Zobrazeno 1 - 10
of 35
pro vyhledávání: '"G W, Gullikson"'
Autor:
Dai-Chang Yang, G. W. Gullikson, Daniel L. Flynn, Daniel P. Becker, Clara I. Villamil, Roger Nosal, Chafiq Moummi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2149-2154
A series of meso-amino(methyl)azanoradamantane benzamides has been prepared and evaluated for 5-HT4 agonism activity in the rat tunica muscularis mucosae (TMM) assay. Compound 8i is the most potent 5-HT4 agonist in the series, with an EC50 of 217 nM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23b42abbb49f0bda55dc9bbc18197fba
https://doi.org/10.1016/s0960-894x(97)00408-3
https://doi.org/10.1016/s0960-894x(97)00408-3
Publikováno v:
Alcohol. 11:389-395
Five Long-Evans hooded rats were trained to lever press according to fixed-ratio 5 reinforcement schedules for 0.06 ml dipper deliveries of 8% w/v ethanol during daily (M-F) 0.5-h experimental sessions. After ethanol self-administration was establish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa96bb075029cb4639b75303255801a
https://doi.org/10.1016/0741-8329(94)90023-x
https://doi.org/10.1016/0741-8329(94)90023-x
Autor:
Dai-Chang Yang, Roger Nosal, Daniel L. Flynn, Clara I. Villamil, Chafiq Moummi, G. W. Gullikson, Daniel P. Becker
Publikováno v:
ChemInform. 29
A series of meso-amino(methyl)azanoradamantane benzamides has been prepared and evaluated for 5-HT4 agonism activity in the rat tunica muscularis mucosae (TMM) assay. Compound 8i is the most potent 5-HT4 agonist in the series, with an EC50 of 217 nM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60106a1804efbed52b309ff774b120a9
https://doi.org/10.1002/chin.199801172
https://doi.org/10.1002/chin.199801172
Autor:
Chafiq Moummi, Dai-Chang Yang, Daniel L. Flynn, Roger Nosal, Daniel P. Becker, G. W. Gullikson, Dale P. Spangler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1613-1618
New aza(nor)adamantanes 1A , 1B , and 1C are described which exhibit properties of both 5-HT4 agonism and 5-HT3 antagonism. In particular, compound 1C [SC-52491], an azanoradamantane, exhibits an EC50 of 51 nM in a functional model of 5-HT4 agonism a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee8ca2120c6861af925b4314701bf4e8
https://doi.org/10.1016/s0960-894x(00)80441-2
https://doi.org/10.1016/s0960-894x(00)80441-2
Autor:
Daniel L. Flynn, Chafiq Moummi, Dai-Chang Yang, Daniel P. Becker, G. W. Gullikson, Clara I. Villamil
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1251-1256
A new series of cholecystokinin (CCK) antagonists are described which utilizes a new 1,3,4-trisubstituted pyrrolidinone as a scaffold for appending specific amino acid R group mimics (Figure 1). Compound 1A and 1E (SC-50998) exhibit potent nanomolar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf05097a14e72e4db52a818dfe925918
https://doi.org/10.1016/s0960-894x(00)80224-3
https://doi.org/10.1016/s0960-894x(00)80224-3
Publikováno v:
European Journal of Pharmacology. 216:47-52
Changes in mechanical events and intracellular levels of cAMP induced by the activation of the 5-HT4 receptor were investigated in the rat esophagus tunica muscularis mucosae preparation. Serotonin (5-HT) and 5 methoxytryptamine (5-MOT; 5-HT4 agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3acd529624afe4f27cca7570f8bc63
https://doi.org/10.1016/0014-2999(92)90207-k
https://doi.org/10.1016/0014-2999(92)90207-k
Autor:
Maida A. Virina, Dai-Chang Yang, Bela Goldstin, Alan E. Moormann, Daniel L. Flynn, R F Loeffler, G. W. Gullikson
Publikováno v:
Drug Development Research. 26:405-417
Zacopride is an antiemetic agent whose (S) and (R) stereoisomers demonstrate differential pharmacology at 5-HT3 receptors, emphasizing the importance of pharmacologic profiling of each enantiomer of a racemic drug mixture. Characterization of the gas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a063b29be2951d8486f7347ac9650e2c
https://doi.org/10.1002/ddr.430260404
https://doi.org/10.1002/ddr.430260404
Publikováno v:
Gastroenterology. 101:1428-1431
Cholecystokinin (CCK) receptors are currently divided into at least two subtypes: a CCK-A subtype, responsive to the sulfated form of cholecystokinin octapeptide (CCK-8) and selectively antagonized by L-364,718, and a CCK-B subtype, which shares equa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0db2cdde41f4fc998ba143598b5806c
https://doi.org/10.1016/0016-5085(91)90098-6
https://doi.org/10.1016/0016-5085(91)90098-6
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 261:G426-G432
Motility-stimulating drugs can increase gastric antral and intestinal contractions but do not usually enhance emptying unless gastroparesis is present. An alpha 2-adrenergic agonist (SC-39585A) was used to inhibit antroduodenal motility and simulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79826f763357d0432f7610d9b2cd556c
https://doi.org/10.1152/ajpgi.1991.261.3.g426
https://doi.org/10.1152/ajpgi.1991.261.3.g426
Autor:
D M, Hammerbeck, S M, McGurran, P L, Radziszewski, E A, Egging, D D, Johnson, A M, Hupperts, G W, Gullikson
Publikováno v:
Inflammation. 24(4)
Representative glucocorticosteroids (GCS) and phosphodiesterase IV (PDE4) inhibitors were compared in several models of pulmonary inflammation ranging in severity. Lung tissue eosinophil peroxidase (EPO) levels rather than bronchoalveolar lavage flui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1645c9439a93ae17a7a826369f2a234c
https://pubmed.ncbi.nlm.nih.gov/10850854
https://pubmed.ncbi.nlm.nih.gov/10850854