Zobrazeno 1 - 10
of 65
pro vyhledávání: '"G T Stevenson"'
Publikováno v:
The Journal of Immunology. 158:2242-2250
We describe a method for linking human normal Fc gamma1, via stable thioether bonds emerging from its hinge, to any molecule expressing a free sulfhydryl (SH) group. The Fc hinge may be closed by a disulfide (SS) bond or left open. Preparation begins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f8c02fb3788810c7dc5d398b634a2e8
https://doi.org/10.4049/jimmunol.158.5.2242
https://doi.org/10.4049/jimmunol.158.5.2242
Publikováno v:
Clinical and Experimental Immunology. 107:364-371
SUMMARY Immunotherapy using MoAbs is inefficient due to limited activation of human effectors by mouse antibodies and multiple protective mechanisms available to host cells against autologous complement. We have used chemically engineered antibody co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced7ac8cfacdf4d8661a1d7fd0b056e7
https://doi.org/10.1111/j.1365-2249.1997.265-ce1156.x
https://doi.org/10.1111/j.1365-2249.1997.265-ce1156.x
Publikováno v:
The Journal of Immunology. 155:925-937
Multiple myeloma is a malignancy of plasma cells for which there is no effective treatment. To develop an immunotherapeutic agent, we have raised a high affinity mAb (AT13/5) against CD38, one of the few well-characterized surface Ags present on myel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44b26ebc42b31b8c2accab75df55a0ea
https://doi.org/10.4049/jimmunol.155.2.925
https://doi.org/10.4049/jimmunol.155.2.925
Publikováno v:
Cancer Immunology Immunotherapy. 36:149-155
Apoptosis in three lymphoma cell lines has been studied following cytotoxicity induced in vitro by normal human blood lymphocytes utilizing either natural killer (NK) or antibody-dependent cellular cytotoxic (ADCC) mechanisms. Guinea-pig L2C leukaemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b87e18cc8e6f66390bd2293efded33
https://doi.org/10.1007/bf01741085
https://doi.org/10.1007/bf01741085
Publikováno v:
Scandinavian Journal of Immunology. 36:221-231
Changes in the intracellular calcium ion concentration ([Ca2+]i) of monocytes, granulocytes, and NK cells have been studied following either (1) independent cross-linking of Fc gamma receptors (Fc gamma R) I, II, or III, with F(ab gamma')2 fragments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73aff0e66c0314ce61aecb0218339e64
https://doi.org/10.1111/j.1365-3083.1992.tb03094.x
https://doi.org/10.1111/j.1365-3083.1992.tb03094.x
Publikováno v:
The Journal of Immunology. 147:60-69
To investigate whether the retargeting of resting CTL can benefit from cooperative signaling between the TCR/CD3 complex and various accessory molecules, such as CD2, CD4, CD5, and CD8, we have constructed a series of trispecific F(ab')3 derivatives.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3adfb942a6fe31b6a3bd3f8a2c901314
https://doi.org/10.4049/jimmunol.147.1.60
https://doi.org/10.4049/jimmunol.147.1.60
Publikováno v:
The Journal of Immunology. 146:2461-2468
We have investigated the antigenic modulation induced by a number of antibody fragments and derivatives directed against the idiotype of the surface Ig of the L2C guinea pig B lymphoblastic leukemia, and studied the effects upon such modulation of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfc4d4dbbc1c2d5854a2a43b1920b89b
https://doi.org/10.4049/jimmunol.146.7.2461
https://doi.org/10.4049/jimmunol.146.7.2461
Publikováno v:
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. 159
One approach to improving the results of antibody treatment of posttransplant and other lymphomas is to alter the geometry of the antibody molecule so as to enhance its cytotoxicity. When antibody alights on a cell, cytotoxicity can be exerted by ini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6bb6b5d0f63ca7929d32e52b978b4ab5
https://pubmed.ncbi.nlm.nih.gov/11785834
https://pubmed.ncbi.nlm.nih.gov/11785834
Autor:
J. Y. Blay, G. T. Stevenson, Noel-Jean Milpied, Veronique Leblond, N. Blanc-Brunat, Jean Louis Touraine, Jeanne L. Garnier
Publikováno v:
Immunosurveillance, Immunodeficiencies and Lymphoproliferations ISBN: 9783642626760
The treatment of post-transplant lymphomas still needs major improvements in order to put the patient in remission and to retain graft function. Chemotherapy is far too toxic in these patients. A more specific treatment such as anti-B-cell monoclonal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::187ec4cb2a7916dc442b312090cd254e
https://doi.org/10.1007/978-3-642-56352-2_14
https://doi.org/10.1007/978-3-642-56352-2_14
Publikováno v:
Immunosurveillance, Immunodeficiencies and Lymphoproliferations ISBN: 9783642626760
One approach to improving the results of antibody treatment of posttransplant and other lymphomas is to alter the geometry of the antibody molecule so as to enhance its cytotoxicity. When antibody alights on a cell, cytotoxicity can be exerted by ini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffc61d554c3f906ca4c7ceb3e4b728fa
https://doi.org/10.1007/978-3-642-56352-2_13
https://doi.org/10.1007/978-3-642-56352-2_13