Zobrazeno 1 - 10
of 113
pro vyhledávání: '"G Scott, Worthen"'
Autor:
Amruta Naik, Kaitlyn M. Forrest, Oindrila Paul, Yasmine Issah, Utham K. Valekunja, Soon Y. Tang, Akhilesh B. Reddy, Elizabeth J. Hennessy, Thomas G. Brooks, Fatima Chaudhry, Apoorva Babu, Michael Morley, Jarod A. Zepp, Gregory R. Grant, Garret A. FitzGerald, Amita Sehgal, G. Scott Worthen, David B. Frank, Edward E. Morrisey, Shaon Sengupta
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
Optimal lung repair and regeneration are essential for recovery from viral infections, including influenza A virus (IAV). We have previously demonstrated that acute inflammation and mortality induced by IAV is under circadian control. However, it is
Externí odkaz:
https://doaj.org/article/ac4e98bc89a84f5b8ce9124207a92a10
Autor:
Sushila A. Toulmin, Chaitali Bhadiadra, Andrew J. Paris, Jeffrey H. Lin, Jeremy Katzen, Maria C. Basil, Edward E. Morrisey, G. Scott Worthen, Laurence C. Eisenlohr
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Type II alveolar cells play central roles in multiple aspects of lung biology. Here the authors show that type II alveolar cells also constitutively express MHCII, exhibit limited MHCII antigen presentation capacity, and are a component of the host r
Externí odkaz:
https://doaj.org/article/e19c792b6eed4c79a384d45bab80f5de
Autor:
Kathryn M. Rubey, Alexander R. Mukhitov, Jia Nong, Jichuan Wu, Vera P. Krymskaya, Jacob W. Myerson, G. Scott Worthen, Jacob S. Brenner
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Despite the power of antibiotics, bacterial infections remain a major killer, due to antibiotic resistance and hosts with dysregulated immune systems. We and others have been developing drug-loaded nanoparticles that home to the sites of infection an
Externí odkaz:
https://doaj.org/article/e813c9186b2f4af98701330fc592cef8
Autor:
Lei Guo, Nan Li, Zening Yang, Heng Li, Huiwen Zheng, Jinxi Yang, Yanli Chen, Xin Zhao, Junjie Mei, Haijing Shi, G. Scott Worthen, Longding Liu
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Respirovirus such as influenza virus infection induces pulmonary anti-viral immune response, orchestration of innate and adaptive immunity restrain viral infection, otherwise causes severe diseases such as pneumonia. Chemokines regulate leukocyte rec
Externí odkaz:
https://doaj.org/article/e5d0591674c34f32b9fa422742372ca7
Autor:
Nadir Yehya, Hossein Fazelinia, Deanne M. Taylor, Gladys G. Lawrence, Lynn A. Spruce, Jill M. Thompson, Susan S. Margulies, Steven H. Seeholzer, G. Scott Worthen
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Both sepsis and acute respiratory distress syndrome (ARDS) rely on imprecise clinical definitions leading to heterogeneity, which has contributed to negative trials. Because circulating protein/DNA complexes have been implicated in sepsis and ARDS, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fee87e66fb07e1e4d1862cd61420b4
https://doi.org/10.1152/ajplung.00164.2021
https://doi.org/10.1152/ajplung.00164.2021
Autor:
Andrew J Paris, Lei Guo, Ning Dai, Jeremy B Katzen, Priyal N Patel, G Scott Worthen, Jacob S Brenner
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0202456 (2019)
Many lung diseases, such as the acute respiratory distress syndrome (ARDS), display significant regional heterogeneity with patches of severely injured tissue adjacent to apparently healthy tissue. Current mouse models that aim to mimic ARDS generall
Externí odkaz:
https://doaj.org/article/a83cdd6ed33545c7a4c72087cccc4c55
Autor:
G. Scott Worthen, Ning Dai, Andrew J. Paris, Lynn A. Spruce, Steven H. Seeholzer, Joseph H. Oved, Ping Wang, Mortimer Poncz, Kandace Gollomp, Kathryn M Rubey
Publikováno v:
Blood. 137:392-397
Neutrophils are critical mediators of host defense in pathogen-induced and sterile inflammation. Excessive neutrophil activation has been associated with increased host pathology through collateral organ damage. The beneficial aspects of neutrophil a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8e81de06fe0d72761a5463dc5b190d
https://doi.org/10.1182/blood.2020005505
https://doi.org/10.1182/blood.2020005505
Autor:
Bing He, Martha S. Jordan, Dana C. Bellissimo, Qin Zhu, G. Scott Worthen, Sumedha Bagga, Nancy A. Speck, D. Gary Gilliland, Chia hui Chen, Gerald Wertheim, Chung Tsai Lee, Kai Tan
Publikováno v:
Blood Advances. 4:1145-1158
RUNX1 is frequently mutated in myeloid and lymphoid malignancies. It has been shown to negatively regulate Toll-like receptor 4 (TLR4) signaling through nuclear factor κB (NF-κB) in lung epithelial cells. Here we show that RUNX1 regulates TLR1/2 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705b2ff26cd0d6a0379d7f6e8a798d32
https://doi.org/10.1182/bloodadvances.2019000785
https://doi.org/10.1182/bloodadvances.2019000785
Publikováno v:
Infection and Immunity. 90
Acute lung injury (ALI) induced by lipopolysaccharide (LPS) is a major cause of mortality among humans. ALI is characterized by microvascular protein leakage, neutrophil influx, and expression of proinflammatory mediators, followed by severe lung dam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846f55a8d95e3a3fb6bd93e1c8244e92
https://doi.org/10.1128/iai.00014-22
https://doi.org/10.1128/iai.00014-22
Autor:
Haijing Shi, Jinxi Yang, Yanli Chen, Heng Li, Lei Guo, Nan Li, Junjie Mei, Longding Liu, Zening Yang, Xin Zhao, G. Scott Worthen, Huiwen Zheng
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Respirovirus such as influenza virus infection induces pulmonary anti-viral immune response, orchestration of innate and adaptive immunity restrain viral infection, otherwise causes severe diseases such as pneumonia. Chemokines regulate leukocyte rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7b59e1a480da8d558e1b81b48d43d4