Zobrazeno 1 - 10 of 12 pro vyhledávání: '"G W, Danswan"'
1
Synthesis and oral antiallergic activity of carboxylic acids derived from imidazo[2,1-c][1,4]benzoxazines, imidazo[1,2-a]quinolines, imidazo[1,2-a]quinoxalines, imidazo[1,2-a]quinoxalinones, pyrrolo[1,2-a]quinoxalinones, pyrrolo[2,3-a]quinoxalinones, and imidazo[2,1-b]benzothiazoles
Autor: I R, Ager, A C, Barnes, G W, Danswan, P W, Hairsine, D P, Kay, P D, Kennewell, S S, Matharu, P, Miller, P, Robson, D A, Rowlands
Publikováno v: Journal of Medicinal Chemistry. 31:1098-1115
4H-Imidazo[2,1-c][1,4]benzoxazine-2-carboxylic acid (3) was found to possess potent activity in the IgE-induced rat passive cutaneous anaphylaxis model which may be predictive of clinical antiallergic activity. Compared to disodium cromoglycate (DSCG
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7528f763f673d8039e17911274ab6180
https://doi.org/10.1021/jm00401a009
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2
New hepato-protective agents. II. Maleopimaridyl morpholides
Autor: G W, Danswan, S, Matharu, P J, Ramm, J B, Taylor
Publikováno v: Arzneimittel-Forschung. 26(12)
A further series of derivatives of maleopimaric acid, the maleopimaridyl morpholides, has been prepared and results on their protection against galactosamine-inducted liver damage in the rat are described. The compounds (3, 4, 8 and 10) were found to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ae90f93843120372a1c356a02624ec94
https://pubmed.ncbi.nlm.nih.gov/1037272
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3
Central nervous system activity of a novel class of annelated 1,4-benzodiazepines, aminomethylene-2,4-dihydro-1H-imidazo[1,2-a][1,4]benzodiazepin-1-ones
Autor: G. W. Danswan, I. R. Ager, Peter D. Kennewell, David Kay, John B. Taylor, D. R. Harrison
Publikováno v: Journal of medicinal chemistry. 20(8)
The synthesis and CNS activity of a noval class of annelated 1,4-benzodiazepines, the aminomethylene-2,4-dihydro-1H-imidazo[1,2-a][1,4]benzodiazepines, are described. An investigation of the structure--activity relationships in the series derived fro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ece156b6abdd41cc008660d09dbb54
https://pubmed.ncbi.nlm.nih.gov/19630
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5
ChemInform Abstract: (Imidazo(1,2-a)pyrimidin-2-yl)phenylmethanones and Related Compounds as Potential Nonsedative Anxiolytics
Autor: S. Clements-Jewery, R. Murdoch, W. R. Tully, Saroop S. Matharu, Robert Westwood, G. W. Danswan, Colin R. Gardner
Publikováno v: ChemInform. 19
Several series of heterocyclic carboxylic esters were found to be active in the benzodiazepine receptor binding assay, a typical example being ethyl 7-ethyl-5-methoxyimidazo[1,2-a]quinoline-2-carboxylate (4b) with an IC50 of 150 nM. The corresponding
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd60ca0e214739f551f83f532a74466d
https://doi.org/10.1002/chin.198843201
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7
(Imidazo[1,2-a]pyrimidin-2-yl)phenylmethanones and related compounds as potential nonsedative anxiolytics
Autor: G. W. Danswan, Saroop S. Matharu, S. Clements-Jewery, W. R. Tully, Colin R. Gardner, R. Murdoch, Robert Westwood
Publikováno v: Journal of medicinal chemistry. 31(6)
Several series of heterocyclic carboxylic esters were found to be active in the benzodiazepine receptor binding assay, a typical example being ethyl 7-ethyl-5-methoxyimidazo[1,2-a]quinoline-2-carboxylate (4b) with an IC50 of 150 nM. The corresponding
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24cfb6e6a55120681600262bae2121ad
https://pubmed.ncbi.nlm.nih.gov/2897468
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8
ChemInform Abstract: CENTRAL NERVOUS SYSTEM ACTIVITY OF A NOVEL CLASS OF ANNELATED 1,4-BENZODIAZEPINES, AMINOMETHYLENE-2,4-DIHYDRO-1H-IMIDAZO(1,2-A)(1,4)BENZODIAZEPIN-1-ONES
Autor: John B. Taylor, Peter D. Kennewell, David Kay, D. R. Harrison, G. W. Danswan, I. R. Ager
Publikováno v: Chemischer Informationsdienst. 8
The synthesis and CNS activity of a noval class of annelated 1,4-benzodiazepines, the aminomethylene-2,4-dihydro-1H-imidazo[1,2-a][1,4]benzodiazepines, are described. An investigation of the structure--activity relationships in the series derived fro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::873dd3c472118f4ed26b98cbe7c78311
https://doi.org/10.1002/chin.197749268
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9
ChemInform Abstract: NEW HEPATO-PROTECTIVE AGENTS. II. MALEOPIMARIDYL MORPHOLIDES
Autor: G. W. Danswan, P. J. Ramm, John B. Taylor, S. Matharu
Publikováno v: Chemischer Informationsdienst. 8
A further series of derivatives of maleopimaric acid, the maleopimaridyl morpholides, has been prepared and results on their protection against galactosamine-inducted liver damage in the rat are described. The compounds (3, 4, 8 and 10) were found to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::225a007e504437825674d94650d21b5d
https://doi.org/10.1002/chin.197714214
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