Zobrazeno 1 - 10
of 773
pro vyhledávání: '"G Pakhomov"'
Publikováno v:
Cell Stress, Vol 8, Pp 69-82 (2024)
Exceeding physiological limits of the cell membrane potential compromises structural integrity, enabling the passage of normally impermeant solutes and disrupting cell function. Electropermeabilization has been studied extensively at the cellular sca
Externí odkaz:
https://doaj.org/article/55b6e8adaf35419c9ed03a5de82da14e
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Ablation therapies aim at eradication of tumors with minimal impact on surrounding healthy tissues. Conventional pulsed electric field (PEF) treatments cause pain and muscle contractions far beyond the ablation area. The ongoing quest is to
Externí odkaz:
https://doaj.org/article/e1a7318d9abb4d3d85666cbb65639cd6
Autor:
Pamela W. Sowa, Aleksander S. Kiełbik, Andrei G. Pakhomov, Emily Gudvangen, Uma Mangalanathan, Volker Adams, Olga N. Pakhomova
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Electric shocks, the only effective therapy for ventricular fibrillation, also electroporate cardiac cells and contribute to the high-mortality post-cardiac arrest syndrome. Copolymers such as Poloxamer 188 (P188) are known to preserve the membrane i
Externí odkaz:
https://doaj.org/article/358634790a3b4390b8c7673860881b99
Autor:
Vitalii Kim, Iurii Semenov, Allen S. Kiester, Mark A. Keppler, Bennett L. Ibey, Joel N. Bixler, Ruben M. L. Colunga Biancatelli, Andrei G. Pakhomov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10921 (2023)
Reversing the pulse polarity, i.e., changing the electric field direction by 180°, inhibits electroporation and electrostimulation by nanosecond electric pulses (nsEPs). This feature, known as “bipolar cancellation,” enables selective remote tar
Externí odkaz:
https://doaj.org/article/9fdf99ff78644d5aa3bb432c3ae2016b
Autor:
Giedre Silkuniene, Uma M. Mangalanathan, Alessandra Rossi, Peter A. Mollica, Andrei G. Pakhomov, Olga Pakhomova
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9191 (2023)
The study was aimed at identifying endogenous proteins which assist or impede the permeabilized state in the cell membrane disrupted by nsEP (20 or 40 pulses, 300 ns width, 7 kV/cm). We employed a LentiArray CRISPR library to generate knockouts (KOs)
Externí odkaz:
https://doaj.org/article/e8d6fc7665854ee3a58c33bde6a50352
Autor:
Emily Gudvangen, Uma Mangalanathan, Iurii Semenov, Allen S. Kiester, Mark A. Keppler, Bennett L. Ibey, Joel N. Bixler, Andrei G. Pakhomov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2854 (2023)
Cancer ablation therapies aim to be efficient while minimizing damage to healthy tissues. Nanosecond pulsed electric field (nsPEF) is a promising ablation modality because of its selectivity against certain cell types and reduced neuromuscular effect
Externí odkaz:
https://doaj.org/article/2cb49b584fa24bf1b6d26c216e9e8c31
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257287 (2021)
AimsRecently, a new defibrillation modality using nanosecond pulses was shown to be effective at much lower energies than conventional 10 millisecond monophasic shocks in ex vivo experiments. Here we compare the safety factors of 300 nanosecond and 1
Externí odkaz:
https://doaj.org/article/02ce03bdcbf84b6fb033460c92a17184
Publikováno v:
Applied Sciences, Vol 11, Iss 24, p 11782 (2021)
Pulsed electric fields in the sub-microsecond range are being increasingly used in biomedical and biotechnology applications, where the demand for high-voltage and high-frequency pulse generators with enhanced performance and pulse flexibility is pus
Externí odkaz:
https://doaj.org/article/c28592cdf3d043cbbc73f86385cae2e1
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 7051 (2021)
Intense pulsed electric fields (PEF) are a novel modality for the efficient and targeted ablation of tumors by electroporation. The major adverse side effects of PEF therapies are strong involuntary muscle contractions and pain. Nanosecond-range PEF
Externí odkaz:
https://doaj.org/article/3768f64f89c449358530ace7bfb8a861
Autor:
Andrei G. Pakhomov, Emily Gudvangen, Uma Mangalanathan, Oleg Kondratiev, Luis Redondo, Iurii Semenov
Publikováno v:
Bioelectrochemistry. 152:108437