Zobrazeno 1 - 10
of 21
pro vyhledávání: '"G P, O'Neill"'
Autor:
Dieter Söll, G P O'Neill
Publikováno v:
Journal of Bacteriology. 172:6363-6371
In the cyanobacterium Synechocystis sp. strain PCC 6803 (Synechocystis 6803) delta-aminolevulinic acid (ALA), the sole precursor for the synthesis of the porphyrin rings of heme and chlorophyll, is formed from glutamate activated by acylation to tRNA
Publikováno v:
Journal of Biological Chemistry. 265:4058-4063
The formation of delta-aminolevulinic acid, the first committed precursor in porphyrin biosynthesis, occurs in certain bacteria and in the chloroplasts of plants and algae in a three-step, tRNA-dependent transformation of glutamate. Glutamyl-tRNA red
Autor:
S, Bertrand, G Y, Ng, M G, Purisai, S E, Wolfe, M W, Severidt, D, Nouel, R, Robitaille, M J, Low, G P, O'Neill, K, Metters, J C, Lacaille, B M, Chronwall, S J, Morris
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 298(1)
Gabapentin (Neurontin, Pfizer Global RD) is a novel anticonvulsant, antihyperalgesic, and antinociceptive agent with a poorly understood mechanism of action. In this study, we show that gabapentin (EC50 2 microM) inhibited up to 70 to 80% of the tota
Autor:
G Y, Ng, S, Bertrand, R, Sullivan, N, Ethier, J, Wang, J, Yergey, M, Belley, L, Trimble, K, Bateman, L, Alder, A, Smith, R, McKernan, K, Metters, G P, O'Neill, J C, Lacaille, T E, Hébert
Publikováno v:
Molecular pharmacology. 59(1)
Gamma-aminobutyric acid (GABA) activates two qualitatively different inhibitory mechanisms through ionotropic GABA(A) multisubunit chloride channel receptors and metabotropic GABA(B) G protein-coupled receptors. Evidence suggests that pharmacological
Autor:
R, Sullivan, A, Chateauneuf, N, Coulombe, L F, Kolakowski, M P, Johnson, T E, Hebert, N, Ethier, M, Belley, K, Metters, M, Abramovitz, G P, O'Neill, G Y, Ng
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 293(2)
Direct evidence is lacking to show whether the gamma-aminobutyric acid (GABA)(B) gb1-gb2 heterodimer is the signaling form of the receptor. In this study, we tested whether gb1a or gb2 subunits when coexpressed with truncated receptors or metabotropi
Autor:
C C, Chan, S, Boyce, C, Brideau, S, Charleson, W, Cromlish, D, Ethier, J, Evans, A W, Ford-Hutchinson, M J, Forrest, J Y, Gauthier, R, Gordon, M, Gresser, J, Guay, S, Kargman, B, Kennedy, Y, Leblanc, S, Leger, J, Mancini, G P, O'Neill, M, Ouellet, D, Patrick, M D, Percival, H, Perrier, P, Prasit, I, Rodger
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(2)
The discoveries that cyclooxygenase (COX)-2 is an inducible form of COX involved in inflammation and that COX-1 is the major isoform responsible for the production of prostaglandins (PGs) in the gastrointestinal tract have provided a rationale for th
Autor:
G P, O'Neill, B P, Kennedy, J A, Mancini, S, Kargman, M, Ouellet, J, Yergey, J P, Falgueyret, W A, Cromlish, P, Payette, C C, Chan
Publikováno v:
Agents and actions. Supplements. 46
The main target of non-steroidal anti-inflammatory drugs (NSAIDs) is prostaglandin G/H synthase (PGHS), also known as cyclooxygenase (COX), which exists as two isoforms. In order to evaluate the contributions of PGHS isoforms to physiological and pat
Autor:
G. P. O’neill, B. P. Kennedy, J. A. Mancini, S. Kargman, M. Ouellet, J. Yergey, J.-P. Falgueyret, W. A. Cromlish, P. Payette, C.-C. Chan, S. A. Culp, C. Vincent, C. Boily, M. Abramovitz, J. F. Evans, A. W. Ford-Hutchinson, P. J. Vickers, M. D. Percival
Publikováno v:
Novel Molecular Approaches to Anti-Inflammatory Therapy ISBN: 9783034872782
The main target of non-steroidal anti-inflammatory drugs (NSAIDs) is prostaglandin G/H synthase (PGHS), also known as cyclooxygenase (COX), which exists as two isoforms. In order to evaluate the contributions of PGHS isoforms to physiological and pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08a561faab377b4e0222a8bf132d0d0b
https://doi.org/10.1007/978-3-0348-7276-8_16
https://doi.org/10.1007/978-3-0348-7276-8_16
Autor:
G P, O'Neill, J A, Mancini, S, Kargman, J, Yergey, M Y, Kwan, J P, Falgueyret, M, Abramovitz, B P, Kennedy, M, Ouellet, W, Cromlish
Publikováno v:
Molecular pharmacology. 45(2)
Human prostaglandin G/H synthase (hPGHS)-1 and hPGHS-2, key enzymes in the formation of prostanoids from arachidonic acid, were expressed at high levels in COS-7 cells using a T7 RNA polymerase/vaccinia virus expression system. The open reading frame
Publikováno v:
Molecular pharmacology. 42(6)
To identify regions of 5-lipoxygenase-activating protein (FLAP) important for the function of the protein and the binding of leukotriene biosynthesis inhibitors, we performed a cross-species analysis of FLAP. FLAP from all 10 mammalian species analyz