Výsledky vyhledávání - "G S Gilkeson"

Influence of VH CDR3 arginine and light chain pairing on DNA reactivity of a bacterial DNA-induced anti-DNA antibody from a BALB/c mouse

Autor: M K Wloch, S H Clarke, G S Gilkeson

Publikováno v: The Journal of Immunology. 159:6083-6090

Anti-DNA induced in BALB/c mice by immunization with bacterial (Escherichia coli) DNA resemble spontaneous anti-DNA from lupus mice in V gene use and cross-reactivity with other nuclear Ags, but lack the high V(H) CDR3 arginine content seen in anti-D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b784944a117e15e59a7c4b6116aecf6b
https://doi.org/10.4049/jimmunol.159.12.6083

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Molecular properties of anti-DNA induced in preautoimmune NZB/W mice by immunization with bacterial DNA

Autor: M K Wloch, A L Alexander, A M Pippen, D S Pisetsky, G S Gilkeson

Publikováno v: The Journal of Immunology. 158:4500-4506

To elucidate the mechanism of Ag drive in the anti-DNA response, the Ab response to bacterial DNA has been analyzed in normal and autoimmune mice. Preautoimmune NZB/W mice immunized with Escherichia coli dsDNA produce Abs that resemble spontaneous au

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28bb69bb145b1febe107e24300b8f87d
https://doi.org/10.4049/jimmunol.158.9.4500

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Murine glomerulotropic monoclonal antibodies are highly oligoclonal and exhibit distinctive molecular features

Autor: J B Lefkowith, R Di Valerio, J Norris, G D Glick, A L Alexander, L Jackson, G S Gilkeson

Publikováno v: The Journal of Immunology. 157:1297-1305

We recently produced a panel of seven glomerular-binding mAbs from a nephritic MRL-lpr mouse that bind to histones/nucleosomes (group I) or DNA (group II) adherent to glomerular basement membrane. To elucidate the molecular basis of their binding and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::821d7cd1aacd3dbbafc57c75bf51e53c
https://doi.org/10.4049/jimmunol.157.3.1297

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Molecular characterization of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Differences from spontaneous anti-DNA in the content and location of VH CDR3 arginines

Autor: G S Gilkeson, D D Bloom, D S Pisetsky, S H Clarke

Publikováno v: The Journal of Immunology. 151:1353-1364

Immunization of normal mice with bacterial DNA induces a significant anti-DNA response that includes antibodies resembling some lupus anti-DNA in their binding properties, although lacking specificity for mammalian dsDNA. To determine the structure o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7287d551b65af767bd4dafd5bfbe86db
https://doi.org/10.4049/jimmunol.151.3.1353

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Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA

Autor: J P Messina, G S Gilkeson, D S Pisetsky

Publikováno v: The Journal of Immunology. 147:1759-1764

Although DNA is generally considered to be a poor immunogen, recent evidence suggests that DNA from various species differ in their immunologic activity and that bacterial DNA, unlike mammalian DNA, can induce significant antibody responses in mice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e219021da0620ac32c3098137ff972cd
https://doi.org/10.4049/jimmunol.147.6.1759

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Smoking and use of hair treatments in relation to risk of developing systemic lupus erythematosus

Autor: G S, Cooper, M A, Dooley, E L, Treadwell, E W, St Clair, G S, Gilkeson

Publikováno v: The Journal of rheumatology. 28(12)

To examine the association between smoking and hair treatments (dyes, permanents) and risk of developing systemic lupus erythematosus (SLE).Patients (n = 265) diagnosed between January 1, 1995, and July 31, 1999, were recruited through 4 university b

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https://pubmed.ncbi.nlm.nih.gov/11764212

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Peroxynitrite formation and decreased catalase activity in autoimmune MRL-lpr/lpr mice

Autor: T, Keng, C T, Privalle, G S, Gilkeson, J B, Weinberg

Publikováno v: Molecular medicine (Cambridge, Mass.). 6(9)

BACKGROUND: (MRL)-lpr/lpr mice spontaneously develop autoimmune disease characterized by arthritis and glomerulonephritis. Nitric oxide is postulated to play a role in the disease pathogenesis, as mice treated with the nitric oxide synthase inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b1e9d28ace7720ee417e7e975b4be338
https://pubmed.ncbi.nlm.nih.gov/11071272

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Effects of bacterial DNA on cytokine production by (NZB/NZW)F1 mice

Autor: G S, Gilkeson, J, Conover, M, Halpern, D S, Pisetsky, A, Feagin, D M, Klinman

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(8)

Microbial DNA has multiple immune effects including the capacity to induce polyclonal B cell activation and cytokine production in normal mice. We recently described the accelerated induction of anti-DNA Abs in NZB/NZW mice immunized with Escherichia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1809dd96100ce9d1418f1f817fabb50c
https://pubmed.ncbi.nlm.nih.gov/9780154

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