Výsledky vyhledávání - "G T G Swayne"

Identification of ethanolamine in rat and gerbil brain tissue extracts by NMR spectroscopy

Autor: A G Swanson, Steven Williams, G B Fox, J B Clark, K L Allen, K.D. Sales, S C Smart, G T G Swayne, M J Newman

Publikováno v: NMR in Biomedicine. 7:356-365

Some NMR resonances which have previously been observed but not identified in mammalian brain tissue extracts have been shown to arise from ethanolamine. This conclusion is drawn from a systematic study of the perchloric acid extracts of rodent brain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723780d7b96853f785ffd7cb37d96fce
https://doi.org/10.1002/nbm.1940070806

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Design and synthesis of a series of combined vasodilator-.beta.-adrenoceptor antagonists based on 6-arylpyridazinones

Autor: E. M. Taylor, G. T. G. Swayne, W. Howson, D. R. Reavill, R. A. Slater

Publikováno v: Journal of Medicinal Chemistry. 31:345-351

A series of new 6-[4-[[(aryloxy)acyl]amino]phenyl]-4,5-dihydropyridazinones have been synthesized and evaluated as combined vasodilator/beta-adrenoceptor antagonists and potential antihypertensive agents. Many of the early compounds displayed an unac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e80694f906a56edfd2b08e71906a302
https://doi.org/10.1021/jm00397a013

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Synthesis and biological activity of the four stereoisomers of 6-[4-[3-[[2-hydroxy-3-[4-[2- (cyclopropylmethoxy)ethyl]phenoxy]propyl]amino]-propionamido] phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone, a combined vasodilator and beta-adrenoceptor antagonist

Autor: M. B. Mitchell, J. Kitteringham, G. T. G. Swayne, J. Mistry, R. Novelli, W. Howson, R. A. Slater

Publikováno v: Journal of medicinal chemistry. 31(2)

6-[4-[3-[[2-Hydroxy-3-[4-[2- (cyclopropylmethoxy)ethyl]phenoxy]propyl]amino]propionamido] phenyl]- 5-methyl-4,5-dihydro-3(2H)-pyridazinone (3) consists of a mixture of four stereoisomers, i.e., two racemates, as a consequence of the two asymmetric ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0973114b4b2161189a27e4e2742b4d0d
https://pubmed.ncbi.nlm.nih.gov/2892935

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