Výsledky vyhledávání - "G R Thompson"

Akademický článek

Decreased production of low density lipoprotein by atorvastatin after apheresis in homozygous familial hypercholesterolemia

Autor: A D Marais, R P Naoumova, J C Firth, C Penny, C K Neuwirth, G R Thompson

Publikováno v: Journal of Lipid Research, Vol 38, Iss 10, Pp 2071-2078 (1997)

Apheresis only partially controls raised low density lipoprotein cholesterol levels in patients with homozygous familial hypercholesterolemia, who usually respond poorly to lipid-lowering drugs. The efficacy and mechanism of action of a new 3-hydroxy

Externí odkaz: https://doaj.org/article/7b14782859364aa7bc9320dbb9e532ec

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Akademický článek

Prolonged inhibition of cholesterol synthesis explains the efficacy of atorvastatin

Autor: R P Naoumova, S Dunn, L Rallidis, O Abu-Muhana, C Neuwirth, N B Rendell, G W Taylor, G R Thompson

Publikováno v: Journal of Lipid Research, Vol 38, Iss 7, Pp 1496-1500 (1997)

HMG-CoA reductase inhibitors or statins are effective in both the primary and secondary prevention of coronary heart disease, the extent of benefit being proportional to the reduction in low density lipoprotein (LDL) cholesterol achieved. Atorvastati

Externí odkaz: https://doaj.org/article/9c33680c53c2432f91aed90ab9a08bb8

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Akademický článek

Role of cholesterol in regulating apolipoprotein B secretion by the liver

Autor: G R Thompson, R P Naoumova, G F Watts

Publikováno v: Journal of Lipid Research, Vol 37, Iss 3, Pp 439-447 (1996)

The review examines the evidence that the supply of cholesterol available for incorporation into nascent lipoprotein particles exerts a regulatory influence on apolipoprotein (apo) B secretion by the liver. Support for this hypothesis comes both from

Externí odkaz: https://doaj.org/article/9b44393d361a4495ad45b2f386938a75

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Akademický článek

Characterization of mutations in the low density lipoprotein (LDL)-receptor gene in patients with homozygous familial hypercholesterolemia, and frequency of these mutations in FH patients in the United Kingdom

Autor: J C Webb, X M Sun, S N McCarthy, C Neuwirth, G R Thompson, B L Knight, A K Soutar

Publikováno v: Journal of Lipid Research, Vol 37, Iss 2, Pp 368-381 (1996)

Mutations in the gene for the low density lipoprotein (LDL) receptor have been identified in 15 patients with homozygous familial hypercholesterolemia (FH). Five patients are homozygous at the LDL-receptor locus; their mutant alleles include Glu387Ly

Externí odkaz: https://doaj.org/article/4fd1f6fe26884d86a82a968125377cbb

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Akademický článek

Acute and chronic effects on cholesterol biosynthesis of LDL-apheresis with or without concomitant HMG-CoA reductase inhibitor therapy.

Autor: M Pfohl, R P Naoumova, C Klass, W Knisel, B Jakober, T Risler, G R Thompson

Publikováno v: Journal of Lipid Research, Vol 35, Iss 11, Pp 1946-1955 (1994)

To determine the acute and long-term effects of low density lipoprotein (LDL) reduction on cholesterol biosynthesis, we studied changes in the cholesterol precursors mevalonic acid (MVA) and lathosterol in patients with heterozygous familial hypercho

Externí odkaz: https://doaj.org/article/5b61708483e046d3a4bf82aa6ae2a686

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Akademický článek

Behavior of human apolipoprotein A-I: phospholipid and apoHDL:phospholipid complexes in vitro and after injection into rabbits

Autor: J Koizumi, M Kano, K Okabayashi, A Jadhav, G R Thompson

Publikováno v: Journal of Lipid Research, Vol 29, Iss 11, Pp 1405-1415 (1988)

Apolipoprotein A-I was purified from human high density lipoprotein and complexed with polyunsaturated phosphatidylcholine (PC) in deoxycholate (Lipostabil); the bile salt was removed subsequently by dialysis. The behavior of the resultant apoA-I/PC

Externí odkaz: https://doaj.org/article/0339dda1a2654f48989c14403fe2532b

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