Výsledky vyhledávání

Differentiation of the mononuclear phagocyte system during mouse embryogenesis: the role of transcription factor PU.1

Autor: A M, Lichanska, C M, Browne, G W, Henkel, K M, Murphy, M C, Ostrowski, S R, McKercher, R A, Maki, D A, Hume

Publikováno v: Blood. 94(1)

During mouse embryogenesis, macrophage-like cells arise first in the yolk sac and are produced subsequently in the liver. The onset of liver hematopoiesis is associated with the transition from primitive to definitive erythrocyte production. This rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6153510dee9f18c3aaee6af54677e036
https://pubmed.ncbi.nlm.nih.gov/10381505

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Commitment to the monocytic lineage occurs in the absence of the transcription factor PU.1

Autor: G W, Henkel, S R, McKercher, P J, Leenen, R A, Maki

Publikováno v: Blood. 93(9)

Mice homozygous for the disruption of the PU.1 (Spi-1) gene do not produce mature macrophages. In determining the role of PU.1 in macrophage differentiation, the present study investigated whether or not there was commitment to the monocytic lineage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f6f2285de926ec5c6141c3cc8ae0e0f1
https://pubmed.ncbi.nlm.nih.gov/10216079

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Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities

Autor: S R, McKercher, B E, Torbett, K L, Anderson, G W, Henkel, D J, Vestal, H, Baribault, M, Klemsz, A J, Feeney, G E, Wu, C J, Paige, R A, Maki

Publikováno v: The EMBO journal. 15(20)

PU.1 is a member of the ets family of transcription factors and is expressed exclusively in cells of the hematopoietic lineage. Mice homozygous for a disruption in the PU.1 DNA binding domain are born alive but die of severe septicemia within 48 h. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::367c53f90bcba7ecc4a95c167c66db4a
https://pubmed.ncbi.nlm.nih.gov/8896458

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PU.1 but not ets-2 is essential for macrophage development from embryonic stem cells

Autor: G W, Henkel, S R, McKercher, H, Yamamoto, K L, Anderson, R G, Oshima, R A, Maki

Publikováno v: Blood. 88(8)

Transcription factors play an important role choreographing lineage commitment and expansion of blood cells. Nuclear factors that are expressed primarily or exclusively in hematopoietic cells are likely candidates for regulating blood cell developmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d58313213986a38052880615b68d6c7e
https://pubmed.ncbi.nlm.nih.gov/8874188

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