Zobrazeno 1 - 10 of 424 pro vyhledávání: '"G Popják"'
1
Akademický článek
A deficiency of mixed function oxidase activities in the cholesterol biosynthetic pathway of human granulocytes.
Autor: I Shechter, A M Fogelman, G Popják
Publikováno v: Journal of Lipid Research, Vol 21, Iss 3, Pp 277-283 (1980)
Highly purified human granulocytes synthesize [14C]farnesol and [14C]squalene but not [14C]sterols from [14C]mevalonic acid. Dimethylsulfoxide was found to be an excellent vehicle for carrying [3H]squalene-2, 3-oxide into the intact cells. The granul
Externí odkaz: https://doaj.org/article/f9cd7ac8761640848c395b6527155ddd
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2
Akademický článek
Determination of mevalonate in blood plasma in man and rat. Mevalonate 'tolerance' tests in man.
Autor: G Popják, G Boehm, T S Parker, J Edmond, P A Edwards, A M Fogelman
Publikováno v: Journal of Lipid Research, Vol 20, Iss 6, Pp 716-728 (1979)
A method is described for the determination of mevalonate in ultrafiltrates of blood plasma. The method depends on the phosphorylation of mevalonate with [gamma-32P]ATP and mevalonate kinase to 5-[32P]phosphomevalonate, and the subsequent isolation o
Externí odkaz: https://doaj.org/article/fec322a682a04880bffa36134ba4db21
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3
Akademický článek
Inhibition of liver prenyltransferase by citronellyl and geranyl phosphonate and phosphonylphosphate.
Autor: G Popják, C Hadley
Publikováno v: Journal of Lipid Research, Vol 26, Iss 9, Pp 1151-1159 (1985)
Citronellyl- and geranylphosphonic acids and the corresponding phosphonylphosphates were made and tested as inhibitors of liver prenyltransferase. Kinetic analysis showed that citronellyl- and geranylphosphonylphosphate were powerful inhibitors of th
Externí odkaz: https://doaj.org/article/3e2ab4fc4e964225922c5afe2d2cea00
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4
Akademický článek
Role of mevalonate in regulation of cholesterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A reductase in cultured cells and their cytoplasts.
Autor: G Popják, C F Clarke, C Hadley, A Meenan
Publikováno v: Journal of Lipid Research, Vol 26, Iss 7, Pp 831-841 (1985)
H4-II-E-C3 hepatoma cells in culture respond to lipid-depleted media and to mevinolin with increased sterol synthesis from [14C]acetate and rise of 3-hydroxy-3-methylglutaryl coenzyme A reductase levels. Mevalonate at 4 mM concentration represses ste
Externí odkaz: https://doaj.org/article/f5561f0de71147e5b87d229cb91fb4d4
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7
In vitro identification of a soluble protein:geranylgeranyl transferase from rat tissues
Autor: G Popják, Alison Joly, Peter A. Edwards
Publikováno v: Journal of Biological Chemistry. 266:13495-13498
The gamma subunit of mammalian trimeric G proteins has been shown previously to be modified in vivo on a cysteine residue situated at the carboxyl-terminal sequence-Cys-Ala-Ile-Leu-COOH by a 20-carbon prenyl moiety geranylgeranyl (Mumby, S. M., Casey
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cf7b094983f68823dcaa9cd25b5bc16
https://doi.org/10.1016/s0021-9258(18)92724-9
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