Mechanism of hepatoprotective action of methionine and composition 'Metovitan' against a background of antituberculosis drugs administration to rats

Autor: S. I. Anisimova, G. V. Donchenko, Yu. M. Parkhomenko, V. M. Kovalenko

Publikováno v: The Ukrainian Biochemical Journal, Vol 85, Iss 2, Pp 59-67 (2013)

Oral administration of antituberculosis drugs to rats for 60 days in doses that are equivalent to clinical ones, causes changes in mRNA levels expression of liver cytochrome P-450 isoforms CYP3A2, CYP2C23, CYP2E1 and pro- and antioxidant state. Exper

Externí odkaz: https://doaj.org/article/9c3a87bdc8634e11bf6a0d3cc4b23310

METOVITAN PREVENTS THE ACCUMULATION OF THIAMINE DIPHOSPHATE OXIDIZED FORM IN RAT TISSUES UNDER IRRADIATION

Autor: G. V. Donchenko, E. N. Gorban, O. A. Mejenskaya, L. I. Chehovskaya, S. P. Stepanenko, Yu. M. Parkhomenko

Publikováno v: Biotechnologia Acta, Vol 8, Iss 4, Pp 63-70 (2015)

The aim of the research was to test the ability of the drug "Metovitan" to prevent the redox balance disturbance in the tissues and thiamine diphosphate irreversible oxidation upon exposure of ionizing radiation on the body. The rats were subjected t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ca5f144ff34e2ad493605baaef61e5
http://biotechnology.kiev.ua/images/stories/no4_2015/parkhomenko_4_2015.pdf

Effect of complexes of precursors and modulators of coenzyme q biosynthesis on functional state of old rats' heart mitochondria

Autor: N. A. Strutynskaya, G. L. Vavilova, Vadim F. Sagach, L. S. Mkhitaryan, S. V. Tymoshchuk, E. B. Kuchmenko, D. N. Petukhov, G. V. Donchenko

Publikováno v: Biomeditsinskaya Khimiya. 56:244-256

Our research demonstrate that ageing leads to changes in activity of electron-transporting enzyme complexes in myocardial mitochondria of old rats and to increased sensitivity of mitochondrial permeability transition pore to inductors of its opening

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ace6027d3c894103f25aaf125a9bcb6
https://doi.org/10.18097/pbmc20105602244

Metovitan prevents accumulation of thiamin diphosphate oxygenized form in rat tissues under irradiation

Autor: Yu. M. Parkhomenko, G. V. Donchenko, L. I. Chehovskaya, S. P. Stepanenko, O. A. Mejenskaya, E. N. Gorban

Publikováno v: Biotechnologia Acta.

The aim of the research was to test the ability of the drug “Metovitan” to prevent the redox balance disturbance in the tissues and thiamine diphosphate irreversible oxidation upon exposure of ionizing radiation on the body. The rats were undergo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2806::cb87fdf11af0de33a22db1aad6943d87
http://cyberleninka.ru/article_covers/16051773.png

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Publikováno v: Journal of Biosciences. 24:33-198

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9b84c9ab166d1a516f4d6763270d4b5
https://doi.org/10.1007/bf02989373