Výsledky vyhledávání

Exploratory comparison of vaginal glycogen and Lactobacillus levels in premenopausal and postmenopausal women

Autor: Paria Mirmonsef, Douglas Gilbert, Sharada P. Modur, Alan L. Landay, Kerrie L. McCotter, Elizabeth T. Golub, Audrey L. French, G T Spear, Derick Burgad

Publikováno v: Menopause. 22:702-709

OBJECTIVE Previous studies have suggested that glycogen expression in the vaginal epithelium decreases during menopause, resulting in reduced levels of lactobacilli. However, free glycogen in genital fluids and its relationship with Lactobacillus lev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d20ec85045b36118ffc389937abdb0
https://doi.org/10.1097/gme.0000000000000397

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Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to Toll-like receptor 4 and Toll-like receptor 2 ligands via soluble CD14

Autor: Anjali Nair, Charles A. Bush-Joseph, Carla R. Scanzello, Veero Kanda, Anne-Marie Malfait, Nikhil N. Verma, Mary K. Crow, Alison Finnegan, Susan Chubinskaya, Katalin Mikecz, G T Spear, Tibor T. Glant

Publikováno v: Arthritis & Rheumatism. 64:2268-2277

Synovial inflammation, a feature of both osteoarthritis (OA) and meniscal injury, is hypothesized to be triggered in part via stimulation of Toll-like receptors (TLRs). We undertook this study to test whether a TLR-2- or TLR-4-stimulating factor in s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b05551162957132356046fa2a7835cf
https://doi.org/10.1002/art.34495

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Short-Chain Fatty Acids Induce Pro-Inflammatory Cytokine Production Alone and in Combination with Toll-Like Receptor Ligands

Autor: Alan L. Landay, Douglas Gilbert, Paria Mirmonsef, G T Spear, Mohammad R. Zariffard, Hadijat Makinde

Publikováno v: American Journal of Reproductive Immunology. 67:391-400

Problem Short chain fatty acids (SCFAs), produced at relatively high levels by anaerobic bacteria in bacterial vaginosis (BV), are believed to be anti-inflammatory. BV, a common alteration of the genital microbiota associated with increased susceptib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b080f87216d22cdb60e8a13c2f426e7f
https://doi.org/10.1111/j.1600-0897.2011.01089.x

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The Effects of Commensal Bacteria on Innate Immune Responses in the Female Genital Tract

Autor: Paria Mirmonsef, Alan L. Landay, G T Spear, Amandeep Kaur, Mohammad R. Zariffard, Douglas Gilbert, Bruce R. Hamaker

Publikováno v: American Journal of Reproductive Immunology. 65:190-195

Citation Mirmonsef P, Gilbert D, Zariffard MR, Hamaker BR, Kaur A, Landay AL, Spear GT. The effects of commensal bacteria on innate immune responses in the female genital tract. Am J Reprod Immunol 2011; 65: 190–195 The innate and adaptive immune s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb2c664dbacb44d8b84ad12a25457955
https://doi.org/10.1111/j.1600-0897.2010.00943.x

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Characterization of IL-22 and IL-17 Expressing Leukocytes in the Cervix

Autor: Jeff Martinson, G T Spear, Hadijat Makinde, Alan L. Landay, Jill Plants, Pincas Bitterman, Nell S. Lurain

Publikováno v: American journal of reproductive immunology (New York, N.Y. : 1989). 75(1)

Problem Identification of the types of cells that produce IL-17 and IL-22 in the genital tract can clarify the roles that these cytokines play in responses to pathogens. Method of study We isolated and stimulated cells from cervical tissue to identif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94638e2b6fab64d290fd08123de89e7a
https://pubmed.ncbi.nlm.nih.gov/26459205

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Effect of pH on Cleavage of Glycogen by Vaginal Enzymes

Autor: Byung-Hoo Lee, Mary McKenna, Bruce R. Hamaker, Hadijat Makinde, G T Spear, Audrey L. French, Alan L. Landay

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0132646 (2015)
PLoS ONE

Glycogen expressed by the lower genital tract epithelium is believed to support Lactobacillus growth in vivo, although most genital isolates of Lactobacillus are not able to use glycogen as an energy source in vitro. We recently reported that α-amyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f6a384e312a5f9849ed08037321768
http://europepmc.org/articles/PMC4501710?pdf=render

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The vaginal microbiota over an 8- to 10-year period in a cohort of HIV-infected and HIV-uninfected women

Autor: Supriya D. Mehta, Jacques Ravel, Pawel Gajer, Kathleen M. Weber, G T Spear, Derick Burgad, Brock Donovan, Mardge H. Cohen, Douglas Gilbert

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 2, p e0116894 (2015)

Background We identified predominant vaginal microbiota communities, changes over time, and how this varied by HIV status and other factors in a cohort of 64 women. Methods Bacterial DNA was extracted from reposited cervicovaginal lavage samples coll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb5ed37bf4655de85c20e354fa4216b
https://pubmed.ncbi.nlm.nih.gov/25675346

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Characterization of Viral Dynamics in Human Immunodeficiency Virus Type 1–Infected Patients Treated with Combination Antiretroviral Therapy: Relationships to Host Factors, Cellular Restoration, and Virologic End Points

Autor: Elizabeth Connick, Alan L. Landay, Hulin Wu, Margo Heath-Chiozzi, John M. Leonard, Lawrence Fox, Franck Rousseau, Harold A. Kessler, Daniel McClernon, John Spritzler, Daniel R. Kuritzkes, Michael M. Lederman, G T Spear

Publikováno v: The Journal of Infectious Diseases. 179:799-807

Biphasic plasma viral decays were modeled in 48 patients treated with ritonavir, zidovudine, and lamivudine. Estimated first- and second-phase decay rates were d 1 as 0.47/day and d 2 as 0.04/day. Interpatient differences in both decay rates were sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1775da7ecfc8864618bb6b45467e76
https://doi.org/10.1086/314670

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B lymphocytes in lymph nodes and peripheral blood are important for binding immune complexes containing HIV‐1

Autor: Mohammed Saifuddin, D M Takefman, G T Spear, J J Jakubik

Publikováno v: Immunology. 96:612-619

We investigated the interaction of HIV immune complexes (HIV IC) with mononuclear cells from lymph nodes and blood. While antibody alone did not affect binding of HIV IC to mononuclear cells, antibody plus complement increased binding by as much as 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917d51e023aa094b4dbd91896d9c12d8
https://doi.org/10.1046/j.1365-2567.1999.00304.x

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