Zobrazeno 1 - 10 of 159 pro vyhledávání: '"G Summerfield"'
1
The GSK Bioanalytical Hub model in bioanalysis: maximizing the synergies of co-locating various platforms in support of regulated and nonregulated study end points
Autor: Scott G Summerfield, Huaping Tang, Vilma Decman, Lee Abberley, George Gunn, Eric Yang
Publikováno v: Bioanalysis. 15:127-132
The term “bioanalytical” encompasses a much greater breadth of analytical deliverables than ever before. Circulating drug concentration data are complemented by experimental evidence of drug in biophase, immunogenicity, target engagement and subs
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3dbc32c54fbfc5304b8fa15ef8fee559
https://doi.org/10.4155/bio-2022-0180
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3
2020 White Paper on Recent Issues in Bioanalysis: BMV of Hybrid Assays, Acoustic MS, HRMS, Data Integrity, Endogenous Compounds, Microsampling and Microbiome (Part 1 – Recommendations on Industry/Regulators Consensus on BMV of Biotherapeutics by LCMS, Advanced Application in Hybrid Assays, Regulatory Challenges in Mass Spec, Innovation in Small Molecules, Peptides and Oligos)
Autor: Luca Ferrari, Wenkui Li, Christopher P. Evans, Lieve Dillen, Noah Post, Jens Sydor, Jinhui Zhang, Susan Stojdl, Boris Gorovits, Jason Boer, Anita Lee, Mark G. Qian, Natasha Savoie, Kevin P. Bateman, Brian Dean, Allena J. Ji, Jiang Wu, Amanda Wilson, Michael H. Buonarati, Jian Wang, Gustavo Mendes Lima Santos, Daniel S Spellman, Hendrik Neubert, Hui Zhang, Scott G. Summerfield, Eric Yang, Nilufer Tampal, Parya Nouri, Christopher J Beaver, Anna Edmison, Christine Fandozzi, Troy Voelker, Jenny Zhang, Fabio Garofolo, Michael McGuinness, Sam Haidar, Bill Mylott, Stephen Vinter, Arindam Dasgupta, Patrick Faustino, Daniela Fraier, Wenying Jian, Tahseen Mirza, Sune Sporring, Diaa Shakleya, Timothy V Olah, Eric Woolf, Stephen C. Alley, Nicola Hughes, Suman Dandamudi, Hongbin Yu, Phillip Sundman, Rebecca Elliott, Lina Luo, Jan Welink
Publikováno v: Bioanalysis. 13:203-238
The 14th edition of the Workshop on Recent Issues in Bioanalysis (14th WRIB) was held virtually on June 15–29, 2020 with an attendance of over 1000 representatives from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d0f1046448eff2611c3c8337e268531
https://doi.org/10.4155/bio-2020-0324
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5
Free Drug Theory - No Longer Just a Hypothesis?
Autor: Scott G, Summerfield, James W T, Yates, David A, Fairman
Publikováno v: Pharmaceutical research. 39(2)
The Free Drug Hypothesis is a well-established concept within the scientific lexicon pervading many areas of Drug Discovery and Development, and yet it is poorly defined by virtue of many variations appearing in the literature. Clearly, unbound drug
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::395e858f0366e1d16b7219d405877d61
https://pubmed.ncbi.nlm.nih.gov/35112229
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6
Incurred sample reanalysis at GSK: what have we learned?
Autor: Matthew Barfield, Stephen White, Scott G. Summerfield
Publikováno v: Bioanalysis. 10:1755-1766
Outcomes of incurred sample reanalysis (ISR) studies have been reviewed from a decade of internally supported bioanalysis. From over 1000 bioanalytical pharmacokinetic end points, 26 bioanalytical studies have failed against predefined ISR acceptance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9666512bd3866d83b5559c6738515ac3
https://doi.org/10.4155/bio-2018-0204
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8
2018 White Paper on Recent Issues in Bioanalysis: ‘A global bioanalytical community perspective on last decade of incurred samples reanalysis (ISR)’ (Part 1 – small molecule regulated bioanalysis, small molecule biomarkers, peptides & oligonucleotide bioanalysis)
Autor: Charles S Hottenstein, Seongeun Julia Cho, Dina Goykhman, Daniela Verthelyi, Jens Sydor, Natasha Savoie, Steven P. Piccoli, Stephanie Fraser, Alex Bulychev, Elana Cherry, Yan Zhang, Anna Edmison, Ingo Röhl, Daniela Fraier, Lieve Dillen, Fabio Garofolo, Yoshiro Saito, Michael H. Buonarati, Adrien Musuku, Timothy Sangster, Barry R Jones, Eric Yang, Ragu Ramanathan, Tate Owen, Nico C van de Merbel, Anton I. Rosenbaum, Christopher Stebbins, Allena J. Ji, Daniel A. Norris, Akiko Ishii-Watabe, Rachel Green, Sean Kassim, Emma Whale, Amanda Wilson, Lina Luo, Neil Henderson, Christopher A. James, Sam Haidar, Alexander Behling, Nicola Hughes, Yuanxin Xu, Scott G. Summerfield, Isabelle Cludts, Stephen Vinter, Tom Verhaeghe, Gustavo Mendes Lima Santos, Robert Dodge, Eric Woolf, Mark Ma, Jan Welink, Kirk Brown, Uma Kavita, Hyun Gyung Jang
Publikováno v: Bioanalysis. 10:1781-1801
The 2018 12th Workshop on Recent Issues in Bioanalysis (12th WRIB) took place in Philadelphia, PA, USA on April 9–13, 2018 with an attendance of over 900 representatives from pharmaceutical/biopharmaceutical companies, biotechnology companies, cont
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8d073b6bbc20524afacbc35eb80548f
https://doi.org/10.4155/bio-2018-0268
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9
Drug Distribution into Peripheral Nerve
Autor: Xiaohong Yu, Zehong Wan, Xueying Sun, Wei Zhen, Xiaoyan Zhu, Liang Huang, Houfu Liu, Tingting Fu, Wandong Zhang, Gang Lu, Ting Yang, Shengqian Wu, Jihong Liu, Scott G. Summerfield, Jianfei Wang, Wei Cai, Georg C. Terstappen, Kelly Dong, Yan Chen
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 365:336-345
Little is known about the impact of the blood-nerve barrier (BNB) on drug distribution into peripheral nerves. In this study, we examined the peripheral nerve penetration in rats of 11 small-molecule drugs possessing diverse physicochemical and trans
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb048f2a348c20af195813afc2bdd370
https://doi.org/10.1124/jpet.117.245613
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