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of 10
pro vyhledávání: '"G P, Visentin"'
Autor:
M. L. Guarino, I. Massimi, S. Mardente, A. Lappa, S. Donfrancesco, G. P. Visentin, F. M. Pulcinelli
Publikováno v:
Platelets, Vol 28, Iss 7, Pp 728-730 (2017)
Heparin-induced thrombocytopenia (HIT) is a thrombotic complication of heparin therapy. The most used functional method for HIT diagnosis is serotonin release assay (SRA). A different functional method based on ATP release with luciferin/luciferase l
Externí odkaz:
https://doaj.org/article/06f8b6c6c14d4a3db06eba1b54150cb9
Autor:
Isabella Massimi, Maria Luisa Guarino, A Lappa, S Donfrancesco, Fabio M. Pulcinelli, Stefania Mardente, G P Visentin
Publikováno v:
Platelets. 28(7)
Heparin-induced thrombocytopenia (HIT) is a thrombotic complication of heparin therapy. The most used functional method for HIT diagnosis is serotonin release assay (SRA). A different functional method based on ATP release with luciferin/luciferase l
Publikováno v:
Blood. 77:2668-2676
Recent studies have shown that antibodies characteristic of quinine- and quinidine-induced thrombocytopenia sometimes recognize the platelet membrane glycoprotein (GP) complex IIb/IIIa in addition to their well known target, GPIb/IX. We have investig
Autor:
G P, Visentin
Publikováno v:
Thrombosis and haemostasis. 82(2)
Publikováno v:
Blood. 93(1)
Human PF4 is a heparin-binding chemokine known to be capable of inhibiting endothelial cell proliferation and angiogenesis. To explore the biological mechanisms responsible for this action, we investigated the effect of PF4 on epidermal growth factor
Publikováno v:
Blood. 92(6)
The IIb-IIIa glycoprotein complex is a favored target for allo-, auto-, and drug-dependent antibodies associated with immune thrombocytopenia. A soluble, recombinant form of the GPIIb-IIIa heterodimer that could be produced in large quantities and ma
Publikováno v:
The Journal of biological chemistry. 273(19)
Previous studies have suggested that PECAM-1 mediates cellular interactions via both homophilic and heterophilic adhesive mechanisms. Cell surface glycoaminoglycans have been implicated as one of the heterophilic ligands for PECAM-1. To determine whe
Publikováno v:
American journal of hematology. 54(3)
Recent reports indicate that antibodies associated with heparin-induced thrombocytopenia and thrombosis (HITP) are specific for complexes formed between heparin and the heparin-binding, platelet alpha granule protein, platelet factor 4 (PF4). As with
Publikováno v:
Blood. 85(11)
To assess the potential contribution of the cysteine-rich domain of human platelet glycoprotein (GP) IIIa to the structure of the PlA1 epitope, we used site-directed mutagenesis to substitute alanines for cysteines at key positions potentially involv
Publikováno v:
Blood. 75(12)
The human Baka/Bakb alloantigen system has been implicated in the pathogenesis of post-transfusion purpura and neonatal alloimmune thrombocytopenic purpura. Human alloantisera specific for either the Baka or Bakb allele have been shown to react exclu