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Structural and functional characterization of the HPV16 E7 protein expressed in bacteria

Autor: G, Pahel, A, Aulabaugh, S A, Short, J A, Barnes, G R, Painter, P, Ray, W C, Phelps

Publikováno v: The Journal of biological chemistry. 268(34)

The E7 gene of the human papillomaviruses (HPV) encodes a 98-amino acid, multifunctional nuclear phosphoprotein with functional and structural similarities to adenovirus E1A and the papovavirus T antigens. E7 is a viral oncoprotein, which will cooper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd960a3410bdfff2ad5537c1006be89b
https://pubmed.ncbi.nlm.nih.gov/8245034

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Pharmacokinetics, oral bioavailability, and metabolic disposition in rats of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analog active against human immunodeficiency virus and hepatitis B virus

Autor: Donald J. Nelson, L St John, L C Taylor, Furfine Eric Steven, G R Painter, P A Furman, Lloyd Frick, D C Liotta

Publikováno v: Antimicrobial agents and chemotherapy. 37(11)

The pharmacokinetics and metabolism of the potent anti-human immunodeficiency virus and anti-hepatitis B virus compound, (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine (FTC), were investigated in male CD rats. Plasma clearance of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ed684311e5fb437c5341cde6ffa017
https://pubmed.ncbi.nlm.nih.gov/8285607

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The 5'-triphosphates of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolane-5-yl]cytosine equally inhibit human immunodeficiency virus type 1 reverse transcriptase

Autor: Jeanne E. Wilson, K Borroto-Esoda, D C Liotta, G R Painter, P A Furman, J L Martin, Sam Hopkins

Publikováno v: Antimicrobial agents and chemotherapy. 37(8)

The (-) enantiomer of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolane-5-yl]cytosine is a potent inhibitor of human immunodeficiency virus type 1 in vitro. The 5'-triphosphates of the (-) and (+) enantiomers equally inhibited the production of full-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4cf473289e7b9d80976cdf683a98995
https://pubmed.ncbi.nlm.nih.gov/7692813

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Role of desolvation energy in the nonfacilitated membrane permeability of dideoxyribose analogs of thymidine

Autor: L L, Wright, G R, Painter

Publikováno v: Molecular pharmacology. 41(5)

The ability of thymidine and four dideoxyribose analogs of thymidine to cross phase barriers, such as those encountered at the exo and endo faces of a membrane, has been studied in a two-phase water/chloroform system. The rate constants for entering,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5d10502b9f3aeff16e6720a54b49085a
https://pubmed.ncbi.nlm.nih.gov/1588926

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Initial binding of 2'-deoxynucleoside 5'-triphosphates to human immunodeficiency virus type 1 reverse transcriptase

Autor: G R, Painter, L L, Wright, S, Hopkins, P A, Furman

Publikováno v: The Journal of biological chemistry. 266(29)

Human immunodeficiency virus type 1 reverse transcriptase (EC 2.7.7.49), a heterodimer consisting of two polypeptide chains of molecular weights 66,000 and 51,000, fluoresces due to the presence of 36 tryptophan residues with an emission peak centere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ba1e7bbad4ad246d8d6a56cbd509c2e
https://pubmed.ncbi.nlm.nih.gov/1717463

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