Zobrazeno 1 - 10 of 43 pro vyhledávání: '"G R Crabtree"'
1
Redundant expression but selective utilization of nuclear factor of activated T cells family members
Autor: L A Timmerman, J I Healy, S N Ho, L Chen, C C Goodnow, G R Crabtree
Publikováno v: The Journal of Immunology. 159:2735-2740
Nuclear factor of activated T cells (NF-AT) complexes regulate the induction of many early T cell activation molecules. Four related proteins can function as the cytoplasmic subunit of NF-AT, and their overlapping expression patterns and the mild phe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::720f6366b0bc4fc2c79f3c79cbd54ba7
https://doi.org/10.4049/jimmunol.159.6.2735
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4
Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha
Autor: R B, Rose, J H, Bayle, J A, Endrizzi, J D, Cronk, G R, Crabtree, T, Alber
Publikováno v: Nature structural biology. 7(9)
Maturity-onset diabetes of the young type 3 (MODY3) results from mutations in the transcriptional activator hepatocyte nuclear factor-1alpha (HNF-1alpha). Several MODY3 mutations target the HNF-1alpha dimerization domain (HNF-p1), which binds the coa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cba460504c7e6cfa837acf8362d17201
https://pubmed.ncbi.nlm.nih.gov/10966642
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7
Purification and biochemical heterogeneity of the mammalian SWI-SNF complex
Autor: W, Wang, J, Côté, Y, Xue, S, Zhou, P A, Khavari, S R, Biggar, C, Muchardt, G V, Kalpana, S P, Goff, M, Yaniv, J L, Workman, G R, Crabtree
Publikováno v: The EMBO journal. 15(19)
We have purified distinct complexes of nine to 12 proteins [referred to as BRG1-associated factors (BAFs)] from several mammalian cell lines using an antibody to the SWI2-SNF2 homolog BRG1. Microsequencing revealed that the 47 kDa BAF is identical to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f3c6b90c405e2ba207ffa02f697ea181
https://pubmed.ncbi.nlm.nih.gov/8895581
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9
Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin
Autor: J, Nourse, E, Firpo, W M, Flanagan, S, Coats, K, Polyak, M H, Lee, J, Massague, G R, Crabtree, J M, Roberts
Publikováno v: Nature. 372(6506)
The cyclin-dependent kinase (Cdk) enzymes, when associated with the G1 cyclins D and E, are rate-limiting for entry into the S phase of the cell cycle. During T-cell mitogenesis, antigen-receptor signalling promotes synthesis of cyclin E and its cata
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::81f27d1f42019194f26bdc8f5c43ccf5
https://pubmed.ncbi.nlm.nih.gov/7990932
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10
Molecular analysis of the interaction of calcineurin with drug-immunophilin complexes
Autor: N A, Clipstone, D F, Fiorentino, G R, Crabtree
Publikováno v: The Journal of biological chemistry. 269(42)
The calcium/calmodulin-regulated phosphatase calcineurin (CN) is the site of action of the immunosuppressive drugs cyclosporin A (CsA) and FK506. CN has recently been established as a key signaling enzyme in the T cell signal transduction cascade and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f5527fc48cffa493d43376f1dd071b66
https://pubmed.ncbi.nlm.nih.gov/7523407
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