Zobrazeno 1 - 10
of 21
pro vyhledávání: '"G S, Korbutt"'
Publikováno v:
Cell Transplantation, Vol 10 (2001)
The development of effective protocols for the low-temperature banking of pancreatic islets is an important step in islet transplantation for the treatment of type I diabetes mellitus. We have been exploring the use of islets from the newborn pig as
Externí odkaz:
https://doaj.org/article/f8f393cf31b04d22acdfbb1934de40c5
Publikováno v:
Diabetes. 46:317-322
Autor:
G. S. Korbutt, D. G. Pipeleers
Publikováno v:
Diabetes. 41:299-307
Publikováno v:
Annals of the New York Academy of Sciences. 944
The mechanisms involved in islet neogenesis have remained largely unexplored due to lack of an appropriate model. Furthermore, with the recent advances in islet transplantation, the need for alternative islet tissue sources is greater than ever. Ther
Publikováno v:
Transplantation. 72(4)
Islet isolation from the pancreatic tissue matrix remains highly variable. Recent evidence suggests that intrinsic human pancreatic proteases, including trypsin, may inhibit effective collagenase enzymatic activity during islet isolation, thereby imp
Publikováno v:
Transplantation. 70(6)
Insulin has been implicated in the pathogenesis of type 1 diabetes and oral administration of insulin has been shown to delay the onset of diabetes in NOD mice. In this study we determined whether a single footpad injection of insulin will protect sy
Publikováno v:
Transplantation. 64(7)
Inasmuch as cryopreservation can facilitate clinical islet transplantation by providing a means of storing supplemental islets in order to augment marginally adequate grafts, protocols are needed to allow for a minimal loss in viable beta cells. By r
Publikováno v:
Transplantation. 63(7)
Localized delivery of immunosuppressive molecules, limited to the graft site, may allow transplantation of tissue in the absence of systemic immunosuppressive agents. We tested whether purified mouse islets that had been engineered to produce human C
Publikováno v:
Advances in experimental medicine and biology. 426
Publikováno v:
Transplantation. 61(11)
To utilize gene therapy, we required an efficient method to transfect intact islets before their use in transplantation. The biolistic method transforms cells by bombarding them with microprojectiles coated with DNA. Once internalized, the DNA is sol