Zobrazeno 1 - 10 of 35 pro vyhledávání: '"G Robin Barclay"'
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Akademický článek
Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections.
Autor: Jacob D Estes, Levelle D Harris, Nichole R Klatt, Brian Tabb, Stefania Pittaluga, Mirko Paiardini, G Robin Barclay, Jeremy Smedley, Rhonda Pung, Kenneth M Oliveira, Vanessa M Hirsch, Guido Silvestri, Daniel C Douek, Christopher J Miller, Ashley T Haase, Jeffrey Lifson, Jason M Brenchley
Publikováno v: PLoS Pathogens, Vol 6, Iss 8, p e1001052 (2010)
The chronic phase of HIV infection is marked by pathological activation of the immune system, the extent of which better predicts disease progression than either plasma viral load or CD4(+) T cell count. Recently, translocation of microbial products
Externí odkaz: https://doaj.org/article/b5191db7f6d542828d9bd9b2ceac4d03
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2
The constituents and mechanisms of generation of ‘endothelial cell—colony forming units’
Autor: Abigail Short, Gareth J. Padfield, G. Robin Barclay, David E. Newby, Olga Tura-Ceide, Kay Samuel, Nicholas L. Mills, Marc Turner
Publikováno v: Cardiovascular Research. 100:288-296
Aims The formation of endothelial cell-colony forming units (EC-CFUs) is increased by vascular injury, although their function in vivo is unclear. We, therefore, examined the constituents of EC-CFUs and the mechanisms of their generation. Methods and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad8207c02283f9cb63e89ab281ae4ba
https://doi.org/10.1093/cvr/cvt182
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3
Human embryonic stem cells rapidly take up and then clear exogenous human and animal prionsin vitro
Autor: Jean Manson, Enrico Cancellotti, G. Robin Barclay, Kay Samuel, Paul A. De Sousa, Matthew Bishop, Steve Pells, Mark Head, Zuzana Krejciova, James W. Ironside, Marc Turner, Paz Freile
Publikováno v: The Journal of Pathology. 223:635-645
Susceptibility to prion infection involves interplay between the prion strain and host genetics, but expression of the host-encoded cellular prion protein is a known prerequisite. Here we consider human embryonic stem cell (hESC) susceptibility by ch
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3db238f4dfe3fd5e4a9053b90e37211d
https://doi.org/10.1002/path.2832
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4
Circulating endothelial progenitor cells are not affected by acute systemic inflammation
Autor: Olga Tura, Marlieke L. A. Haeck, Abigail Short, Elizabeth Freyer, Gareth J. Padfield, David E. Newby, Nicholas L. Mills, G. Robin Barclay
Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 298:H2054-H2061
Vascular injury causes acute systemic inflammation and mobilizes endothelial progenitor cells (EPCs) and endothelial cell (EC) colony-forming units (EC-CFUs). Whether such mobilization occurs as part of a nonspecific acute phase response or is a phen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5aa959d7f29dbb97ebf66d36c83f7d7
https://doi.org/10.1152/ajpheart.00921.2009
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5
Three-colour flow cytometric detection of PrP in ovine leukocytes
Autor: G. Robin Barclay, Philip Steele, Jeanie Finlayson, Scott L. Hamilton, Mary-Jo Anderson, Mara Rocchi, Samantha L. Eaton, Francesca Chianini
Publikováno v: Veterinary Immunology and Immunopathology. 116:172-181
PrPc (cellular prion protein, CD230) expression by subpopulations of lymphoid cells has been widely investigated in a variety of species, possibly because of the possible link between transmissible spongiform encephalopathies (TSE) transmission and b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1913cf20c9ed19f4351b97776b1470
https://doi.org/10.1016/j.vetimm.2007.01.012
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6
Variation in concentration of prion protein in the peripheral blood of patients with variant and sporadic Creutzfeldt-Jakob disease detected by dissociation enhanced lanthanide fluoroimmunoassay and flow cytometry
Autor: Marc Turner, Ian MacGregor, Tim Fagge, Mark Head, James W. Ironside, G. Robin Barclay
Publikováno v: Transfusion. 45:504-513
BACKGROUND: A highly sensitive dissociation-enhanced lanthanide fluoroimmunoassay (DELFIA) and flow cytometry techniques have previously been developed and employed to characterize soluble cellular prion protein (PrPc) expression in whole blood and s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6a5249f48436641eb1636e2bda811d
https://doi.org/10.1111/j.0041-1132.2005.04342.x
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7
Comparative analysis of normal prion protein expression on human, rodent, and ruminant blood cells by using a panel of prion antibodies
Autor: G. Robin Barclay, Marc Turner, Christine Farquhar, Sue I. Halliday, E. Fiona Houston
Publikováno v: Transfusion. 42:517-526
BACKGROUND: It is not known whether variant CJD can be transmitted within the human population by blood transfusion. The expression of normal cellular prion protein (PrPC) by different blood cell types may permit selective uptake and dissemination of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d119157a4dc1e9526d2ef68a0a904b5
https://doi.org/10.1046/j.1537-2995.2002.00095.x
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8
Percutaneous coronary intervention causes a rapid but transient mobilisation of CD34(+)CD45(-) cells
Autor: Nicholas L. Mills, Olga Tura-Ceide, Gareth J. Padfield, G. Robin Barclay, David E. Newby, Marc Turner, Elizabeth Freyer
Publikováno v: Padfield, G J, Tura-Ceide, O, Freyer, E, Barclay, G R, Turner, M, Newby, D E & Mills, N L 2014, ' Percutaneous coronary intervention causes a rapid but transient mobilisation of CD34(+)CD45(-) cells ', Open heart, vol. 1, no. 1, e000047 . https://doi.org/10.1136/openhrt-2014-000047
Open Heart
OBJECTIVE: Circulating CD34(+)CD45(-) cell concentrations are increased in patients with coronary artery disease, however their pathophysiological significance is unknown. We determined CD34(+)CD45(-) cell concentrations following percutaneous corona
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6dccf28c3b3121ba4958f3c9b197c94
https://hdl.handle.net/20.500.11820/6e36faa8-7e75-4565-9fa0-f9d2d8fd69e2
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9
Endotoxin-neutralizing capacity of serum from cardiac surgical patients
Autor: Frances Vela-Cantos, Carol A. Bodian, Elliott Bennett-Guerrero, Dennis E. Feierman, Michael G. Mythen, Patricia L. Weng, G. Robin Barclay
Publikováno v: Journal of Cardiothoracic and Vascular Anesthesia. 15:451-454
To determine if endotoxin core antibody (EndoCAb) from the serum of cardiac surgical patients neutralizes endotoxin in an ex vivo biologic assay.Prospective blinded cohort study.Academic medical center.Patients (n = 203) undergoing cardiac surgery.Se
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf18b97363ff23a6257597367514545
https://doi.org/10.1053/jcan.2001.24980
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10
Relationship Between Preoperative Endotoxin Immune Status, Gut Perfusion, and Outcome From Cardiac Valve Replacement Surgery
Autor: Samuel J. Machin, S McDonald, G. Robin Barclay, G Purdy, A. R. Webb, Rebecca Cardigan, C. Hamilton-Davies
Publikováno v: Chest. 112:1189-1196
Endotoxin is a powerful trigger of systemic inflammation. Since cardiac surgery exposes patients to endotoxemia, this study was set up to define the relationship between preoperative endogenous endotoxin immune status, gut perfusion, and outcome foll
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f4488111a3e0d966375e2732303eb4
https://doi.org/10.1378/chest.112.5.1189
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