Zobrazeno 1 - 3
of 3
pro vyhledávání: '"G P, Pawlowski"'
Autor:
S L, Yates, J G, Phillips, R, Gregory, G P, Pawlowski, L, Fadnis, M A, Khan, S M, Ali, C E, Tedford
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(2)
A new series of 1H-4-substituted imidazole compounds were synthesized and identified as potent and selective histamine (HA) H3 receptor ligands. These ligands establish that HA H3 antagonists exhibit stereoselective and conformational preferences in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::acc76fb1119187d2eae574556061b1c1
https://pubmed.ncbi.nlm.nih.gov/10215699
https://pubmed.ncbi.nlm.nih.gov/10215699
Autor:
C E, Tedford, J G, Phillips, R, Gregory, G P, Pawlowski, L, Fadnis, M A, Khan, S M, Ali, M K, Handley, S L, Yates
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(2)
Previously, a novel series of 1H-4-substituted imidazole compounds were described as potent and selective histamine (HA) H3 receptor ligands (Yates et al., 1999). The present studies extend the structure-activity relationships for optimal HA H3 recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ebef870114dde0cbcd94276ce78c7b64
https://pubmed.ncbi.nlm.nih.gov/10215700
https://pubmed.ncbi.nlm.nih.gov/10215700
Autor:
C E, Tedford, S L, Yates, G P, Pawlowski, J W, Nalwalk, L B, Hough, M A, Khan, J G, Phillips, G J, Durant, R C, Frederickson
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 275(2)
GT-2016, a non-thiourea-containing imidazole, has been developed as a histamine H3 antagonist. In vitro and in vivo studies in rats were conducted to characterize receptor selectivity and autoreceptor functionality for GT-2016. GT-2016 demonstrated h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::777045529743ae4834ede59cca29f7b2
https://pubmed.ncbi.nlm.nih.gov/7473144
https://pubmed.ncbi.nlm.nih.gov/7473144