Zobrazeno 1 - 10
of 28
pro vyhledávání: '"G Praveen Raju"'
Autor:
Naomi Mayman, Jiangbo Wei, Shangjun Cai, Rohan Soman, Hillary Raynes, Maite La Vega-Talbott, Chuan He, Thomas Naidich, G. Praveen Raju, Sathiji Kathiresu Nageshwaran
Publikováno v:
SAGE Open Medical Case Reports, Vol 11 (2023)
The fat mass and obesity-associated gene ( FTO ) codes for a DNA/RNA demethylase. Pathological variants in this gene are rare, with only three reports in the literature, all with mutations in the catalytic domain. We report the first biallelic human
Externí odkaz:
https://doaj.org/article/f75930d2cefe4b9a8cd20f0a011b5c90
Autor:
Swati Dhar, Samantha Gadd, Priyam Patel, Jake Vaynshteyn, G. Praveen Raju, Rintaro Hashizume, Daniel J. Brat, Oren J. Becher
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-14 (2022)
Abstract Pediatric high-grade gliomas, specifically diffuse midline gliomas, account for only 20% of clinical cases but are 100% fatal. A majority of the DMG cases are characterized by the signature K27M mutation in histone H3. The H3K27M mutation op
Externí odkaz:
https://doaj.org/article/39dc7b63531246f9bc018c91bf8bc1de
Autor:
Daniel E. Tylawsky, Hiroto Kiguchi, Jake Vaynshteyn, Jeffrey Gerwin, Janki Shah, Taseen Islam, Jacob A. Boyer, Daniel R. Boué, Matija Snuderl, Matthew B. Greenblatt, Yosi Shamay, G. Praveen Raju, Daniel A. Heller
Publikováno v:
Nature Materials. 22:391-399
Medulloblastoma is the most common malignant paediatric brain tumour, with ~30% mediated by Sonic hedgehog signalling. Vismodegib-mediated inhibition of the Sonic hedgehog effector Smoothened inhibits tumour growth but causes growth plate fusion at e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc1d70af9c05cc7c2ec3b92c55ca03fc
https://doi.org/10.1038/s41563-023-01481-9
https://doi.org/10.1038/s41563-023-01481-9
Autor:
Giselle A. Suero-Abreu, G. Praveen Raju, Orlando Aristizábal, Eugenia Volkova, Alexandre Wojcinski, Edward J. Houston, Diane Pham, Kamila U. Szulc, Daniel Colon, Alexandra L. Joyner, Daniel H. Turnbull
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 12, Pp 993-1006 (2014)
Mouse models have increased our understanding of the pathogenesis of medulloblastoma (MB), the most common malignant pediatric brain tumor that often forms in the cerebellum. A major goal of ongoing research is to better understand the early stages o
Externí odkaz:
https://doaj.org/article/cc285388a4fa421f9987def3ca0812f4
Autor:
Ross Keller, Makiko Yamada, Daniel Cameron, Hiromichi Suzuki, Reeti Sanghrajka, Jake Vaynshteyn, Jeffrey Gerwin, Francesco Maura, William Hooper, Minita Shah, Nicolas Robine, Philip Demarest, N. Sumru Bayin, Luz Jubierre, Casie Reed, Michael D. Taylor, Alexandra L. Joyner, G. Praveen Raju, Alex Kentsis
Genomic rearrangements are a hallmark of most solid tumors, including medulloblastoma, one of the most common brain tumors in children. Childhood cancers involve dysregulated cell development, but their mutational causes remain largely unknown. One o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5f402393cd72cef69bf54a7c55ad609
https://doi.org/10.1101/2022.07.05.498128
https://doi.org/10.1101/2022.07.05.498128
Publikováno v:
Cancer Research. 83:1992-1992
Medulloblastoma (MB) is the most common malignant pediatric brain tumor with ~30% mediated by Sonic hedgehog (SHH) signaling. While SHH effector Smoothened inhibition is promising, therapeutic index is reduced by high systemic doses required for suff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3648fa4686a397f336806d3c92813b8a
https://doi.org/10.1158/1538-7445.am2023-1992
https://doi.org/10.1158/1538-7445.am2023-1992
Publikováno v:
Cell Reports, Vol 2, Iss 2, Pp 386-396 (2012)
Mosaic mutant analysis, the study of cellular defects in scattered mutant cells in a wild-type environment, is a powerful approach for identifying critical functions of genes and has been applied extensively to invertebrate model organisms. A highly
Externí odkaz:
https://doaj.org/article/076be41292ae45c5b51d94bba4d0dac7
Autor:
Swati Dhar, Samantha Gadd, Priyam Patel, Jake Vaynshteyn, G. Praveen Raju, Rintaro Hashizume, Daniel J. Brat, Oren J. Becher
Publikováno v:
Acta neuropathologica communications. 10(1)
Pediatric high-grade gliomas, specifically diffuse midline gliomas, account for only 20% of clinical cases but are 100% fatal. A majority of the DMG cases are characterized by the signature K27M mutation in histone H3. The H3K27M mutation opposes the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8bc5a2f00112b803b28e1b54875642
https://pubmed.ncbi.nlm.nih.gov/35395831
https://pubmed.ncbi.nlm.nih.gov/35395831
Autor:
Ivy Tran, Kristyn Galbraith, Guisheng Zhao, Robyn Borsuk, Joyce Varkey, Sharon Gardner, Jeffrey Allen, David Harter, Jeffrey Wisoff, Eveline T. Hidalgo, Sunil Deochand, Dillon Maloney, Danielle Afterman, Tomer Lauterman, Noah Friedman, Imane Bourzgui, Nidhi Ramaraj, Zohar Donenhirsh, Ronel Veksler, Jonathan Rosenfeld, Ravi Kandasamy, Iman Tavassoly, Boris Oklander, G. Praveen Raju, Theodore Nicolaides, Asaf Zviran, Matija Snuderl
Publikováno v:
Cancer Research. 82:3401-3401
Introduction: Liquid biopsy offers a noninvasive approach to monitor cancer burden during therapy and surveillance period. However, in pediatric brain cancers, liquid biopsy methods from the blood have been unsuccessful due to a low tumor burden and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b08d42f08fd0b0d3601bedfc2b67ecdd
https://doi.org/10.1158/1538-7445.am2022-3401
https://doi.org/10.1158/1538-7445.am2022-3401
Autor:
Hiroto Kiguchi, Mandana Manzari, Jake Vaynshteyn, Jeffrey Gerwin, Daniel Tylawsky, Na Li, Janki Shah, Yosi Shamay, Matthew Greenblatt, Daniel Heller, G Praveen Raju
Publikováno v:
Neuro Oncol
OBJECTIVE The Sonic Hedgehog (SHH) medulloblastoma subgroup accounts for ~25% of all cases and has an intermediate prognosis. Current conventional therapies result in devastating morbidities including intellectual disability and secondary malignancie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c875c5984b4aa4bca157751c857ed738
https://europepmc.org/articles/PMC6846632/
https://europepmc.org/articles/PMC6846632/