Zobrazeno 1 - 10
of 544
pro vyhledávání: '"G Schulman"'
Autor:
Kristine Griffett, Matthew Hayes, Gonzalo Bedia-Diaz, Kevin Appourchaux, Ryan Sanders, Michael P. Boeckman, Thomas Koelblen, Jinsong Zhang, Ira G. Schulman, Bahaa Elgendy, Thomas P. Burris
Publikováno v:
ACS Chemical Biology. 17:1143-1154
Hyperlipidemia and increased circulating cholesterol levels are associated with increased cardiovascular disease risk. The liver X receptors (LXRs) are regulators of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8cf044d8bb44c68f0d4e829ef7df91
https://doi.org/10.1021/acschembio.2c00057
https://doi.org/10.1021/acschembio.2c00057
Autor:
Eric D. Bischoff, Chris L. Daige, Mary Petrowski, Harry Dedman, Jennifer Pattison, Joseph Juliano, Andrew C. Li, Ira G. Schulman
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 5, Pp 900-906 (2010)
The liver X receptors LXRα and LXRβ play critical roles in maintaining lipid homeostasis by functioning as transcription factors that regulate genetic networks controlling the transport, catabolism, and excretion of cholesterol. The studies describ
Externí odkaz:
https://doaj.org/article/8bbe8d9c41854b5d80a8662666178370
Autor:
Ira G. Schulman, Daniel Hovdal, Emma Evertsson, Emma Bratt, Anna Y. Belorusova, Eva-Lotte Lindstedt, Peter Åkerblad, Jenny Sandmark, Ingela Maxvall
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-13 (2019)
Communications Biology
'Communications Biology ', vol: 2, pages: 431-1-431-13 (2019)
Communications Biology
'Communications Biology ', vol: 2, pages: 431-1-431-13 (2019)
Liver X receptors (LXRs) are attractive drug targets for cardiovascular disease treatment due to their role in regulating cholesterol homeostasis and immunity. The anti-atherogenic properties of LXRs have prompted development of synthetic ligands, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fefa10f2b5d5c6ae47b7a89b555f36c5
http://link.springer.com/article/10.1038/s42003-019-0675-0
http://link.springer.com/article/10.1038/s42003-019-0675-0
Autor:
Ira G. Schulman, Lillian Russo-Savage
Publikováno v:
Biochim Biophys Acta Mol Basis Dis
The liver x receptors LXRα (NR1H3) and LXRβ (NR1H2) are members of the nuclear hormone receptor superfamily of ligand dependent transcription factors that regulate transcription in response to the direct binding of cholesterol derivatives. Studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4977d5d9aab1353d07ed62d67359891e
https://pubmed.ncbi.nlm.nih.gov/33713792
https://pubmed.ncbi.nlm.nih.gov/33713792
Autor:
Shun Hang Chan, Jerry Angdisen, Timothy F. Osborne, Alexander F. Koeppel, Ying Ju Chang, Stephen D. Turner, Sophie R. Liebergall, Ira G. Schulman
Publikováno v:
Mol Cell Biol
Immune cell function can be modulated by changes in lipid metabolism. Our studies indicate that cholesterol and fatty acid synthesis increases in macrophages between 12 and 18 h after the activation of Toll-like receptors with proinflammatory stimuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20c03caaa3ab7fbe3e938f389e70903
https://europepmc.org/articles/PMC6944475/
https://europepmc.org/articles/PMC6944475/
Autor:
Ira G. Schulman, Kathryn E. Marqueen, Norbert Leitinger, Renata Polanowska-Grabowska, Rachael Griffiths, Sarah R. Breevoort, Jerry Angdisen, Samantha E. Adamson
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38:1020-1029
Objective— Inflammatory macrophages promote the development of atherosclerosis. We have identified the adaptor protein Dab2 (disabled homolog 2) as a regulator of phenotypic polarization in macrophages. The absence of Dab2 in myeloid cells promotes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11f91360ec8efd8a067299b78add8b1a
https://doi.org/10.1161/atvbaha.117.310467
https://doi.org/10.1161/atvbaha.117.310467
Autor:
Ira G. Schulman
Publikováno v:
FEBS Letters. 591:2978-2991
The response of immune cells to pathogens is often associated with changes in the flux through basic metabolic pathways. Indeed, in many cases changes in metabolism appear to be necessary for a robust immune response. The Liver X receptors (LXRs) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afcf354fc53bb52a2a10613fd2e4a70
https://doi.org/10.1002/1873-3468.12702
https://doi.org/10.1002/1873-3468.12702
Publikováno v:
Forensic science review. 30(1)
The accuracy of textile damage analyses was evaluated by laboratory tests carried out by trained experts. The analyzed damages were prepared by various methods, including stabbing, cutting, shooting, heating/burning, etc. A number of damages were age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3bf64fe3a9861f90fe9b39d640801288
https://pubmed.ncbi.nlm.nih.gov/29273571
https://pubmed.ncbi.nlm.nih.gov/29273571
Autor:
Thomas J. Stout, Brett B. Busch, Todd G. Kirchgessner, Michael Charles Nyman, Tie-Lin Wang, Ruth R. Wexler, Lam Nguyen, Ellen K. Kick, Brandee L. Wagner, Grace Yan, Yinong Xie, Edwin J. Schweiger, Artur Plonowski, Ira G. Schulman, Brenton T. Flatt, Jacek Ostrowski, Max H. Nanao, Richard Martin, Raju Mohan, Xiao-Hui Gu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:372-377
A series of biaryl pyrazole and imidazole Liver X Receptor (LXR) partial agonists has been synthesized displaying LXRβ selectivity. The LXRβ selective partial agonist 18 was identified with potent induction of ATP binding transporters ABCA1 and ABC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7244efc41c2284fe9a58be668b38fd90
https://doi.org/10.1016/j.bmcl.2014.11.029
https://doi.org/10.1016/j.bmcl.2014.11.029
Autor:
Salma M.Z. Al-Kindy, Stephen G. Schulman, Ahmed F. Al-Harasi, Fakhr Eldin O. Suliman, Nada A. Al-Sharji, Haider A.J. Al-Lawati
Publikováno v:
Arabian Journal of Chemistry, Vol 10, Iss S1, Pp S114-S120 (2017)
2,7-Diethylamino-2-oxo-2H-chromen-3-yl benzothiazole-6-sulfonyl chlorides dye (Coumarin 6-SO2Cl) was used to synthesize anilines and amino acid derivatives. The electronic absorption and emission spectra of the label and its derivatives in organic so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93bfaddfd60238702f243c8d6b38d3c1
http://www.sciencedirect.com/science/article/pii/S1878535212001694
http://www.sciencedirect.com/science/article/pii/S1878535212001694