Zobrazeno 1 - 10
of 31
pro vyhledávání: '"G T, De Sanctis"'
Publikováno v:
Clinical & Experimental Allergy. 29:37-47
Human asthma is characterized by three critical phenotypic traits: intermittent reversible airway obstruction, airway hyperresponsiveness and airway inflammation. In animal models of asthma, airway hyperresponsiveness is an important feature. This tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94f1b3884e53e0ff5937908110b812e2
https://doi.org/10.1046/j.1365-2222.1999.00007.x
https://doi.org/10.1046/j.1365-2222.1999.00007.x
Publikováno v:
Annual Review of Physiology. 61:593-625
▪ Abstract The mouse is an ideal species for investigation at the interface of lung biology and lung function. As detailed in this review, there are well-developed methods for the quantitative study of lung function in mice. These methods can be ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ba7469ad3629b0dea82a74d0e5fba6
https://doi.org/10.1146/annurev.physiol.61.1.593
https://doi.org/10.1146/annurev.physiol.61.1.593
Autor:
G. T. De Sanctis, Lester Kobzik, S J Krinzman, Mohamed H. Sayegh, Carolyn E. Donovan, David L. Perkins, D A Mark, Peter S. Linsley, James A. Lederer, Patricia W. Finn
Publikováno v:
International Immunology. 10:1647-1655
We examined the roles of CD80 (B7-1) and CD86 (B7-2) in a model of allergic pulmonary inflammation and airway hyper-responsiveness (AHR) by selectively inhibiting either CD80 or CD86. Inhibition of co-stimulation by either CD80 or CD86 affected multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0916b7d10a5535baddb6cabbf5ce688
https://doi.org/10.1093/intimm/10.11.1647
https://doi.org/10.1093/intimm/10.11.1647
Autor:
O. Radmark, Tucker Collins, Jing Du, Eric S. Silverman, G. T. De Sanctis, Jeffrey M. Drazen, B. Samuelsson
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 19:316-323
5-Lipoxygenase (5-LO), an enzyme essential for the formation of leukotrienes, is functionally modulated by a number of mechanisms, including transcriptional controls. The 5-LO promoter has a unique G+C-rich sequence, located between 176 and 147 base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635e77c93299ccd8a4da5f78b2a4a0ca
https://doi.org/10.1165/ajrcmb.19.2.3154
https://doi.org/10.1165/ajrcmb.19.2.3154
Autor:
A. Karkhanis, S. G. Bjarnason, G. T. De Sanctis, Francis H. Y. Green, X. Jiang, Sheldon H. Roth, T. Feroah
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 54:261-283
This study reports experiments designed to evaluate the dose and temporal effects of an atmospheric pollutant, sulfuric acid (H 2 SO 4 ) aerosol, on the dynamic components of the respiratory cycle. Ventilation was measured in a whole-body barometric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf6554779b4a4018b81ef0dd07c1c125
https://doi.org/10.1080/009841098158845
https://doi.org/10.1080/009841098158845
Autor:
J J Murray, John D. Kemp, K. Asano, A Pillari, Edwin K. Silverman, Dennis K. Ledford, Patricia W. Finn, K Serino, Jeffrey M. Drazen, Elliot Israel, Eric S. Silverman, Tucker Collins, J Grobholz, G. T. De Sanctis, D Tinkleman, Andre Fischer, W Busse, David R. Beier, Kwang Ho In, P Rubin, Chandri N. Yandava, Song-Jung Kim, Anthony W. Segal, T P Keith
Publikováno v:
Journal of Clinical Investigation. 99:1130-1137
Five lipoxygenase (5-LO) is the first committed enzyme in the metabolic pathway leading to the synthesis of the leukotrienes. We examined genomic DNA isolated from 25 normal subjects and 31 patients with asthma (6 of whom had aspirin-sensitive asthma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff1a171e0ccaf829bdc8bf492f4995e
https://doi.org/10.1172/jci119241
https://doi.org/10.1172/jci119241
Autor:
G. T. De Sanctis, Jeffrey M. Drazen
Publikováno v:
Research in Immunology. 148:73-79
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf01aa66c0b448918bd936381a8a1100
https://doi.org/10.1016/s0923-2494(97)86276-1
https://doi.org/10.1016/s0923-2494(97)86276-1
Autor:
Yi Wang, David A. Mark, James A. Listman, David C. Christiani, David L. Perkins, Patricia W. Finn, Carolyn E. Donovan, Manuela Cernadas, S J Krinzman, I Katona, K Nassr, Lester Kobzik, G. T. De Sanctis
Publikováno v:
Journal of Clinical Investigation. 98:2693-2699
Activation of naive T cells requires at least two signals. In addition to the well characterized interaction of the T cell antigen receptor with the antigen/MHC expressed on an antigen-presenting cell, T cell activation also requires costimulation by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18d433d4fd7d37b97dcf13d9aff56de
https://doi.org/10.1172/jci119093
https://doi.org/10.1172/jci119093
Autor:
P. Maes, Ernst M. App, M. Coffiner, Bruce K. Rubin, R. P. Tomkiewicz, G. T. De Sanctis, Malcolm King
Publikováno v:
Pulmonary Pharmacology. 8:259-265
A newly synthesized mucolytic agent, N-acetylcysteine L-lysinate (Nacystelyn) was studied. Tracheal mucus velocity (TMV), transepithelial potential difference (PD), rheological properties, and ion content of collected airway secretions were evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d58285150b962ce45203cb8277f2390
https://doi.org/10.1006/pulp.1995.1035
https://doi.org/10.1006/pulp.1995.1035
Publikováno v:
Scopus-Elsevier
This study reports experiments designed to evaluate the role of neurokinin-1 (NK1) receptors for substance P (SP) in the ventilatory response to acute hypoxia. Ventilation was measured by indirect plethysmography in eight unanesthetized unrestrained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b5148e9106e47d6400f8f8dcfad85c
https://doi.org/10.1152/jappl.1994.76.4.1528
https://doi.org/10.1152/jappl.1994.76.4.1528