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Akademický článek

The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells

Autor: D. A. Leach, A. Mohr, E. S. Giotis, E. Cil, A. M. Isac, L. L. Yates, W. S. Barclay, R. M. Zwacka, C. L. Bevan, G. N. Brooke

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

TMPRSS2 is regulated by androgen receptor signalling in the prostate, however it is unclear if blocking this signalling is beneficial in the context of SARS-CoV-2 lung infection. Here the authors show that antiandrogen treatment downregulates TMPRSS2

Externí odkaz: https://doaj.org/article/054d5eddfbac4f51bb25f10d584c7186

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Periodical

TESTIMONIAL TO G. V. BROOKE, TRAGEDIAN, On the Occasion of his Farewell Benefit at the National Theatre, Boston, 27th May, 1853.

Publikováno v: Gleason's Pictorial (Boston, MA - 1853-1854); 06/11/1853, Vol. 4 Issue 102, p380-380, 1p, 1 Illustration

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T-cell responses and the influence of dendritic cells in cattle

Autor: C J, Howard, R A, Collins, P, Sopp, G P, Brooke, L S, Kwong, K R, Parsons, V, Weynants, J J, Letesson, G P, Bembridge

Publikováno v: Advances in veterinary medicine. 41

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2a197a1fd5082d3ba20e719adfc32a7
https://pubmed.ncbi.nlm.nih.gov/9890022

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Cloning of two members of the SIRP alpha family of protein tyrosine phosphatase binding proteins in cattle that are expressed on monocytes and a subpopulation of dendritic cells and which mediate binding to CD4 T cells

Autor: G P, Brooke, K R, Parsons, C J, Howard

Publikováno v: European journal of immunology. 28(1)

Recent experimental studies have greatly clarified the function of cell surface molecules in the induction and modulation of T cell responses by antigen-presenting cells (APC). However, the differences in ability to stimulate T cells evident for diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::28c612eae78ddf44601b8906159b0564
https://pubmed.ncbi.nlm.nih.gov/9485180

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