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P380 Changes in faecal microbiome and metabolome are more pronounced in Crohn’s disease patients who adhered to the CD-TREAT diet and responded by calprotectin

Autor: V Svolos, R Hansen, R K Russell, D R Gaya, J P Seenan, J Macdonald, D Wilson, P Henderson, S Din, G T Ho, C Quince, U Z Ijaz, S Milling, B Nichols, R Papadopoulou, S McKirdy, L Gervais, S Shields, K Gerasimidis

Publikováno v: Journal of Crohn's and Colitis. 17:i513-i515

Background Treatment with the CD-TREAT solid food diet improves disease activity indices, faecal calprotectin (FCAL) levels and quality of life in adults and children with active Crohn’s disease (CD); particularly in patients who adhere to the diet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eab0b656c79bc9f17acb1d6efb9b9ef4
https://doi.org/10.1093/ecco-jcc/jjac190.0510

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DOP28 Aconitate decarboxylase 1 (ACOD1) represents a crucial regulator of monocyte recruitment, survival and proinflammatory status in intestinal inflammation

Autor: G R Jones, L Hegarty, W T'Jonck, C Adams, B Drury, A Byrne, G T Ho, C Bain

Publikováno v: Journal of Crohn's and Colitis. 17:i93-i94

Background Aconitate decarboxylase 1 (ACOD1; also known as IRG-1) is the ubiquitous source of itaconate, which dampens inflammasome activation by preventing HIF1a production of IL-1b and prevents TNF production through NRF2 activation. We reasoned th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3842d38669eafabe7d1a4276429b036
https://doi.org/10.1093/ecco-jcc/jjac190.0068

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P328 Holistic well-being as Patient-reported outcomes (PROs) in translational IBD research: Prospective capture of CUCQ32 as study endpoints for mechanistic biomarker MUSIC/GIDAMPs study

Autor: R Hall, C S Chuah, E Brownson, B Poulose, O Athena, C Mowat, J Macdonald, J P Seenan, G T Ho

Publikováno v: Journal of Crohn's and Colitis. 17:i467-i467

Background There is increasing recognition of ‘holistic’ wellbeing as a key target in the management of IBD. Patient-reported outcomes (PROs) capture the impact of IBD on social, emotional and general wellbeing. Recently, regulatory bodies such a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc954bfe3e32c3ffed80d7548dcbbf0c
https://doi.org/10.1093/ecco-jcc/jjac190.0458

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DOP68 CD-TREAT diet induces remission and improves quality of life in an open label trial in children and adults with active Crohn’s Disease

Autor: V Svolos, R Hansen, R Russell, D R Gaya, S John Paul, J Macdonald, B Nichols, R Papadopoulou, M Logan, S Mckirdy, R Gervais, U Ijaz, S Milling, S Shields, D Wilson, P Henderson, S Din, G T Ho, K Gerasimidis

Publikováno v: Journal of Crohn's and Colitis. 16:i112-i112

Background Exclusive enteral nutrition (EEN) is an established induction treatment for active Crohn’s disease (CD) with a proposed mechanism of action involving the gut microbiome. We have previously shown that CD-TREAT diet, a food-based diet with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97d9257d266d68b29f731dfd189dc177
https://doi.org/10.1093/ecco-jcc/jjab232.107

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