Výsledky vyhledávání - "G Perez-Manga"

Phase II study of capecitabine in combination with paclitaxel in patients with anthracycline-pretreated advanced/metastatic breast cancer

Autor: F Carabantes, A Murias, Manuel Constenla, P Regueiro, G Perez-Manga, M Söderberg, J Castellanos, Anna Ruiz, Kenneth Villman, M. González Barón, J Casinello, N Batista, J Ahlgren

Publikováno v: British Journal of Cancer

The addition of oral capecitabine to docetaxel improves response rate, time to progression (TTP) and overall survival in anthracycline-pretreated metastatic breast cancer (MBC). This phase II study evaluates the efficacy and safety of a 21-day cycle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277ca994200ed5ee34c0c1a19b3f1514
https://doi.org/10.1038/sj.bjc.6601784

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Role of interferon alfa-2b in the induction and maintenance treatment of low-grade non-Hodgkin's lymphoma: results from a prospective, multicenter trial with double randomization

Autor: Pilar García-Alfonso, José García-Laraña, Consolación Rayón, Manuel González Barón, Ramon Maria Perez Carrion, Esperanza Lavilla, M. Lozano, Pilar Zamora, G. Pérez, José María Fernández-Rañada, G Perez-Manga, Ramon Colomer, J. López, P Sobrino, E. Flores, Arranz R

Publikováno v: Journal of Clinical Oncology. 16:1538-1546

PURPOSE To evaluate the effectiveness of adding interferon (IFN) alfa-2b to chemotherapy in the induction treatment of low-grade non-Hodgkin's lymphoma (NHL), and to assess the role of maintenance IFN. PATIENTS AND METHODS A multicenter, two-phase co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bda791229cd36ae6da8387904479dfb
https://doi.org/10.1200/jco.1998.16.4.1538

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‘Tomudex’ (ZD1694): Results of a Randomised Trial in Advanced Colorectal Cancer Demonstrate Efficacy and Reduced Mucositis and Leucopenia

Autor: K. Lowery, David Cunningham, M. Azab, J.F. Seitz, U. Rath, G. Perez-Manga, E. Van Cutsem, C. Svensson, Ian N. Olver, John Zalcberg, David J. Kerr, Leonard W. Seymour, Peter Harper

Publikováno v: European Journal of Cancer. 32:1945-1954

'Tomudex' (ZD1694), a direct and specific thymidylate synthase (TS) inhibitor entered phase III studies in November 1993. We present here the first analysis of a randomised multicentre, international phase III study. 439 patients with previously untr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fada5b93c4ca1cf4aa809ae252c7578
https://doi.org/10.1016/0959-8049(96)88251-7

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Diffuse large B-cell lymphoma in the older

Autor: F. Mestre, Antonio Gutierrez, G. Perez-Manga, J. Rodríguez

Publikováno v: Critical reviews in oncology/hematology. 78(1)

The incidence of diffuse large B-cell lymphoma (DLCL) in the older is growing to the point of becoming a health priority in the next decades. Prognostic factors and the biology of the tumor are not very different between younger and older populations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3eb735550103a061ef82506e157d063
https://pubmed.ncbi.nlm.nih.gov/20303778

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Current and future aggressive peripheral T-cell lymphoma treatment paradigms, biological features and therapeutic molecular targets

Autor: G. Perez-Manga, Antonio Gutierrez, B. Martínez-Delgado, J. Rodríguez

Publikováno v: Critical reviews in oncology/hematology. 71(3)

Prognosis of PTCL is generally poor when treated with conventional chemotherapy regimens used in B-cell aggressive lymphomas. Recent advances in genomic and molecular profiling of PTCL have allowed to further insight this heterogeneous group of neopl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de10b8856e7e6febf7c4b6298f2de511
https://pubmed.ncbi.nlm.nih.gov/19056295

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Improved incidence of pT0 downstaged surgical specimens in locally advanced rectal cancer (LARC) treated with induction oxaliplatin plus 5-fluorouracil and preoperative chemoradiation

Autor: D. De la Mata, E. Alvarez, Felipe A. Calvo, E. Lozano, M. Gomez-Espi, F. J. Serrano, R. Garcia, J.A. Diaz-Gonzalez, Pilar García-Alfonso, J.A. Arranz, G. Perez-Manga

Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology. 17(7)

PURPOSE To compare efficacy in terms of pathologic response in LARC patients treated with preoperative chemoradiation, with or without a short-intense course of induction oxaliplatin. PATIENTS AND METHODS From 05/98 to 10/02, 114 patients were treate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d719c41e2c7822f9c290b7ba9216197f
https://pubmed.ncbi.nlm.nih.gov/16670204

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Oral capecitabine vs intravenous 5-fluorouracil and leucovorin: integrated efficacy data and novel analyses from two large, randomised, phase III trials

Autor: Wolff Schmiegel, Paulo M. Hoff, J Lokich, Edith P. Mitchell, P Dufour, J. Schoelmerich, David Cunningham, Ullrich Graeven, G. Perez-Manga, Alberto Sobrero, R M Bukowski, S Madajewicz, Richard L. Schilsky, Peter Harper, Jean A. Maroun, E. Van Cutsem, John L. Marshall, Ph. Rougier

Publikováno v: British Journal of Cancer

This study evaluates the efficacy of capecitabine using data from a large, well-characterised population of patients with metastatic colorectal cancer (mCRC) treated in two identically designed phase III studies. A total of 1207 patients with previou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ad4677e1ec4f0ac9d0aaf4c9d00098
http://hdl.handle.net/11390/851180

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First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin

Autor: Paulo M. Hoff, U. Burger, Ullrich Graeven, Richard L. Schilsky, Riccardo Rosso, Ph. Rougier, John Marshall, Osterwalder B, G. Perez-Manga, Michael Boyer, Jim Cassidy, Joseph McKendrick, E. Van Cutsem, Roland Bugat, A. Garin, Jean A. Maroun, Chris Twelves, Emilio Bajetta

Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology. 13(4)

Purpose To evaluate the safety profile of capecitabine using data from a large, well-characterized population of patients with metastatic colorectal cancer treated in two phase III studies. In these trials, capecitabine achieved significantly superio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5550ffdf0de1324d7c8899afdeea5b5
https://pubmed.ncbi.nlm.nih.gov/12056707

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Phase II trial of raltitrexed ('Tomudex') in advanced small-cell lung cancer

Autor: T. Le Chevalier, Nick Thatcher, Peter Drings, Penella J. Woll, A Adenis, R Basser, Frederick P. Smith, L. Seymour, G Perez Manga

Publikováno v: Europe PubMed Central
British Journal of Cancer

Raltitrexed, a thymidylate synthase inhibitor, was given to 21 patients with advanced small-cell lung cancer, at a dose of 3 mg m(-2) as a 15-min intravenous infusion at 21-day intervals. All of the patients had extensive disease and 17 had received

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915ac4c689c03ddfae118aca29f9c863

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