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ChemInform Abstract: Thromboxane A2 Receptor Antagonists. Synthesis and Activities of Phenylsulfonamido Derivatives

Autor: G P Dubé, Mais De, W L Kurtz, Joseph A. Jakubowski, K A Brune, Barbara G. Utterback, F. Mohamadi, M. M. Spees

Publikováno v: ChemInform. 23

A number of phenylsulfonamido derivatives have been synthesized and tested for their ability to inhibit: a) thromboxane A 2 /prostaglandin H 2 ( TXA 2 PGH 2 ) mimetic (U46619)- induced guinea pig platelet aggregation; b) aortic ring contraction; and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49ece1fb41c54922e8e00239d2367fec
https://doi.org/10.1002/chin.199211127

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Thromboxane A2 receptor antagonists. Synthesis and activities of phenylsulfonamido derivatives

Autor: G P Dubé, Joseph A. Jakubowski, M. M. Spees, K A Brune, W L Kurtz, Mais De, F. Mohamadi, Barbara G. Utterback

Publikováno v: European Journal of Medicinal Chemistry. 26:821-827

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1f301f45a3bd88accce46d53a325f29
https://doi.org/10.1016/0223-5234(91)90009-c

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Hepatic over-expression of peroxisome proliferator activated receptor gamma2 in the ob/ob mouse model of non-insulin dependent diabetes mellitus

Autor: R, Rahimian, E, Masih-Khan, M, Lo, C, van Breemen, B M, McManus, G P, Dubé

Publikováno v: Molecular and cellular biochemistry. 224(1-2)

Studies of the molecular basis of insulin resistance have focused on the peroxisome proliferator activated receptor gamma (PPARgamma, gamma1 and gamma2). The aim of this study was to determine whether the insulin resistance in liver of diabetic anima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7cf3b5d6fce1ebfe11d4933219dc350a
https://pubmed.ncbi.nlm.nih.gov/11693197

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Inhibition of nitric oxide generation unmasks vascular dysfunction in insulin-resistant, obese JCR:LA-cp rats

Autor: J D, McKendrick, E, Salas, G P, Dubé, J, Murat, J C, Russell, M W, Radomski

Publikováno v: British journal of pharmacology. 124(2)

1. The effects of nitric oxide (NO) on vascular reactivity and platelet function in the obese (cp/cp) and lean (+/?) JCR:LA-cp rats were investigated. 2. Phenylephrine (PE; 0.1 nM-10 microM) induced contraction of isolated aortic rings in both genoty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a4dd3d2aa488de574a772df68dc5b1de
https://pubmed.ncbi.nlm.nih.gov/9641554

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In vivo effects of a novel thromboxane A2/prostaglandin H2 (TXA2/PGH2) partial agonist, (+)5(Z)-7-[3-endo-phenylsulfonylamino[2.2.1]- bicyclohept-2-exo-yl]-heptenoic acid [(+)-S-145], on vascular, platelet and cardiac function

Autor: G P, Dubé, J A, Jakubowski, K A, Brune, K G, Bemis, W L, Kurtz

Publikováno v: The Journal of pharmacology and experimental therapeutics. 272(2)

A novel thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor ligand, (+)5(Z)-7-[3-endo-phenylsulfonylamino[2.2.1]-bicyclohept-2-e xo- yl]-heptenoic acid [(+)-S-145], was evaluated in guinea pigs to assess the in vivo pharmacodynamic profile of this c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88afe9dd16cd1d188d9006eeafbfb08c
https://pubmed.ncbi.nlm.nih.gov/7853197

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In vitro characterization of a novel TXA2/PGH2 receptor ligand (S-145) in platelets and vascular and airway smooth muscle

Autor: G P, Dubé, D E, Mais, J A, Jakubowski, K A, Brune, B G, Utterback, T A, True, L E, Rinkema, W L, Kurtz

Publikováno v: The Journal of pharmacology and experimental therapeutics. 262(2)

The stereoisomers of S-145, a novel thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor ligand, were compared to TXA2/PGH2 receptor antagonists, SQ29548 and BM13505 in guinea pig platelets, aortas and trachea. Equilibrium binding assays in platelets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4c25aca2ddc6af31778defc60720948d
https://pubmed.ncbi.nlm.nih.gov/1386888

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Characterization of a thromboxane A2/prostaglandin H2 receptor in guinea pig lung membranes using a radioiodinated thromboxane mimetic

Autor: D L, Saussy, D E, Mais, G P, Dubé, D E, Magee, K A, Brune, W L, Kurtz, C M, Williams

Publikováno v: Molecular pharmacology. 39(1)

Thromboxane A2 (TXA2) and prostaglandin H2 (PGH2) are potent constrictors of airway smooth muscle and may mediate some of the pulmonary effects of leukotrienes. To date, the TXA2/PGH2 receptor in lung has not been well characterized. In this report,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7beafd082cdab782b42c41f6c1b5cab8
https://pubmed.ncbi.nlm.nih.gov/1824791

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