Zobrazeno 1 - 10
of 17
pro vyhledávání: '"G R, Bicknell"'
Publikováno v:
Transplant International. 17:9-14
Modern immunosuppressive agents such as tacrolimus and rapamycin are claimed to be associated with a reduction in vascular narrowing, a central feature of chronic rejection. This study assesses the effect of cyclosporine, tacrolimus and rapamycin on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c33e6db0d95bfa198f72f9309ba462
https://doi.org/10.1007/s00147-003-0653-8
https://doi.org/10.1007/s00147-003-0653-8
Publikováno v:
Transplantation. 75:772-780
BACKGROUND Overexposure to cyclosporine is a risk factor for chronic allograft nephropathy (CAN) and dose reduction has been advocated. The purpose of this study was to determine the impact of adding the non-nephrotoxic immunosuppressant, rapamycin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc1fe08ced9fd63be7a2a9105ecb362
https://doi.org/10.1097/00007890-200303270-00008
https://doi.org/10.1097/00007890-200303270-00008
Publikováno v:
British Journal of Surgery. 89:1055-1061
BackgroundChronic allograft dysfunction (CAD), the leading cause of solid organ transplant failure, is characterized by histological evidence of extracellular matrix (ECM) accumulation (fibrosis). The aim of this study was to characterize the changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded1229f1cb4426482fa4895f98c2850
https://doi.org/10.1046/j.1365-2168.2002.02180.x
https://doi.org/10.1046/j.1365-2168.2002.02180.x
Publikováno v:
British Journal of Surgery. 87:1563-1568
Background Cyclosporin is associated with significant chronic nephrotoxicity, manifest in the long term mainly as renal fibrosis. There have been claims that tacrolimus is a less fibrotic drug than cyclosporin, and this study was designed to determin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf05d31a23520c256648efcba5ec98e4
https://doi.org/10.1046/j.1365-2168.2000.01576.x
https://doi.org/10.1046/j.1365-2168.2000.01576.x
Autor:
Peter N. Furness, L L Hall, G Barker, Mark E. Thomas, G. R. Bicknell, S M Jalalah, J.H. Pringle, Jacqui Shaw
Publikováno v:
The Journal of Pathology. 191:61-66
Remodelling of the extracellular matrix requires tight control not only of matrix synthesis, but also of matrix degradation. Control of matrix degradation is achieved mainly through the matrix metalloproteinase (MMP) enzymes. In the glomerulus, MMP-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5277d19f4dd78bc6a83138dd5e1d131
https://doi.org/10.1002/(sici)1096-9896(200005)191:1<61::aid-path565>3.0.co
https://doi.org/10.1002/(sici)1096-9896(200005)191:1<61::aid-path565>3.0.co
Publikováno v:
British Journal of Surgery. 86:1144-1148
Background Experimental evidence suggests that transforming growth factor (TGF) β1 is a fibrogenic cytokine. The histopathological changes of chronic renal allograft nephropathy are dominated by fibrotic changes and TGF-β may have an important aeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8319f7434f3246990858dc2c29eaacf4
https://doi.org/10.1046/j.1365-2168.1999.01202.x
https://doi.org/10.1046/j.1365-2168.1999.01202.x
Publikováno v:
Transplantation Proceedings. 34:2881-2883
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e254ff031b1bc3455f662af238676cf5
https://doi.org/10.1016/s0041-1345(02)03545-5
https://doi.org/10.1016/s0041-1345(02)03545-5
Publikováno v:
The British journal of surgery. 90(8)
Background Acute allograft rejection is thought to be a risk factor for chronic allograft nephropathy, the cardinal features of which are vasculopathy, interstitial fibrosis and glomerulosclerosis. Fibrosis-associated genes might act as ad interim su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd6f15e4a9676f31dd9496120ceb7b0
https://pubmed.ncbi.nlm.nih.gov/12905557
https://pubmed.ncbi.nlm.nih.gov/12905557
Publikováno v:
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 22(5)
Background: Rapamycin inhibits extracellular matrix (ECM) accumulation (fibrosis) and vascular remodeling in experimental models of chronic allograft dysfunction (CAD) by poorly understood mechanisms. The aim of this study was to assess the effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42496db1c28ea5a94f093a723bae7ac
https://pubmed.ncbi.nlm.nih.gov/12742415
https://pubmed.ncbi.nlm.nih.gov/12742415
Publikováno v:
The British journal of surgery. 89(7)
Background Chronic renal allograft nephropathy is characterized by an abnormal accumulation of extracellular matrix proteins in the glomeruli and tubulo-interstitium. The aim of this study was to determine the relationship between intragraft expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0fcab964f895ee2bc726ecd887b669
https://pubmed.ncbi.nlm.nih.gov/12081746
https://pubmed.ncbi.nlm.nih.gov/12081746