Zobrazeno 1 - 10
of 18
pro vyhledávání: '"G S, Salvesen"'
Autor:
J C, Timmer, G S, Salvesen
Publikováno v:
Cell Death & Differentiation. 14:66-72
The relatively common occurrence of sequences within proteins that match the consensus substrate specificity of caspases in intracellular proteins suggests a multitude of substrates in vivo - somewhere in the order of several hundred in humans alone.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd903c2f08bec107920ff1d0636c195
https://doi.org/10.1038/sj.cdd.4402059
https://doi.org/10.1038/sj.cdd.4402059
Publikováno v:
The Biochemical journal. 357(Pt 2)
Caspases play an important role in the ability of animal cells to kill themselves by apoptosis. Caspase activity is regulated in vivo by members of three distinct protease inhibitor families, two of which, baculovirus p35 and members of the inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d812acde1d53321148cb25297551338
https://pubmed.ncbi.nlm.nih.gov/11439111
https://pubmed.ncbi.nlm.nih.gov/11439111
Autor:
G A, Silverman, P I, Bird, R W, Carrell, F C, Church, P B, Coughlin, P G, Gettins, J A, Irving, D A, Lomas, C J, Luke, R W, Moyer, P A, Pemberton, E, Remold-O'Donnell, G S, Salvesen, J, Travis, J C, Whisstock
Publikováno v:
The Journal of biological chemistry. 276(36)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e3a59b3f2e351d05d58f00395eae288a
https://pubmed.ncbi.nlm.nih.gov/11435447
https://pubmed.ncbi.nlm.nih.gov/11435447
Autor:
V, Stoka, B, Turk, S L, Schendel, T H, Kim, T, Cirman, S J, Snipas, L M, Ellerby, D, Bredesen, H, Freeze, M, Abrahamson, D, Bromme, S, Krajewski, J C, Reed, X M, Yin, V, Turk, G S, Salvesen
Publikováno v:
The Journal of biological chemistry. 276(5)
We investigated the mechanism of lysosome-mediated cell death using purified recombinant pro-apoptotic proteins, and cell-free extracts from the human neuronal progenitor cell line NT2. Potential effectors were either isolated lysosomes or purified l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d398d72474dfdaba4a8c629b7e483b3d
https://pubmed.ncbi.nlm.nih.gov/11073962
https://pubmed.ncbi.nlm.nih.gov/11073962
Autor:
Q, Zhou, G S, Salvesen
Publikováno v:
Methods in enzymology. 322
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::744d127c74f5e7592f6f8cec7bc8dd8f
https://pubmed.ncbi.nlm.nih.gov/10914011
https://pubmed.ncbi.nlm.nih.gov/10914011
Autor:
H R, Stennicke, G S, Salvesen
Publikováno v:
Methods in enzymology. 322
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b7897f57a9bdfd8c65c561f9b47d8596
https://pubmed.ncbi.nlm.nih.gov/10914007
https://pubmed.ncbi.nlm.nih.gov/10914007
Publikováno v:
Journal of clinical immunology. 19(6)
Caspases are cysteine proteases that are specific for aspastic acid residues. These enzymes have been extensively characterized as integral and highly conserved components of a variety of cell death programs. Cowpox and several insect viruses have ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b97658e00fc694162b0a6b0e39a7932
https://pubmed.ncbi.nlm.nih.gov/10634212
https://pubmed.ncbi.nlm.nih.gov/10634212
Publikováno v:
The Journal of biological chemistry. 274(40)
The abundant nuclear enzyme poly(ADP-ribose) polymerase (PARP) synthesizes poly(ADP-ribose) in response to DNA strand breaks. During almost all forms of apoptosis, PARP is cleaved by caspases, suggesting the crucial role of its inactivation. A few st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::af3e5f04b837245e4fb684ca2300601a
https://pubmed.ncbi.nlm.nih.gov/10497198
https://pubmed.ncbi.nlm.nih.gov/10497198
Autor:
B B, Wolf, J C, Goldstein, H R, Stennicke, H, Beere, G P, Amarante-Mendes, G S, Salvesen, D R, Green
Publikováno v:
Blood. 94(5)
Apoptosis and platelet activation share common morphological and biochemical features. Because caspases are essential mediators of apoptosis, we examined whether platelets contain these proteinases and use them during platelet activation. Human plate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ee3b0f01e753b6751f3d70c97de8fef
https://pubmed.ncbi.nlm.nih.gov/10477693
https://pubmed.ncbi.nlm.nih.gov/10477693
Autor:
X, Yang, H R, Stennicke, B, Wang, D R, Green, R U, Jänicke, A, Srinivasan, P, Seth, G S, Salvesen, C J, Froelich
Publikováno v:
The Journal of biological chemistry. 273(51)
Granzyme B (GrB) is predicted to trigger apoptosis by activating preferred caspases, but the zymogens that are directly processed by the granzyme and the requirements for these interactions remain unclarified. We examined this dilemma by comparing th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5a2793d6f52328dcde70af2f5e685f0
https://pubmed.ncbi.nlm.nih.gov/9852092
https://pubmed.ncbi.nlm.nih.gov/9852092