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Anti-endotoxin activity of a novel synthetic lipid A analog

Autor: T, Kawata, J R, Bristol, J R, Rose, D P, Rossignol, W J, Christ, O, Asano, G R, Dubuc, W E, Gavin, L D, Hawkins, Y, Kishi

Publikováno v: Progress in clinical and biological research. 392

Lipid As from non-toxic bacteria such as Rhodobacter capsulatus and Rhodobacter sphaeroides have been shown to antagonize the immunostimulatory effects of lipid A and LPS from pathogenic bacteria. We have biologically characterized a series of synthe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::53d7c4abd31729a7d7272fb26eb61010
https://pubmed.ncbi.nlm.nih.gov/8524958

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Akademický článek

Nonreducing Sugar Scaffold Enables the Development of Immunomodulatory TLR4-specific LPS Mimetics with Picomolar Potency.

Autor: Strobl S; Department of Chemistry, BOKU University, Muthgasse 18, Vienna, A-1190, Austria., Zucchetta D; Department of Chemistry, BOKU University, Muthgasse 18, Vienna, A-1190, Austria., Vašíček T; Department of Chemistry, BOKU University, Muthgasse 18, Vienna, A-1190, Austria., Monti A; Department of Chemistry, BOKU University, Muthgasse 18, Vienna, A-1190, Austria., Ruda A; Department of Organic Chemistry, Stockholm University, S-106 91, Stockholm, Sweden., Widmalm G; Department of Organic Chemistry, Stockholm University, S-106 91, Stockholm, Sweden., Heine H; Research Group Innate Immunity, Research Center Borstel, Leibniz Lung Center, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Parkallee 22, Borstel, 23845, Germany., Zamyatina A; Department of Chemistry, BOKU University, Muthgasse 18, Vienna, A-1190, Austria.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Sep 23; Vol. 63 (39), pp. e202408421. Date of Electronic Publication: 2024 Aug 21.

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Akademický článek

Structure-Based Design and Synthesis of Lipid A Derivatives to Modulate Cytokine Responses.

Autor: Verpalen ECJM; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG, Utrecht, The Netherlands., Brouwer AJ; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG, Utrecht, The Netherlands., Wolfert MA; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG, Utrecht, The Netherlands.; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA., Boons GJ; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG, Utrecht, The Netherlands.; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.; Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands.; Chemistry Department, University of Georgia, Athens, GA 30602, USA.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Jun 06; Vol. 30 (32), pp. e202400429. Date of Electronic Publication: 2024 May 06.

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