Zobrazeno 1 - 10
of 134
pro vyhledávání: '"G Steven, Bova"'
Autor:
Anssi Nurminen, Serafiina Jaatinen, Sinja Taavitsainen, Gunilla Högnäs, Tom Lesluyes, Naser Ansari-Pour, Teemu Tolonen, Kerstin Haase, Antti Koskenalho, Matti Kankainen, Juho Jasu, Hanna Rauhala, Jenni Kesäniemi, Tiia Nikupaavola, Paula Kujala, Irina Rinta-Kiikka, Jarno Riikonen, Antti Kaipia, Teemu Murtola, Teuvo L. Tammela, Tapio Visakorpi, Matti Nykter, David C. Wedge, Peter Van Loo, G. Steven Bova
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-15 (2023)
Abstract Background Prostate cancer (PrCa) genomic heterogeneity causes resistance to therapies such as androgen deprivation. Such heterogeneity can be deciphered in the context of evolutionary principles, but current clinical trials do not include e
Externí odkaz:
https://doaj.org/article/7808b5d0d78d41449b9f048d30c6fc39
Autor:
Heidi Kaljunen, Sinja Taavitsainen, Roosa Kaarijärvi, Eerika Takala, Ville Paakinaho, Matti Nykter, G. Steven Bova, Kirsi Ketola
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Prostate cancer is one of the leading causes of death among men worldwide, and thus, research on the genetic factors enabling the formation of treatment-resistant cancer cells is crucial for improving patient outcomes. Here, we report a cell line-spe
Externí odkaz:
https://doaj.org/article/fcb620ee0a1c4bc09ed5bc03a27105a7
Autor:
Claudia Buhigas, Anne Y. Warren, Wing-Kit Leung, Hayley C. Whitaker, Hayley J. Luxton, Steve Hawkins, Jonathan Kay, Adam Butler, Yaobo Xu, Dan J. Woodcock, Sue Merson, Fiona M. Frame, Atef Sahli, Federico Abascal, CRUK-ICGC Prostate Cancer Group, Iñigo Martincorena, G. Steven Bova, Christopher S. Foster, Peter Campbell, Norman J. Maitland, David E. Neal, Charlie E. Massie, Andy G. Lynch, Rosalind A. Eeles, Colin S. Cooper, David C. Wedge, Daniel S. Brewer
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-16 (2022)
Abstract Background Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present in the normal prostate predisposing to cancer development. In the present study we applied W
Externí odkaz:
https://doaj.org/article/ab88a2ce376d486096a3008701e9592f
Autor:
Qing Kay Li, Jing Chen, Yingwei Hu, Naseruddin Höti, Tung-Shing Mamie Lih, Stefani N. Thomas, Li Chen, Sujayita Roy, Alan Meeker, Punit Shah, Lijun Chen, G. Steven Bova, Bai Zhang, Hui Zhang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Prostate cancer (PCa) is a heterogeneous group of tumors with variable clinical courses. In order to improve patient outcomes, it is critical to clinically separate aggressive PCa (AG) from non-aggressive PCa (NAG). Although recent genomic s
Externí odkaz:
https://doaj.org/article/eec67f5b900a4b039dc046a5f2d3d03b
Autor:
Juho Jasu, Teemu Tolonen, Emmanuel S. Antonarakis, Himisha Beltran, Susan Halabi, Mario A. Eisenberger, Michael A. Carducci, Yohann Loriot, Kim Van der Eecken, Martijn Lolkema, Charles J. Ryan, Sinja Taavitsainen, Silke Gillessen, Gunilla Högnäs, Timo Talvitie, Robert J. Taylor, Antti Koskenalho, Piet Ost, Teemu J. Murtola, Irina Rinta-Kiikka, Teuvo Tammela, Anssi Auvinen, Paula Kujala, Thomas J. Smith, Pirkko-Liisa Kellokumpu-Lehtinen, William B. Isaacs, Matti Nykter, Juha Kesseli, G. Steven Bova
Publikováno v:
European Urology Open Science, Vol 30, Iss , Pp 47-62 (2021)
Background: Systematic identification of data essential for outcome prediction in metastatic prostate cancer (mPC) would accelerate development of precision oncology. Objective: To identify novel phenotypes and features associated with mPC outcome, a
Externí odkaz:
https://doaj.org/article/11491b30f8294e5aade6fdfb5c1a7835
Autor:
Mina Sattari, Annika Kohvakka, Elaheh Moradi, Hanna Rauhala, Henna Urhonen, William B Isaacs, Matti Nykter, Teemu J Murtola, Teuvo L. J. Tammela, Leena Latonen, G. Steven Bova, Juha Kesseli, Tapio Visakorpi
Publikováno v:
Endocrine-Related Cancer.
Prostate cancer (PCa) is the second-most common cause of male cancer-related death in western industrialized countries, and the emergence of metastases is a key challenge in the treatment of PCa. Accumulating studies have shown that long noncoding RN
Autor:
Barry D. Nelkin, Douglas W. Ball, John T. Isaacs, G. Steven Bova, Eric K. Nakakura, Jong-In Park, Christopher J. Strock
Supplementary Movie 2 from Cyclin-Dependent Kinase 5 Activity Controls Cell Motility and Metastatic Potential of Prostate Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df65262f92c666e6571f2deceb7beb4
https://doi.org/10.1158/0008-5472.22364846
https://doi.org/10.1158/0008-5472.22364846
Supplementary Table 1, Figures 1-8 from Intragenic Rearrangement and Altered RNA Splicing of the Androgen Receptor in a Cell-Based Model of Prostate Cancer Progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e0ad4572c08593a7c467a3e56422e7
https://doi.org/10.1158/0008-5472.22387181.v1
https://doi.org/10.1158/0008-5472.22387181.v1
Autor:
William G. Nelson, Angelo M. De Marzo, G. Steven Bova, William B. Isaacs, Theodore L. DeWeese, Jessica Hicks, James Morgan, Rafael A. Irizarry, Zhijin Wu, Toby C. Cornish, Bora Gurel, Yonggang Zhang, Michael C. Haffner, Srinivasan Yegnasubramanian
Supplementary Figures 4-8 from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328daa676963714c0aca50e166c6a0f0
https://doi.org/10.1158/0008-5472.22374315
https://doi.org/10.1158/0008-5472.22374315
Autor:
William G. Nelson, Angelo M. De Marzo, G. Steven Bova, William B. Isaacs, Theodore L. DeWeese, Jessica Hicks, James Morgan, Rafael A. Irizarry, Zhijin Wu, Toby C. Cornish, Bora Gurel, Yonggang Zhang, Michael C. Haffner, Srinivasan Yegnasubramanian
Hypomethylation of CpG dinucleotides in genomic DNA was one of the first somatic epigenetic alterations discovered in human cancers. DNA hypomethylation is postulated to occur very early in almost all human cancers, perhaps facilitating genetic insta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a9ce50414b3a6502af2c30f20c73148
https://doi.org/10.1158/0008-5472.c.6497391
https://doi.org/10.1158/0008-5472.c.6497391