 30:689-696
Objective: In isolated, Langendorff-perfused hearts in the early stages of atherosclerosis from rabbits exposed to hypercholesterolaemia induced by 2% cholesterol feeding for 6 weeks ( n = 23), and age-matched normal controls fed standard chow ( n =
Autor:
C. Fourrier, G. W. John, Jean-Pierre Valentin, Petrus J. Pauwels, Michel Perez, I. Sigogneau, Christiane Palmier, Serge Halazy
Publikováno v:
Journal of Medicinal Chemistry. 38:3602-3607
A series of new arylpiperazide derivatives of serotonin has been prepared and evaluated as 5-HT 1D receptor agonists. Binding experiments at cloned human 5-HT 1Dα , 5-HT 1Dβ , and 5-HT 1A receptors show that all the compounds are very potent and se
Autor:
G. W. John, Serge Halazy, Jean-Pierre Valentin, Michel Perez, Petrus J. Pauwels, Christiane Palmier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:663-666
New 5-O-carboxymethyl piperazide derivatives of tryptamine (6a-d) have been prepared in 4 steps from serotonin as 5-HT1D receptors agonists. Binding studies with cloned human 5-HT1Dα and 5-HT1Dβ receptors demonstrate that these derivatives are high