Zobrazeno 1 - 7
of 7
pro vyhledávání: '"G R Ewoldt"'
Autor:
R A Gault, G R Ewoldt, Chih-Min Kam, James C. Powers, Susan L. Woodard, N. J. Allison, Ahmed S. Abuelyaman, Dorothy Hudig, U. Winkler
Publikováno v:
Molecular Immunology. 33:615-623
Cytotoxic lymphocytes and natural killer cells are able to kill their target cells in minutes. The death of the target cell occurs after the release of cytoplasmic granules from the effector cell. These granules contain the pore-forming protein perfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0e8a541fa533148a17dbf81732854c
https://doi.org/10.1016/0161-5890(96)00025-9
https://doi.org/10.1016/0161-5890(96)00025-9
Publikováno v:
Immunogenetics. 45:452-454
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4375964da1333578013e2fef2b0758
https://doi.org/10.1007/s002510050231
https://doi.org/10.1007/s002510050231
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(12)
Anergic T cells display a marked decrease in their ability to produce IL-2 even in the presence of optimal TCR and costimulatory signals. Using IL-2 enhancer/promoter-driven reporter constructs, we have previously identified a region that appears to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bb2ec9d62b7233626677049159b64234
https://pubmed.ncbi.nlm.nih.gov/10586058
https://pubmed.ncbi.nlm.nih.gov/10586058
Autor:
G R, Ewoldt, M J, Smyth, P K, Darcy, J L, Harris, C S, Craik, B, Horowitz, S L, Woodard, J C, Powers, D, Hudig
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 158(10)
Serine proteases (granzymes) in killer lymphocytes are required for lymphocyte cytotoxic granules to lyse target cells. Herein we report the development of a 3-step PCR cloning technique to amplify novel granzyme genes and two new rat granzymes are d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::301f04543ff0c72234ab6ccbc961ce15
https://pubmed.ncbi.nlm.nih.gov/9144469
https://pubmed.ncbi.nlm.nih.gov/9144469
Publikováno v:
Current opinion in immunology. 5(1)
A subfamily of serine proteases is uniquely expressed by cytotoxic natural killer lymphocytes and T cells. Protease cleavage of different natural substrates is now implicated in the cytotoxic: mechanisms of target cell membrane pore formation, DNA fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4530e4e37a63d45e97916794cae5b93c
https://pubmed.ncbi.nlm.nih.gov/8452680
https://pubmed.ncbi.nlm.nih.gov/8452680
Autor:
Dorothy Hudig, Dale Netski, Chih-Min Kam, Ming T. Wang, N. Janine Allison, Timothy M. Pickett, U. Winkler, G R Ewoldt, James C. Powers, Shinjiro Odake, Doug Redelman, Ruth Gault, Susan J. Zunino
Publikováno v:
Cytotoxic Cells: Recognition, Effector Function, Generation, and Methods ISBN: 9781468468168
Serine proteases initiate several complex biochemical responses to sudden, life-threatening situations. The immediate and localized activation of coagulant serine proteases prevents mammals from bleeding to death. The immediate activation of compleme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e317ce76e940c92d35b1325f575cb682
https://doi.org/10.1007/978-1-4684-6814-4_27
https://doi.org/10.1007/978-1-4684-6814-4_27
Publikováno v:
Molecular immunology. 29(6)
Cytolytic granules purified from natural killer lymphocytes (NK) contain a pore-forming protein (perforin) and a number of serine proteases. When these proteases are inhibited by serine protease-specific isocoumarin reagents the serine proteases are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d13189937b58c62f8c3e7f4a4648d8
https://pubmed.ncbi.nlm.nih.gov/1603092
https://pubmed.ncbi.nlm.nih.gov/1603092