Zobrazeno 1 - 10
of 41
pro vyhledávání: '"G P, Biro"'
The Intravascular Persistence and Methemoglobin Formation of Hemolink™ (Hemoglobin Raffimer) in Dogs
Publikováno v:
Artificial Cells, Blood Substitutes, and Biotechnology. 31:1-17
Hemoglobin raffimer (HEMOLINK, Hemosol Inc, Mississauga, Canada) is an o-raffinose cross-linked, purified human hemoglobin-based oxygen therapeutic that is currently being evaluated in late stage clinical trials. It is composed of several molecular w
Autor:
G. P. Biro
Publikováno v:
Artificial Cells, Blood Substitutes, and Biotechnology. 28:viii-xii
Publikováno v:
Artificial Cells, Blood Substitutes, and Biotechnology. 24:19-34
Anesthetized mongrel (weight range: 16-27 Kg) dogs were prepared for monitoring hemodynamics, blood flow distribution, plasma colloid osmotic pressure and renal functional parameters at various intervals. Removal of 35 ml/Kg blood resulted in marked
Autor:
G. P. Biro
Publikováno v:
Artificial Cells, Blood Substitutes, and Biotechnology. 22:1343-1353
Mongrel dogs were anesthetized and prepared for hemodynamic monitoring and the measurement of blood flow distribution using radionuclide-labelled microspheres (15 +/- 2 microns). Four dogs were infused with a perflubron emulsion (E) (90% w/v perflubr
Publikováno v:
Critical Reviews in Clinical Laboratory Sciences. 31:295-324
In this review the current status of what commonly are termed "blood substitutes" is discussed. The term blood substitute is a misnomer because the formulations under development at this time transport respiratory gases but do not perform the metabol
Publikováno v:
Biomaterials, Artificial Cells and Immobilization Biotechnology. 20:1013-1020
Unmodified, and to a lesser extent, modified stroma-free hemoglobin preparations have been reported to exhibit coronary and renal vasoconstrictor activity in isolated perfused hearts and kidneys. The physiological significance in vivo of such ex vivo
Autor:
Anne-Marie Gosselin, G. P. Biro
Publikováno v:
Angiology. 41:1058-1064
The effects of low-dose (10-9 and 3x10-9 mole/kg/min) infusions of dopexamine HCl, a new synthetic catecholamine with β2-adrenergic and DA 1-dopaminergic agonostic actions, was tested in anesthetized dogs, with and without acute ligation of the left
Autor:
R. Stewart, M. B. Fargey, M. Bosa, J. G. Kingma, Reena Sandhu, D. Gendron, G. P. Biro, N. D. Hamelin, Y. Trudel
Publikováno v:
Artificial cells, blood substitutes, and immobilization biotechnology. 30(2)
Hemoglobin based oxygen-carrying solutions (HBOCs) as hemoglobin replacement therapeutics are being tested for clinical use. Some of these products are associated with elevations in both systemic and pulmonary vascular resistances but their effect on
Publikováno v:
Advances in experimental medicine and biology. 388
Publikováno v:
Artificial cells, blood substitutes, and immobilization biotechnology. 23(6)
Hypovolemic states are characterized by inadequate tissue perfusion; when this state is reversed, the reintroduction of oxygen is accompanied by the excess generation of oxyradicals and these, in turn, may cause "reperfusion injury" in susceptible ti