Zobrazeno 1 - 10
of 106
pro vyhledávání: '"G Sigthorsson"'
Autor:
Daniel F. Gudbjartsson, Hallgrimur Gudjonsson, Ingvar Bjarnason, Roy Sherwood, Johan H. Wandall, Kristleifur Kristjansson, Leif Percival Andersen, Bjarni Thjodleifsson, Nick Cariglia, Inga Reynisdottir, Vilmundur Gudnason, Jonathan B. Meddings, Matthías Kjeld, G Sigthorsson, Einar Oddsson
Publikováno v:
Gastroenterology. 124:1728-1737
One approach to unraveling the genetics of complex inherited disease, such as Crohn's disease, is to search for subclinical disease markers among unaffected family members. We assessed the possible presence, prevalence, and inheritance pattern of sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83a32c47228f8449f8a92c0cf59477d6
https://doi.org/10.1016/s0016-5085(03)00383-4
https://doi.org/10.1016/s0016-5085(03)00383-4
Publikováno v:
Alimentary Pharmacology & Therapeutics. 15:2001-2008
Background: Failure of ulcer healing may be critically important to the development of serious gastrointestinal complications in patients on long-term NSAIDs. Aim: To determine the effect of indometacin, celecoxib, a cyclooxygenase-2-specific inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60349d9f09650332d8160c55a8952d62
https://doi.org/10.1046/j.1365-2036.2001.01126.x
https://doi.org/10.1046/j.1365-2036.2001.01126.x
Autor:
Russell Foster, A Roseth, G Sigthorsson, Magne K. Fagerhol, J A Tibble, K Teahon, B Thjodleifsson, R Sherwood, Ingvar Bjarnason, S Bridger
Publikováno v:
Gut. 47:506-513
BACKGROUND AND AIMS—Assessing the presence and degree of intestinal inflammation objectively, simply, and reliably is a significant problem in gastroenterology. We assessed faecal excretion of calprotectin, a stable neutrophil specific marker, as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a02089cf206ddfb7626206ae874c8d
https://doi.org/10.1136/gut.47.4.506
https://doi.org/10.1136/gut.47.4.506
Publikováno v:
Gastroenterology. 119:15-22
Prediction of relapse of inflammatory bowel disease has important implications for therapeutic strategies. We assessed whether measurement of intestinal permeability and inflammation could predict relapse of inflammatory bowel disease (IBD).Forty-thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d508009e176612d53867db55466d59a3
https://doi.org/10.1053/gast.2000.8523
https://doi.org/10.1053/gast.2000.8523
Publikováno v:
InflammoPharmacology. 8:175-187
These studies assessed the gastrointestinal tolerability and cyclooxygenase (COX) selectivity of nimesulide in animals and man. Nimesulide (15 and 30 mg/kg) had no significant 'topical' toxicity in animals as assessed by in vivo mitochondrial morphol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa763e901d624ffdc399aadd2b41e670
https://doi.org/10.1163/15685600038215
https://doi.org/10.1163/15685600038215
Autor:
John M. Wrigglesworth, S Somasundaram, Ingvar Bjarnason, S Rafi, Robert J. Simpson, Molly Jacob, J Watts, Ashley B. Price, Arne Røseth, Russell Foster, Iggy Tavares, G Sigthorsson
Publikováno v:
Alimentary Pharmacology & Therapeutics. 14:639-650
Background The pathogenesis of NSAID-induced gastrointestinal damage is believed to involve a nonprostaglandin dependent effect as well as prostaglandin dependent effects. One suggestion is that the nonprostaglandin mechanism involves uncoupling of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7986955cf818549f02dbd7aeec4ef45
https://doi.org/10.1046/j.1365-2036.2000.00723.x
https://doi.org/10.1046/j.1365-2036.2000.00723.x
NSAID-induced gastrointestinal damage: the biochemical consequences of the 'ion trapping' hypothesis
Publikováno v:
Inflammopharmacology. 8:31-41
There is irrefutable evidence that cyclooxygenase-1 (COX-1) inhibition by itself is not the only factor in the development of the gastrointestinal damage of NSAIDs. One suggestion is that the 'topical' effect of NSAIDs is an important initiating fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e96ad9a311983bd09027d2ddebb0e7cf
https://doi.org/10.1023/b:infl.0000041130.58342.15
https://doi.org/10.1023/b:infl.0000041130.58342.15
Autor:
Ingvar Bjarnason, Ashley B. Price, Paul Thomas, Hanan Rihani, G Sigthorsson, R. John Nicholls, Arne Røseth
Publikováno v:
Diseases of the Colon & Rectum. 43:214-220
PURPOSE: Assessment of inflammation within the ileal pouch to establish a diagnosis of “pouchitis” requires both pouch endoscopy and biopsy because there can be a poor correlation between macroscopic and histologic assessments of inflammation. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d2eb5245cd3383260cf99b0730922e
https://doi.org/10.1007/bf02236986
https://doi.org/10.1007/bf02236986
Publikováno v:
Scandinavian Journal of Gastroenterology. 35:802-807
It is suggested that the gastrointestinal toxicity of conventional non-steroid anti-inflammatory drugs (NSAIDs) is due to a 'topical' effect in addition to inhibition of the mucosal constitutive cyclo-oxygenase-1 (COX-1) enzyme. COX-2 selective inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f1b88969a07ed9f27b2e6eebd55ba9
https://doi.org/10.1080/003655200750023156
https://doi.org/10.1080/003655200750023156
Autor:
Brian Gazzard, Chris Taylor, Ingvar Bjarnason, G Sigthorsson, D Sharpstone, M Coutts, R Sherwood, K Hodgson, I S Menzies
Publikováno v:
Scandinavian Journal of Gastroenterology. 35:599-606
Background: Gastrointestinal symptoms are distressing features of human immunodeficiency virus (HIV) ) infection, and management is often empirical, including withdrawal of dietary lactose. We assessed the prevalence and severity of intestinal disacc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff44408ba5b545f6891747eeea02b9f6
https://doi.org/10.1080/003655200750023552
https://doi.org/10.1080/003655200750023552