Zobrazeno 1 - 9
of 9
pro vyhledávání: '"G P, Luyten"'
Autor:
N C, Naus, E, van Drunen, A, de Klein, G P, Luyten, D A, Paridaens, J C, Alers, B R, Ksander, H B, Beverloo, R M, Slater
Publikováno v:
Genes, chromosomescancer. 30(3)
Several nonrandom recurrent chromosomal changes are observed in uveal melanoma. Some of these abnormalities, e.g., loss of chromosome 3, gain of the q arm of chromosome 8, and chromosome 6 abnormalities, are of prognostic value. Cytogenetic analysis
Autor:
N C, Naus, W, Zuidervaart, N, Rayman, R, Slater, E, van Drunen, B, Ksander, G P, Luyten, A, Klein
Publikováno v:
International journal of cancer. 87(1)
Autor:
J P, van der Pol, D J, Blom, M J, Flens, G P, Luyten, I, de Waard-Siebinga, L, Koornneef, R J, Scheper, M J, Jager
Publikováno v:
Investigative ophthalmologyvisual science. 38(12)
Metastatic uveal melanoma is strongly resistant to chemotherapy, and multidrug resistance (MDR) may be involved. To investigate the role of MDR, the presence of the MDR-associated proteins P-glycoprotein (Pgp), MRP, and lung resistance protein (LRP)
Publikováno v:
Investigative ophthalmologyvisual science. 38(9)
Because the expression of human leukocyte antigen (HLA) antigens is important for immunologic recognition of tumor cells, we determined expression of locus-specific HLA class I antigens in uveal melanoma and tested whether the level of HLA expression
Autor:
D J, Blom, C M, Mooy, G P, Luyten, S, Kerkvliet, I, Ouwerkerk, A H, Zwinderman, P I, Schrier, M J, Jager
Publikováno v:
The Journal of pathology. 181(1)
HLA class I is expressed in 75-85 per cent of uveal melanoma and cytoplasmic c-myc expression has been reported in 78 per cent of uveal melanoma. In skin melanoma, an inverse relationship has been observed between HLA class I expression and c-myc. Th
Publikováno v:
Cancer. 78(9)
Uveal melanoma often metastasizes late and preferentially to the liver, in contrast to cutaneous melanoma. The objective of the current study was to evaluate the histopathologic and immunohistochemical changes in primary uveal melanomas and their cor
Publikováno v:
Investigative ophthalmologyvisual science. 37(11)
To evaluate the role of nm23 gene expression in the development of metastases of human uveal melanomas in an animal model.Seven human uveal melanoma cell lines and two murine skin melanoma cell lines were subjected to Northern blot analysis for the d
Autor:
G P, Luyten, N C, Naus, C M, Mooy, A, Hagemeijer, J, Kan-Mitchell, E, Van Drunen, V, Vuzevski, P T, De Jong, T M, Luider
Publikováno v:
International journal of cancer. 66(3)
We report on the establishment and characterization of 2 primary (EOM-3, EOM-29) and 3 metastatic uveal melanoma cell lines (OMM-1, OMM-2, OMM-3) and further cytogenetic characterization of a previously described primary uveal melanoma cell line (OCM
Publikováno v:
Investigative ophthalmologyvisual science. 36(2)
The purpose of this study was to determine the susceptibility of human uveal melanoma cells to in vitro and in vivo natural killer (NK) cell-mediated cytolysis and to determine if NK cells influence metastasis from the eye.Four human uveal melanoma c